Zobrazeno 1 - 10
of 288
pro vyhledávání: '"Akiko Ishii"'
Autor:
Masato Kiyoshi, Makoto Nakakido, Abdur Rafique, Minoru Tada, Michihiko Aoyama, Yosuke Terao, Satoru Nagatoishi, Hiroko Shibata, Teruhiko Ide, Kouhei Tsumoto, Yuji Ito, Akiko Ishii-Watabe
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Antibody–drug conjugates are powerful tools for combatting a wide array of cancers. Drug conjugation to a therapeutic antibody often alters molecular characteristics, such as hydrophobicity and effector function, resulting in quality deter
Externí odkaz:
https://doaj.org/article/a4721243f36f459b99c6c84c9ea72704
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTSevere acute respiratory syndrome coronavirus 2 (SARS-CoV−2) causes coronavirus disease 2019 (COVID−19). Antibodies induced by SARS-CoV−2 infection or vaccination play pivotal roles in the body’s defense against the virus; many monocl
Externí odkaz:
https://doaj.org/article/c8f4f26f466941008a03624ac128fe83
Publikováno v:
BMC Research Notes, Vol 15, Iss 1, Pp 1-5 (2022)
Abstract Objective Sepsis is a lethal condition characterized by systemic inflammation and multiple organ failure; this condition was initially defined as systemic inflammatory response syndrome (SIRS) due to infection. We previously reported that th
Externí odkaz:
https://doaj.org/article/71cd19bae7a54068b9bdfdbefcedcf96
Autor:
Keiko Tanaka, Akira Tamaoka, Akiko Ishii, Kiyotaka Nakamagoe, Shigeru Chiba, Yasuhiro Ogawa, Tomoyuki Miyamoto, Hiroshi Tsuji, Hideaki Ishido, Hana Takahashi, Megumi Isa, Hiroki Kubota, Aya Imanishi, Yuki Omori, Taisuke Ono, Ko Tsutsui, GoEun Han, Hideaki Kondo, Tetsuo Shimizu, Seiji Nishino, Takashi Kanbayashi
Publikováno v:
BMJ Neurology Open, Vol 5, Iss 1 (2023)
Background Neuromyelitis optica spectrum disorder (NMOSD) diagnostic criteria for inflammatory demyelinating central nervous system diseases included symptomatic narcolepsy; however, no relevant case‐control studies exist. We aimed to examine the r
Externí odkaz:
https://doaj.org/article/4355e78576bd497a99128cda31b29b80
Autor:
Ikuru Miura, Kosuke Okada, Akiko Ishii, Eiji Warabi, Takahisa Watahiki, Keii To, Hitoshi Shimano, Shunichi Ariizumi, Junichi Shoda
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Introduction: Obesity is a risk factor for many diseases because it leads to a reduction in skeletal muscle mass and promotes insulin resistance. p62/Sqstm1-knockout mice are a model of metabolic syndrome; show obesity, insulin resistance, and non-al
Externí odkaz:
https://doaj.org/article/3df68411237e4ec8ae7b1dd2f3dfe5d8
Autor:
Risa Okada, Shin-ichiro Fujita, Riku Suzuki, Takuto Hayashi, Hirona Tsubouchi, Chihiro Kato, Shunya Sadaki, Maho Kanai, Sayaka Fuseya, Yuri Inoue, Hyojung Jeon, Michito Hamada, Akihiro Kuno, Akiko Ishii, Akira Tamaoka, Jun Tanihata, Naoki Ito, Dai Shiba, Masaki Shirakawa, Masafumi Muratani, Takashi Kudo, Satoru Takahashi
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Spaceflight causes a decrease in skeletal muscle mass and strength. We set two murine experimental groups in orbit for 35 days aboard the International Space Station, under artificial earth-gravity (artificial 1 g; AG) and microgravity (μg;
Externí odkaz:
https://doaj.org/article/70a0d1618d87416e809859faa1469440
Publikováno v:
Biomedicines, Vol 11, Iss 5, p 1456 (2023)
Biopharmaceuticals have developed rapidly in recent years due to the remarkable progress in gene recombination and cell culture technologies. Since the basic structure of biopharmaceuticals can be designed and modified, it is possible to control the
Externí odkaz:
https://doaj.org/article/cd44e3aebc254991a76d1087e74a0675
rAAV8 and rAAV9-Mediated Long-Term Muscle Transduction with Tacrolimus (FK506) in Non-Human Primates
Autor:
Akiko Ishii, Hironori Okada, Hiromi Hayashita-Kinoh, Jin-Hong Shin, Akira Tamaoka, Takashi Okada, Shin’ichi Takeda
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 18, Iss , Pp 44-49 (2020)
To establish an efficient, safe immunosuppressive regimen of adeno-associated vector (AAV)-mediated gene therapy for Duchenne muscular dystrophy (DMD), we evaluated the effect of tacrolimus (FK506) on skeletal muscle transduction with AAV8 and AAV9 v
Externí odkaz:
https://doaj.org/article/a58c999022b54f3a9aef2884be3963e7
Autor:
Ginto George, Satoshi Ninagawa, Hirokazu Yagi, Jun-ichi Furukawa, Noritaka Hashii, Akiko Ishii-Watabe, Ying Deng, Kazutoshi Matsushita, Tokiro Ishikawa, Yugoviandi P Mamahit, Yuta Maki, Yasuhiro Kajihara, Koichi Kato, Tetsuya Okada, Kazutoshi Mori
Publikováno v:
eLife, Vol 10 (2021)
Sequential mannose trimming of N-glycan, from M9 to M8B and then to oligosaccharides exposing the α1,6-linked mannosyl residue (M7A, M6, and M5), facilitates endoplasmic reticulum-associated degradation of misfolded glycoproteins (gpERAD). We previo
Externí odkaz:
https://doaj.org/article/341ffd41c9234c5d998d7ae1195a462d
Autor:
Masakazu Kakurai, Naoko Okiyama, Tatsuya Ogawa, Maki Fukuzono, Noriko Kubota, Yasuhiro Fujisawa, Tomohide Kajita, Akiko Ishii, Akira Tamaoka, Toshifumi Nomura
Publikováno v:
Journal of Cutaneous Immunology and Allergy, Vol 5, Iss 1, Pp 22-23 (2022)
Externí odkaz:
https://doaj.org/article/3b35e695d25c474e8bf190803fcab238