Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Akihito Ogasawara"'
Publikováno v:
Pharmacology Research & Perspectives, Vol 11, Iss 3, Pp n/a-n/a (2023)
Abstract Dersimelagon (formerly MT‐7117) is a novel, orally administered nonpeptide small molecule selective agonist for melanocortin 1 receptor currently being investigated for the treatment of erythropoietic protoporphyria, X‐linked protoporphy
Externí odkaz:
https://doaj.org/article/8c0fa5619e474aa9b0fcfcd6b9ae3e38
Autor:
Kei Ogawa, Ryosuke Ide, Kirstine Belongie, Minoru Tsuda, Hiroki Kawanishi, Renli Teng, Akihito Ogasawara
Publikováno v:
Clinical Pharmacology in Drug Development. 12:493-501
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6cacd3309af4b1f507beaffb1135c808
https://doi.org/10.1002/cpdd.1235
https://doi.org/10.1002/cpdd.1235
Publikováno v:
Pharmacology Research & Perspectives. 11
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4a7208c195e37d3204e385b73a267dd
https://doi.org/10.1002/prp2.1084
https://doi.org/10.1002/prp2.1084
Autor:
Akihito Ogasawara, Kei Ogawa, Ryosuke Ide, Yuka Ikenaga, Chie Fukunaga, Satoshi Nakayama, Minoru Tsuda
Publikováno v:
European Journal of Clinical Pharmacology.
Purpose To describe outcomes from the first-in-human study of dersimelagon, an investigational oral selective MC1R agonist, under development for the treatment of erythropoietic protoporphyria (EPP) and X-linked protoporphyria (XLP). Methods In this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::baea94a56d47c2cc3e0cfda5803e8f8f
https://doi.org/10.1007/s00228-023-03476-6
https://doi.org/10.1007/s00228-023-03476-6
Autor:
Yoshinobu Nakamaru, Akihito Ogasawara, Tomohisa Nakada, Koki Kojima, Hiroshi Yamazaki, Hidetoshi Shimizu, Kosuke Yoshida
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 47(2)
Predicting the pharmacokinetics of compounds in humans is an important part of the drug development process. In this study, the plasma concentration profiles of 10 marketed compounds exhibiting two-phase elimination after intravenous administration i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7450a98e524d761c243ac3d5410575f7
https://pubmed.ncbi.nlm.nih.gov/30420404
https://pubmed.ncbi.nlm.nih.gov/30420404
Publikováno v:
Drug Metabolism and Disposition. 37:2127-2136
Irreversible inhibition, characterized as mechanism-based inhibition (MBI), of cytochrome P450 in drugs has to be avoided for their safe use. A comprehensive assessment of drug-drug interaction (DDI) potential is important during the drug discovery p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59ada724278c9412cfa34e6543ec7d36
https://doi.org/10.1124/dmd.109.028969
https://doi.org/10.1124/dmd.109.028969
Autor:
Ayumi Ueda, Kazuo Nii, Akihito Ogasawara, Takahiro Yoshikawa, Masahiro Utoh, Toshiyuki Kume, Koichiro Fukuzaki
Publikováno v:
Drug Metabolism and Disposition. 37:122-128
Drugs with potential drug-drug interactions (DDIs) may have a limited scope of use and, at worst, may have to be withdrawn from the market. Therefore, during the drug discovery process it is important to select drug candidates with reduced potential
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49dd1e871418abe0a48ff8579f5ee8e7
https://doi.org/10.1124/dmd.108.022574
https://doi.org/10.1124/dmd.108.022574
Publikováno v:
Drug Metabolism and Disposition. 35:410-418
Because the expression of drug-metabolizing enzymes and drug efflux transporters has been shown in the intestine, the contribution of this tissue to the first-pass effect has become of significant interest. Consequently, a comprehensive understanding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20bdb22e58188530144a5f9a147c4e38
https://doi.org/10.1124/dmd.106.011288
https://doi.org/10.1124/dmd.106.011288
Autor:
Akira Hara, Toshihiro Nakayama, Kumiko Sato, Masayuki Nakanishi, Akihito Ogasawara, Yoshihiro Deyashiki, Yoshiyuki Miyabe
Publikováno v:
The Biochemical journal. 299
Human liver contains two dihydrodiol dehydrogenases, DD2 and DD4, associated with 3 alpha-hydroxysteroid dehydrogenase activity. We have raised polyclonal antibodies that cross-reacted with the two enzymes and isolated two 1.2 kb cDNA clones (C9 and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7da544ee10100ce75c47080ab869aa88
https://pubmed.ncbi.nlm.nih.gov/8172617
https://pubmed.ncbi.nlm.nih.gov/8172617
Autor:
YOSHIHIRO, DEYASHIKI, AKIHITO, OGASAWARA, TOSHIHIRO, NAKAYAMA, MASAYUKI, NAKANISHI, YOSHIYUKI, MIYABE, KUMIKO, SATOH, AKIRA, HARA
Publikováno v:
岐阜藥科大學紀要 = The annual proceedings of Gifu College of Pharmacy. 44:83
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=jairo_______::56c8c60e71a068211d25b51202b96c10
http://id.nii.ac.jp/1076/00010203/
http://id.nii.ac.jp/1076/00010203/