Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Akiko, Furuta"'
Publikováno v:
Kyushu Plant Protection Research. 67:1-8
Autor:
Declan M. McLoughlin, Masanobu Ito, Toshihito Suzuki, Heii Arai, Tomoya Kinjo, Koichiro Ichimura, Akiko Furuta, Kuerban Bolati
Publikováno v:
Brain Research Bulletin. 128:92-97
The blood-brain barrier (BBB) plays important roles in both the physiological and pharmacological state of the brain. Transiently enhancing the permeability of the BBB may allow use of more types of medications for neuropsychiatric diseases. Several
Publikováno v:
Tetrahedron. 72:8393-8399
A new electrochemical method for the asymmetric oxidative dimerization of cinnamic acid derivatives has been developed. This method enabled the enantioselective syntheses of furofuran lignans, yangambin, sesamin and eudesmin.
Autor:
Haruhiko Akiyama, Hiroyuki Hino, Yuanzhe Li, Katsuhiko Shibuya, Akiko Furuta, Masashi Takanashi, Michiko Minegishi, Ito Kawakami, Nobutaka Hattori, Eizo Iseki, Yoshio Mitsuyama, Shinji Higashi, Koji Kasanuki, Heii Arai, Kiyoshi Sato, Kohshiro Fujisawa
Publikováno v:
Journal of the Neurological Sciences. 367:349-355
Clinical phenotypes of hereditary diffuse leukoencephalopathy with spheroids (HDLS), a familial progressive neurodegenerative disorder affecting the white matter of the brain, are heterogenous and may include behavioral and personality changes, memor
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1854:1010-1018
Impaired clearance of soluble Aβ (amyloid-β) promotes Aβ aggregation in brains with Alzheimer's disease (AD), while apolipoprotein-E (ApoE) in microglia mediates Aβ clearance. We studied the protease responsible for ApoE(4) degradation in human p
Autor:
Tomohiro Kabuta, Yasuo Uchiyama, Hisae Kikuchi, Yuuki Fujiwara, Hiromi Fujita, Akiko Furuta, Daisuke Yamada, Ichizo Nishino, Keiji Wada
Publikováno v:
The American Journal of Pathology. 185:1713-1723
Lysosome-associated membrane protein-2 ( LAMP-2 ) is the gene responsible for Danon disease, which is characterized by cardiomyopathy, autophagic vacuolar myopathy, and variable mental retardation. To elucidate the function of LAMP-2 in the central n
Autor:
Anthony Cooper, Glenda M. Halliday, Brett Garner, Karen E. Murphy, Adena S. Spiro, Akiko Furuta, Sarah K. Abbott, Amanda M. Gysbers, Tomohiro Kabuta
Publikováno v:
Movement Disorders. 30:1639-1647
Lysosomes are the primary catabolic compartment for the degradation of intracellular proteins through autophagy. The presence of abnormal intracellular α-synuclein-positive aggregates in Parkinson's disease (PD) indicates that the degradative capaci
Publikováno v:
Acta Neuropathologica. 129:391-398
Danon disease is an X-linked disorder clinically characterized by the triad of hypertrophic cardiomyopathy, myopathy, and intellectual disability. Cardiomyopathy is a severe and life-threatening problem, for which cardiac transplantation is the only
Autor:
Yoichi Matsunaga, Hiroshi Imagawa, Hironobu Takahashi, Midori Suenaga, Yoshio Tsuboi, Shinji Ouma, Michiru Wagatsuma, Akiko Furuta
Publikováno v:
Current Alzheimer Research. 11:745-754
The seeding of amyloid-β 40 (Aβ40) oligomers from monomers is the initial step of Aβ aggregation, and many reports have suggested that cholesterol enhances this step. We studied the potential of secosteroid vitamin D derivatives for Aβ40 aggregat
Autor:
Shu Aizawa, Akiko Furuta, Yuuki Fujiwara, Chiho Konya, Hisae Kikuchi, Kenko Uchida, Tomohiro Kabuta, Keiji Wada, Yusuke Hatanaka
Publikováno v:
Autophagy
Lysosomes contain various hydrolases that can degrade proteins, lipids, nucleic acids and carbohydrates. We recently discovered “RNautophagy,” an autophagic pathway in which RNA is directly taken up by lysosomes and degraded. A lysosomal membrane