Zobrazeno 1 - 10
of 161
pro vyhledávání: '"Akiko Koide"'
Autor:
Jianping Li, Yan Li, Akiko Koide, Huihui Kuang, Victor J. Torres, Shohei Koide, Da-Neng Wang, Nathaniel J. Traaseth
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Efflux pump antiporters confer drug resistance to bacteria by coupling proton import with the expulsion of antibiotics from the cytoplasm. Despite efforts there remains a lack of understanding as to how acid/base chemistry drives drug efflux
Externí odkaz:
https://doaj.org/article/adc805a7d0e7498a80ffffeceecb6f54
Autor:
Yanxiang Meng, Sarah E. Garnish, Katherine A. Davies, Katrina A. Black, Andrew P. Leis, Christopher R. Horne, Joanne M. Hildebrand, Hanadi Hoblos, Cheree Fitzgibbon, Samuel N. Young, Toby Dite, Laura F. Dagley, Aarya Venkat, Natarajan Kannan, Akiko Koide, Shohei Koide, Alisa Glukhova, Peter E. Czabotar, James M. Murphy
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract The necroptosis pathway is a lytic, pro-inflammatory mode of cell death that is widely implicated in human disease, including renal, pulmonary, gut and skin inflammatory pathologies. The precise mechanism of the terminal steps in the pathway
Externí odkaz:
https://doaj.org/article/3125421e28064554a4a1522779b6993c
Autor:
Ellie N. Ivanova, Jasmine Shwetar, Joseph C. Devlin, Terkild B. Buus, Sophie Gray-Gaillard, Akiko Koide, Amber Cornelius, Marie I. Samanovic, Alberto Herrera, Eleni P. Mimitou, Chenzhen Zhang, Trishala Karmacharya, Ludovic Desvignes, Niels Ødum, Peter Smibert, Robert J. Ulrich, Mark J. Mulligan, Shohei Koide, Kelly V. Ruggles, Ramin S. Herati, Sergei B. Koralov
Publikováno v:
iScience, Vol 26, Iss 12, Pp 108572- (2023)
Summary: SARS-CoV-2 infection and vaccination elicit potent immune responses. Our study presents a comprehensive multimodal single-cell analysis of blood from COVID-19 patients and healthy volunteers receiving the SARS-CoV-2 vaccine and booster. We p
Externí odkaz:
https://doaj.org/article/7cfa8f0f1d8949ed9f5a4be014f10380
Autor:
Niklas Ravn-Boess, Nainita Roy, Takamitsu Hattori, Devin Bready, Hayley Donaldson, Christopher Lawson, Cathryn Lapierre, Aryeh Korman, Tori Rodrick, Enze Liu, Joshua D. Frenster, Gabriele Stephan, Jordan Wilcox, Alexis D. Corrado, Julia Cai, Rebecca Ronnen, Shuai Wang, Sara Haddock, Jonathan Sabio Ortiz, Orin Mishkit, Alireza Khodadadi-Jamayran, Aris Tsirigos, David Fenyö, David Zagzag, Julia Drube, Carsten Hoffmann, Fabiana Perna, Drew R. Jones, Richard Possemato, Akiko Koide, Shohei Koide, Christopher Y. Park, Dimitris G. Placantonakis
Publikováno v:
Cell Reports, Vol 42, Iss 11, Pp 113374- (2023)
Summary: Glioblastoma (GBM) is the most common and aggressive primary brain malignancy. Adhesion G protein-coupled receptors (aGPCRs) have attracted interest for their potential as treatment targets. Here, we show that CD97 (ADGRE5) is the most promi
Externí odkaz:
https://doaj.org/article/e954f101e34e4454841a124bf6a6e405
Autor:
Kai Wen Teng, Steven T. Tsai, Takamitsu Hattori, Carmine Fedele, Akiko Koide, Chao Yang, Xuben Hou, Yingkai Zhang, Benjamin G. Neel, John P. O’Bryan, Shohei Koide
