Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Akiko Hijikata-Okunomiya"'
Autor:
Kiyoshi Ikeda, Yuko Tsuda, Takuya Sueda, Tadamune Otsubo, Akiko Hijikata-Okunomiya, Naoki Teno, Keiko Wanaka, Keigo Gohda
Publikováno v:
Journal of Peptide Science. 18:620-625
Plasmin is best known as the key molecule in the fibrinolytic system, which is critical for clot lysis and can initiate matrix metalloproteinase (MMP) activation cascade. Along with MMP, plasmin is suggested to be involved in physiological processes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f661a8108e737605a2611a1203435bf
https://doi.org/10.1002/psc.2442
https://doi.org/10.1002/psc.2442
Autor:
Shosuke Okamoto, Yoshio Okada, Yuko Tsuda, Utako Okamoto, Mayako Tada, Keiko Wanaka, Akiko Hijikata-Okunomiya
Publikováno v:
Chemical and Pharmaceutical Bulletin. 49:1457-1463
Based on the structure of Tra-Tyr(O-Pic)-octylamide, a portion of the octylamine was replaced with moieties bearing hydrophobic, basic or acidic groups. Replacement of the C-terminal residue with a moiety bearing a hydrophobic group gave the proper a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d09bf4cbcaefcce78c62766c747aa18f
https://doi.org/10.1248/cpb.49.1457
https://doi.org/10.1248/cpb.49.1457
Autor:
Akiko Hijikata-Okunomiya, Yoshio Okada, Mayako Tada, Atsuko Fukumizu, Keiko Wanaka, Yoko Tsuda, Shosuke Okamoto
Publikováno v:
Chemical and Pharmaceutical Bulletin. 47:1141-1144
Pseudo-peptide analogs of trans-4-aminomethylcyclohexanecarbonyl-L-phenylalanyl-4-aminopheny l acetic acid (PKSI-527, plasma kallikrein selective inhibitor), in which an amide bond (peptide bond) has been replaced by a CH2-NH bond, i.e., trans-4-amin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8baf6ee956cc9e513bc78e82ec816023
https://doi.org/10.1248/cpb.47.1141
https://doi.org/10.1248/cpb.47.1141
Autor:
Yoshio Okada, Shosuke Okamoto, Yuko Tsuda, Utako Okamoto, Mayako Tada, Akiko Hijikata-Okunomiya, Keiko Wanaka
Publikováno v:
Biopolymers. 51:41-50
During the course of the development of active center-directed plasmin inhibitors, it was found that N-(trans-4-aminomethylcyclohexanecarbonyl)-lysine-4-methoxycarbonylanilide inhibited plasma kallikrein more potently than other enzymes such as plasm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::283403b09c2bf7ab1ffb8ef538c761c9
https://doi.org/10.1002/(sici)1097-0282(1999)51:1<41::aid-bip5>3.0.co
https://doi.org/10.1002/(sici)1097-0282(1999)51:1<41::aid-bip5>3.0.co
Autor:
Keiko Wanaka, Yuko Tsuda, Akiko Hijikata-Okunomiya, Noburo Horie, Yoshio Okada, Utako Okamoto, Yukiko Nakaya, Shosuke Okamoto, Mayako Tada
Publikováno v:
Biological and Pharmaceutical Bulletin. 21:105-108
We synthesized a new affinity gel (PKSI-Toyopearl) using a selective synthetic inhibitor of plasma kallikrein (PKSI-527) as an affinity ligand, and employed it for the rapid purification of plasma kallikrein from human plasma. Human plasma activated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca84be359cf3be06f322d420c923d2af
https://doi.org/10.1248/bpb.21.105
https://doi.org/10.1248/bpb.21.105
Publikováno v:
Thrombosis Research. 64:559-569
The prothrombin assay method using the synthetic thrombin-inhibitor MD805 was standardized by fixing the concentrations of MD805 and S-2238 through their extinction coefficients (epsilon 333 for MD805 and epsilon 316 for S-2238). The prothrombin assa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51a1fa234fbeb3a31d5cc8eb0d766ed0
https://doi.org/10.1016/s0049-3848(05)80005-2
https://doi.org/10.1016/s0049-3848(05)80005-2
Autor:
Taketoshi Naito, Naoki Teno, Yoshio Okada, Shosuke Okamoto, Keiko Wanaka, Akiko Hijikata-Okunomiya, Utako Okamoto, Yuko Tsuda
Publikováno v:
Chemical and Pharmaceutical Bulletin. 39:2340-2346
Active center-directed inhibitors of plasmin were designed based on the structure of specific substrates of plasmin and then synthesized. Their effects on plasmin were examined and the structure-inhibitory activity relationship was studied. N alpha-t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f28122c8529f9adb5ae2976655690053
https://doi.org/10.1248/cpb.39.2340
https://doi.org/10.1248/cpb.39.2340
Autor:
Shosuke Okamoto, Keiko Wanaka, Akiko Hijikata-Okunomiya, Yoshio Okada, Utako Okamoto, Yuko Tsuda, Taketoshi Naito, Naoki Teno
Publikováno v:
Chemical and Pharmaceutical Bulletin. 39:2930-2936
Specific plasma kallikrein inhibitors were designed and synthesized and their structure-activity relationship was studied. trans-4-Aminomethylcyclohexanecarbonyl (Tra)-lysyl-4-ethoxycarbonylanilide inhibited plasma kallikrein and plasmin with IC50 va
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e6b110deb37c96e965e51ef285b9c78
https://doi.org/10.1248/cpb.39.2930
https://doi.org/10.1248/cpb.39.2930
Publikováno v:
Thrombosis Research. 59:967-977
MD805, a synthetic thrombin-inhibitor, effectively retarded the time-dependent inactivation of thrombin which was generated endogeneously or added exogeneously in human plasma. The kinetical study of the time-dependent inactivation indicated that the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0eb2f308ec5cf5cabd7e0097cb6b9c9
https://doi.org/10.1016/0049-3848(90)90120-2
https://doi.org/10.1016/0049-3848(90)90120-2
Autor:
Keiko Wanaka, Akiko Hijikata-Okunomiya, Taketoshi Naito, Shosuke Okamoto, Yoshio Okada, Miyako Bohgaki
Publikováno v:
Thrombosis Research. 57:889-895
A highly selective inhibitor of plasma-kallikrein (PK), N-(trans-4-aminomethylcyclohexylcarbonyl)-L-phenylalanine 4-carboxymethyl-anilide hydrochloride, was designed and synthesized by the authors' group, called PKSI-527 in our laboratories. (I) PKSI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5a47a9a8c94a3a7981908daaa7e5fb7
https://doi.org/10.1016/0049-3848(90)90155-6
https://doi.org/10.1016/0049-3848(90)90155-6