Zobrazeno 1 - 10
of 200
pro vyhledávání: '"Akihito Yamaguchi"'
Autor:
Yoshimi MATSUMOTO, Seiji YAMASAKI, Kouhei HAYAMA, Ryota IINO, Hiroyuki NOJI, Akihito YAMAGUCHI, Kunihiko NISHINO
Publikováno v:
Proceedings of the Japan Academy. Series B, Physical and Biological Sciences, Vol 100, Iss 1, Pp 57-67 (2024)
Changes in expression levels of drug efflux pump genes, mexB and mexY, and porin gene oprD in Pseudomonas aeruginosa were investigated in this study. Fifty-five multidrug-resistant P. aeruginosa (MDRP) strains were compared with 26 drug-sensitive str
Externí odkaz:
https://doaj.org/article/c848b6dbb03745449f524ddfd03f1bd8
Autor:
Martijn Zwama, Seiji Yamasaki, Ryosuke Nakashima, Keisuke Sakurai, Kunihiko Nishino, Akihito Yamaguchi
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Multidrug transporters possess several drug binding sites. Here the authors describe a transport path specific for planar aromatic cations in the E. coli multi-drug transporter AcrB.
Externí odkaz:
https://doaj.org/article/cf87738eec424a5bb6b49a27e8fde79a
Publikováno v:
Journal of Lipid Research, Vol 57, Iss 11, Pp 2088-2094 (2016)
Sphingosine-1-phosphate (S1P) is present in the blood plasma and acts as a pivotal intercellular signal transmitter in the immune system by recruiting lymphocytes from the thymus and secondary lymphoid tissues. The plasma S1P concentration is maintai
Externí odkaz:
https://doaj.org/article/01d00bdb57944efd99481475aadb686b
Autor:
Martijn Zwama, Katsuhiko Hayashi, Keisuke Sakurai, Ryosuke Nakashima, Kimie Kitagawa, Kunihiko Nishino, Akihito Yamaguchi
Publikováno v:
Frontiers in Microbiology, Vol 8 (2017)
The overexpression of RND-type exporters is one of the main causes of multidrug resistance (MDR) in Gram-negative pathogens. In RND transporters, such as Escherichia coli's main efflux pump AcrB, drug efflux occurs in the porter domain, while protons
Externí odkaz:
https://doaj.org/article/b1ac10fa21bd4a1986eb55c987cd1699
Autor:
Yoshimi Matsumoto, Shouichi Sakakihara, Andrey Grushnikov, Kazuma Kikuchi, Hiroyuki Noji, Akihito Yamaguchi, Ryota Iino, Yasushi Yagi, Kunihiko Nishino
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0148797 (2016)
The recent global increase in the prevalence of antibiotic-resistant bacteria and lack of development of new therapeutic agents emphasize the importance of selecting appropriate antimicrobials for the treatment of infections. However, to date, the de
Externí odkaz:
https://doaj.org/article/3bcf522f930b4e97bbd53c176384cac0
Autor:
Nobuyoshi Kobayashi, Tsuyoshi Nishi, Takahiro Hirata, Akio Kihara, Takamitsu Sano, Yasuyuki Igarashi, Akihito Yamaguchi
Publikováno v:
Journal of Lipid Research, Vol 47, Iss 3, Pp 614-621 (2006)
Sphingosine 1-phosphate (S1P) is accumulated in platelets and released on stimulation by thrombin or Ca2+. Thrombin-stimulated S1P release was inhibited by staurosporin, whereas Ca2+-stimulated release was not. When the platelet plasma membrane was p
Externí odkaz:
https://doaj.org/article/b023379be8484c3c9a7ed59f617311ce
Autor:
Masaya Yamaguchi, Yutaka Terao, Yuka Mori-Yamaguchi, Hisanori Domon, Yuuki Sakaue, Tetsuya Yagi, Kunihiko Nishino, Akihito Yamaguchi, Victor Nizet, Shigetada Kawabata
Publikováno v:
PLoS ONE, Vol 9, Iss 1 (2014)
Externí odkaz:
https://doaj.org/article/10540150df9a4948a30b610ee3afa7f6
Autor:
Masaya Yamaguchi, Yutaka Terao, Yuka Mori-Yamaguchi, Hisanori Domon, Yuuki Sakaue, Tetsuya Yagi, Kunihiko Nishino, Akihito Yamaguchi, Victor Nizet, Shigetada Kawabata
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e77282 (2013)
Streptococcus pneumoniae, a Gram-positive bacterium, is a major cause of invasive infection-related diseases such as pneumonia and sepsis. In blood, erythrocytes are considered to be an important factor for bacterial growth, as they contain abundant
Externí odkaz:
https://doaj.org/article/f504770221f84531925b1361b3f6211d
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e38941 (2012)
Sphingosine-1-phosphate (S1P), a sphingolipid metabolite that is produced inside the cells, regulates a variety of physiological and pathological responses via S1P receptors (S1P1-5). Signal transduction between cells consists of three steps; the syn
Externí odkaz:
https://doaj.org/article/fe4c22080eab4544ac033ebafff191d7
Autor:
Yoshimi Matsumoto, Kohei Hayama, Shouichi Sakakihara, Kunihiko Nishino, Hiroyuki Noji, Ryota Iino, Akihito Yamaguchi
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e18547 (2011)
Fluorescein-di-β-D-galactopyranoside (FDG), a fluorogenic compound, is hydrolyzed by β-galactosidase in the cytoplasm of Escherichia coli to produce a fluorescent dye, fluorescein. We found that both FDG and fluorescein were substrates of efflux pu
Externí odkaz:
https://doaj.org/article/d475f5f420994c27a4ac48dbc610a1b1