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Most oncogenic RAS mutants remain undruggable. Here, the authors developed monobodies that selectively recognize the active state of KRAS(G12V) and KRAS(G12C) and demonstrated their utility in inhibiting RAS functions through inhibition and degradati
Externí odkaz:
https://doaj.org/article/1c4337f6a3694e9b96918c1bb0fcb1f7
Autor:
Sarah E. Garnish, Yanxiang Meng, Akiko Koide, Jarrod J. Sandow, Eric Denbaum, Annette V. Jacobsen, Wayland Yeung, Andre L. Samson, Christopher R. Horne, Cheree Fitzgibbon, Samuel N. Young, Phoebe P. C. Smith, Andrew I. Webb, Emma J. Petrie, Joanne M. Hildebrand, Natarajan Kannan, Peter E. Czabotar, Shohei Koide, James M. Murphy
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Mixed Lineage Kinase Domain-Like (MLKL) pseudokinase is phosphorylated by RIPK3 kinase prior to cell death by necroptosis. Here, the authors use monobodies that bind to the MLKL pseudokinase domain as tools, which allowed them to determine the crysta
Externí odkaz:
https://doaj.org/article/09c7c00c35d347a0a64667b29956b651
Autor:
Maria G. Noval, Maria E. Kaczmarek, Akiko Koide, Bruno A. Rodriguez-Rodriguez, Ping Louie, Takuya Tada, Takamitsu Hattori, Tatyana Panchenko, Larizbeth A. Romero, Kai Wen Teng, Andrew Bazley, Maren de Vries, Marie I. Samanovic, Jeffrey N. Weiser, Ioannis Aifantis, Joan Cangiarella, Mark J. Mulligan, Ludovic Desvignes, Meike Dittmann, Nathaniel R. Landau, Maria Aguero-Rosenfeld, Shohei Koide, Kenneth A. Stapleford
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Understanding antibody responses to SARS-CoV-2 is indispensable for the development of containment measures to overcome the current COVID-19 pandemic. Recent studies showed that serum from convalescent patients can display variable neutraliz
Externí odkaz:
https://doaj.org/article/431b486be8244906b88b8f8c1a505e1f
Autor:
Ali A. Kermani, Christian B. Macdonald, Olive E. Burata, B. Ben Koff, Akiko Koide, Eric Denbaum, Shohei Koide, Randy B. Stockbridge
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Gdx-Clo is a bacterial transporter from the small multidrug resistance (SMR) family. Here, the authors use solid supported membrane electrophysiology to characterize Gdx-Clo functionally and report crystal structures of Gdx-Clo which confirm the dual
Externí odkaz:
https://doaj.org/article/d4785d992fee4f28884dcfc5aaeb641b
Publikováno v:
eLife, Vol 11 (2022)
Proteins from the bacterial small multidrug resistance (SMR) family are proton-coupled exporters of diverse antiseptics and antimicrobials, including polyaromatic cations and quaternary ammonium compounds. The transport mechanism of the Escherichia c
Externí odkaz:
https://doaj.org/article/cc3ac98bd2e3424682e09d21aa8905a9
Autor:
Imran Khan, Akiko Koide, Mariyam Zuberi, Gayatri Ketavarapu, Eric Denbaum, Kai Wen Teng, J. Matthew Rhett, Russell Spencer-Smith, G. Aaron Hobbs, Ernest Ramsay Camp, Shohei Koide, John P. O'Bryan
Publikováno v:
Cell Reports, Vol 38, Iss 6, Pp 110322- (2022)
Summary: RAS guanosine triphosphatases (GTPases) are mutated in nearly 20% of human tumors, making them an attractive therapeutic target. Following our discovery that nucleotide-free RAS (apo RAS) regulates cell signaling, we selectively target this
Externí odkaz:
https://doaj.org/article/c9a4430bc9ea408bb3a1d81302e52240