Zobrazeno 1 - 10
of 164
pro vyhledávání: '"Akiko, Hatori"'
Autor:
Zhen Chen, Wakana Mori, Jian Rong, Michael A. Schafroth, Tuo Shao, Richard S. Van, Daisuke Ogasawara, Tomoteru Yamasaki, Atsuto Hiraishi, Akiko Hatori, Jiahui Chen, Yiding Zhang, Kuan Hu, Masayuki Fujinaga, Jiyun Sun, Qingzhen Yu, Thomas L. Collier, Yihan Shao, Benjamin F. Cravatt, Lee Josephson, Ming-Rong Zhang, Steven H. Liang
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 6, Pp 1686-1695 (2021)
As a serine hydrolase, monoacylglycerol lipase (MAGL) is principally responsible for the metabolism of 2-arachidonoylglycerol (2-AG) in the central nervous system (CNS), leading to the formation of arachidonic acid (AA). Dysfunction of MAGL has been
Externí odkaz:
https://doaj.org/article/6647b3af1e7f460aab63220f173d99be
Autor:
Kazunori Kawamura, Wakana Mori, Masayuki Fujinaga, Tomoteru Yamasaki, Yiding Zhang, Hidekatsu Wakizaka, Akiko Hatori, Lin Xie, Katsushi Kumata, Takayuki Ohkubo, Yusuke Kurihara, Masanao Ogawa, Nobuki Nengaki, Ming-Rong Zhang
Publikováno v:
EJNMMI Radiopharmacy and Chemistry, Vol 4, Iss 1, Pp 1-13 (2019)
Abstract Background Neuropeptide Y (NPY) has been implicated in a wide variety of physiological processes, including feeding, learning, memory, emotion, cardiovascular homeostasis, hormone secretion, and circadian rhythms. NPY Yl receptor (NPY Y1-R)
Externí odkaz:
https://doaj.org/article/33b5cf6272b34a589f88e299c9316311
Autor:
Tomoteru, Yamasaki, Akiko, Hatori, Zhang, Yiding, Kurihara, Yusuke, Masanao, Ogawa, Hidekatsu, Wakizaka, Rong, Jian, Lu, Wang, Liang, Huan, Zhang, Ming-Rong
Publikováno v:
Theranostics. 11(19):9492-9502
Hypoxia caused by ischemia induces acidosis and neuroexcitotoxicity, resulting in neuronal death in the central nervous system (CNS). Monoacylglycerol lipase (MAGL) is a modulator of 2-arachidonoylglycerol (2-AG), which is involved in retrograde inhi
Autor:
Yiding Zhang, Jiahui Chen, Atsuto Hiraishi, Steven H. Liang, Tomoteru Yamasaki, Ming-Rong Zhang, Benjamin F. Cravatt, Wakana Mori, Lee Josephson, Richard Van, Jian Rong, Tuo Shao, Masayuki Fujinaga, Michael A. Schafroth, Akiko Hatori, Thomas Lee Collier, Jiyun Sun, Qingzhen Yu, Kuan Hu, Zhen Chen, Yihan Shao, Daisuke Ogasawara
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 6, Pp 1686-1695 (2021)
As a serine hydrolase, monoacylglycerol lipase (MAGL) is principally responsible for the metabolism of 2-arachidonoylglycerol (2-AG) in the central nervous system (CNS), leading to the formation of arachidonic acid (AA). Dysfunction of MAGL has been
Autor:
Wakana, Mori, Kurihara, Yusuke, Tomoteru, Yamasaki, Akiko, Hatori, Zhang, Yiding, Masayuki, Fujinaga, Zhang, Ming-Rong
Publikováno v:
Nuclear Medicine and Biology.
Objectives: Monoacylglycerol lipase (MAGL) is an attractive target in development of pharmaceuticals for central nervous system disorders and neuroinflammation. So far, to visualize MAGL, we have developed several irreversible-type PET ligands [1,2].
