Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Akiko, Shiina"'
Autor:
Mizuki Takahashi, Kiyoshi Mizukami, Maki Etori, Yoshida Kenichi, Osamu Suzuki, Taiji Goto, Hiroshi Tsuchida, Takeshi Murata, Tomomi Yoshitomi, Toshiharu Yoshino, Takanori Yamazaki, Akiko Shiina, Shigeki Sasaki, Nana Takagi, Hisashi Takahashi, Masato Tomii, Yoshitaka Sogawa, Naoki Nakao, Tsuyoshi Mikkaichi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:893-899
A PDE4B subtype selective inhibitor is expected to have a wider therapeutic window than non-selective PDE4 inhibitors. In this Letter, two series of 7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidine derivatives and 5,5-dioxo-7,8-dihydro-6H-thiopyrano[3,2-d]
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b7d1702fb30401a223a2f67ffb50cd2
https://doi.org/10.1016/j.bmcl.2013.12.076
https://doi.org/10.1016/j.bmcl.2013.12.076
Autor:
Naoki Nakao, Mizuki Takahashi, Yoshitaka Sogawa, Taiji Goto, Osamu Suzuki, Akiko Shiina, Toshiharu Yoshino, Tsuyoshi Mikkaichi, Kazuki Hirahara, Kiyoshi Mizukami, Tomoko Takahashi, Shigeki Sasaki, Masashi Hasegawa
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:3325-3328
2-Phenyl-4-piperidinyl-6,7-dihydrothieno[3,4-d]pyrimidine derivative (2) was found to be a new PDE4 inhibitor with moderate PDE4B activity (IC50=150 nM). A number of derivatives with a variety of 4-amino substituents and fused bicyclic pyrimidines we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::621d0f301cdeffcad03f674ac91164a3
https://doi.org/10.1016/j.bmcl.2013.03.104
https://doi.org/10.1016/j.bmcl.2013.03.104
Autor:
Seiji, Hori, Kazuhiro, Uchino, Takuyuki, Matsumoto, Hiroki, Yamaguchi, Megumi, Takahashi, Satoko, Hamajima, Kaori, Nukui, Hisano, Eda, Akiko, Shiina, Atsushi, Takita, Naoki, Yamanouchi, Masami, Mizuno, Yukihiro, Okutani
Publikováno v:
The Japanese journal of antibiotics. 67(3)
Sitafloxacin (STFX, Gracevit 50 mg, fine granules 10%), an oral quinolone antibacterial agent, was approved additionally for administration at a dose of 100 mg once a day in August 2011. A use-results survey on STFX 100 mg/day was performed from Dece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::02127b721598461bfc2481e58ef4699e
https://pubmed.ncbi.nlm.nih.gov/25163251
https://pubmed.ncbi.nlm.nih.gov/25163251
Autor:
Akiko Shiina, Yoshitaka Sogawa, Mizuki Takahashi, Masashi Hasegawa, Tsuyoshi Mikkaichi, Kiyoshi Mizukami, Kazuki Hirahara, Shigeki Sasaki, Tomoko Takahashi, Toshiharu Yoshino, Taiji Goto, Osamu Suzuki, Naoki Nakao
Publikováno v:
Bioorganicmedicinal chemistry. 21(22)
5-Carbamoyl-2-phenylpyrimidine derivative 2 has been identified as a phosphodiesterase 4 (PDE4) inhibitor with moderate PDE4B inhibitory activity (IC50=200 nM). Modification of the carboxylic acid moiety of 2 gave N-neopentylacetamide derivative 10f,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48d11496065fc1ddc96fda76304385b5
https://pubmed.ncbi.nlm.nih.gov/24094436
https://pubmed.ncbi.nlm.nih.gov/24094436
Publikováno v:
Comparative biochemistry and physiology. Part D, Genomicsproteomics. 1(1)
We investigated the intestinal microflora of coastal fish including Takifugu niphobles using both culture techniques and library cloning. As a result, the numbers of bacteria appeared on agar media were 1.0x10(4) to 1.4x10(9) CFU/g (colony forming un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7744b743453d9954fa2c25b18c43a2f1
https://pubmed.ncbi.nlm.nih.gov/20483242
https://pubmed.ncbi.nlm.nih.gov/20483242