Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Akiko Koeda"'
Autor:
Takeshi Watanabe, Satoshi Yasuda, Shinji Kusakawa, Takuya Kuroda, Hatsue Furukawa, Mayumi Futamura, Shigekazu Shimizu, Akihiko Morishita, Shinko Hata, Akiko Koeda, Kana Komatsu, Yoji Sato
Publikováno v:
Regenerative Therapy, Vol 26, Iss , Pp 315-323 (2024)
Introduction: MEASURE2 (Multisite Evaluation Study on Analytical Methods for Non-clinical Safety Assessment of HUman-derived REgenerative Medical Products 2) is a Japanese experimental public–private partnership initiative that aims to standardize
Externí odkaz:
https://doaj.org/article/912fe7017d9e4325ae16d6184b69c4af
Publikováno v:
Dose-Response, Vol 22 (2024)
Background We have been conducting a collaborative study on the thresholds of mutagens. In our previous examinations of cell activity and cell proliferation as endpoints, both displayed hormesis. This time, we conducted experiments to determine thres
Externí odkaz:
https://doaj.org/article/750e5054a6864eb0853e15bd1f7970e3
Publikováno v:
Dose-Response, Vol 19 (2021)
Background: We previously showed that hormetic responses can be established in cell activity tests using human and murine adherent cells. This time, we examined whether hormetic responses can be established in cell proliferation tests using suspended
Externí odkaz:
https://doaj.org/article/7ac3b3d5203f40d5bc10ffd7470345e8
Autor:
Shizuyo Sutou, Akiko Koeda, Kana Komatsu, Toshiyuki Shiragiku, Hiroshi Seki, Kohji Yamakage, Takeru Niitsuma, Toshiyuki Kudo, Akihiro Wakata, (The Mammalian Mutagenicity Study Group,
Publikováno v:
Genes and Environment, Vol 40, Iss 1, Pp 1-10 (2018)
Abstract Background According to the linear no-threshold model (LNT), even the smallest amount of radiation is hazardous. Although the LNT is not based on solid data, this hypothesis has been applied to mutagens and carcinogens. As a result, it has b
Externí odkaz:
https://doaj.org/article/afe7725fcfe0405d8bb9958044c6c6a2
Autor:
Katsunori Nakamura, Takahiro Iwao, Akiko Koeda, Yoko Sakai, Anna Nakanishi, Tamihide Matsunaga, Misaki Yamashita, Shota Mizuno
Publikováno v:
Drug Metabolism and Pharmacokinetics. 35:304-312
Herein, we evaluated CYPs and their nuclear receptor mRNA induction by exposure to typical inducers, omeprazole, rifampicin, and phenobarbital in cynomolgus monkey hepatocytes. Six freshly-isolated hepatocytes and 6 cryopreserved hepatocytes from cyn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::171ce4d8c3e3c3e8f026a3737ca00a41
https://doi.org/10.1016/j.dmpk.2020.03.001
https://doi.org/10.1016/j.dmpk.2020.03.001
Publikováno v:
Dose-Response
Dose-Response, Vol 19 (2021)
Dose-Response, Vol 19 (2021)
Background: We previously showed that hormetic responses can be established in cell activity tests using human and murine adherent cells. This time, we examined whether hormetic responses can be established in cell proliferation tests using suspended
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e02fdcc41b1d944a36964865882321b
http://europepmc.org/articles/PMC8246511
http://europepmc.org/articles/PMC8246511
Autor:
Akiko Koeda, Misaki Yamashita, Tamihide Matsunaga, Shota Mizuno, Anna Nakanishi, Katsunori Nakamura, Yoko Sakai, Takahiro Iwao
Publikováno v:
Drug metabolism and pharmacokinetics. 34(4)
In this study, freshly isolated and cryopreserved cynomolgus monkey hepatocytes were seeded on Cell-able® plates with feeder cells to form spheroids and were cultured for 28 days. As a control, hepatocytes were also cultured with or without feeder c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb26f803db7de03f2062809206cc1ea1
https://pubmed.ncbi.nlm.nih.gov/31174977
https://pubmed.ncbi.nlm.nih.gov/31174977
Autor:
Ryosuke Fukuyama, Tadahiro Hashita, Takahiro Iwao, Misaki Yamashita, Takumi Akagawa, Yuriko Kida, Akiko Koeda, Daichi Onozato, Tamihide Matsunaga
Publikováno v:
Stem cells and development. 27(15)
In preclinical studies, the cynomolgus monkey (CM) model is frequently used to predict the pharmacokinetics of drugs in the human small intestine, because of its evolutionary closeness to humans. Intestinal organoids that mimic the intestinal tissue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b04e1007c36acf58ee3726627fc37f70
https://pubmed.ncbi.nlm.nih.gov/29742964
https://pubmed.ncbi.nlm.nih.gov/29742964
Autor:
Akiko Koeda, Shizuo Narimatsu, Shinsaku Naito, Atsuro Miyata, Kei Mayumi, Nobumitsu Hanioka, Kazufumi Masuda
Publikováno v:
Biochemical Pharmacology. 85:1182-1194
The common marmoset is a promising species for evaluating the safety of drug candidates. To further understand the capacity for drug metabolism in marmosets, a cDNA encoding a CYP2B enzyme was cloned from the total RNA fraction of marmoset liver by 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c3ed13b18e35cdc1f5dda411af80128
https://doi.org/10.1016/j.bcp.2013.01.024
https://doi.org/10.1016/j.bcp.2013.01.024
Autor:
Emiko Okada, Akihisa Maeda, Shuichi Hamada, Yohei Miyamoto, Yasuyoshi Ishikawa, Ayami Tadakuma, Masakatsu Natsume, Shizuyo Sutou, Hiroshi Honda, Kazunori Narumi, Tomohiro Sakuma, Akiko Koeda, Izumi Hanahara, Takashi Watanabe, Madoka Nakajima, Yohei Fujiishi, Michiasa Hirayama, Hisakazu Sanada, Keiyu Oshida, Takayoshi Suzuki, Mahoko Kido, Wakako Ohyama, Rina Minamiguchi, Chie Furihata
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 747:164-175
The general aim of the present study is to discriminate between mouse genotoxic and non-genotoxic hepatocarcinogens via selected gene expression patterns in the liver as analyzed by quantitative real-time PCR (qPCR) and statistical analysis. qPCR was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6dd36e0bc2fb631495242cebec60205
https://doi.org/10.1016/j.mrgentox.2012.04.011
https://doi.org/10.1016/j.mrgentox.2012.04.011