Autor:
Chen, Zhen, Mori, Wakana, Rong, Jian, A. Schafroth, Michael, Shao, Tuo, S. Van, Richard, Ogasawara, Daisuke, Yamasaki, Tomoteru, Hiraishi, Atsuto, Hatori, Akiko, Chen, Jiahui, Zhang, Yiding, Kuan, Hu, Fujinaga, Masayuki, Sun, Jiyun, Yu, Qingzhen, L. Collier, Thomas, Shao, Yihan, F. Cravatt, Benjamin, Josephson, Lee, Ming-Rong, Zhang, Liang, Huan, Wakana, Mori, Tomoteru, Yamasaki, Atsuto, Hiraishi, Akiko, Hatori, Masayuki, Fujinaga, Zhang, Ming-Rong
Publikováno v:
Acta Pharmaceutica Sinica B. 11(6):1686-1695
Monoacylglycerol lipase (MAGL) is a serine hydrolase, which metabolizes 2-arachidonoylglycerol (2-AG) to arachidonic acid (AA) in the central nervous system (CNS). Dysfunction of MAGL has been associated with multiple CNS disorders and symptoms, incl
Autor:
Xiaoyun Deng, Kuan Hu, Douglas J. Sheffler, Masayuki Fujinaga, Zhen Chen, Ming-Rong Zhang, Yihan Shao, Richard Van, Steven H. Liang, Wakana Mori, Nicholas D. P. Cosford, Xiaofei Zhang, Katsushi Kumata, Nobuki Nengaki, Tomoteru Yamasaki, Akiko Hatori, Masanao Ogawa, Lin Xie, Yiding Zhang, Hidekatsu Wakizaka
Publikováno v:
Journal of Medicinal Chemistry. 63:11469-11483
Metabotropic glutamate receptor 2 (mGlu2) is a known target for treating several central nervous system (CNS) disorders. To develop a viable positron emission tomography (PET) ligand for mGlu2, we identified new candidates 5a-i that are potent negati
Autor:
Yamasaki, Tomoteru, Zhang, Xiaofei, Kumata, Katsushi, Zhang, Yiding, Deng, Xiaoyun, Fujinaga, Masayuki, Chen, Zhen, Mori, Wakana, Kuan, Hu, Wakizaka, Hidekatsu, Hatori, Akiko, Xie, Lin, Ogawa, Masanao, Nengaki, Nobuki, Van, Richard, Shao, Yihan, J. Sheffler, Douglas, D. P. Cosford, Nicholas, Liang, Huan, Ming-Rong, Zhang, Tomoteru, Yamasaki, Katsushi, Kumata, Masayuki, Fujinaga, Wakana, Mori, Hidekatsu, Wakizaka, Akiko, Hatori, Lin, Xie, Masanao, Ogawa, Nobuki, Nengaki, Zhang, Ming-Rong
Publikováno v:
Journal of Medicinal Chemistry. 2020(63):11469-11483
Metabotropic glutamate receptor 2 (mGlu2) is a known target for treating several central nervous system (CNS) disorders. To develop a viable positron emission tomography (PET) ligand for mGlu2, we identified new candidates 5a–i that are potent nega
Autor:
Zhang, Xiaofei, Zhang, Yiding, Chen, Zhen, Shao, Tuo, Van, Richard, Kumata, Katsushi, Deng, Xiaoyun, Fu, Hualong, Yamasaki, Tomoteru, Rong, Jian, Kuan, Hu, Hatori, Akiko, Xie, Lin, Yu, Qingzhen, Ye, Weijian, Xu, Hao, J. Sheffler, Douglas, D. P. Cosford, Nicholas, Shao, Yihan, Tang, Pingping, Lu, Wang, Ming-Rong, Zhang, Liang, Huan, Katsushi, Kumata, Tomoteru, Yamasaki, Akiko, Hatori, Lin, Xie, Zhang, Ming-Rong
Publikováno v:
Theranostics. 10(24):11178-11196
Selective modulation of metabotropic glutamate receptor 2 (mGlu2) represents a novel therapeutic approach for treating brain disorders, including schizophrenia, depression, Parkinson’s disease (PD), Alzheimer’s disease (AD), drug abuse and addict
Autor:
Jiyun Sun, Yunfei Du, Jian Rong, Qingzhen Yu, Hao Xu, Masayuki Fujinaga, Lin Xie, Zhen Chen, Jiahui Chen, Katsushi Kumata, Thomas Lee Collier, Lee Josephson, Steven H. Liang, Tuo Shao, Xiaoyun Deng, Lu Wang, Yiding Zhang, Ming-Rong Zhang, Tomoteru Yamasaki, Akiko Hatori, Kuan Hu, Hualong Fu, Yihan Shao
Publikováno v:
Acta Pharmacologica Sinica. 42:491-498
N-methyl-D-aspartate receptors (NMDARs) play critical roles in the physiological function of the mammalian central nervous system (CNS), including learning, memory, and synaptic plasticity, through modulating excitatory neurotransmission. Attributed