Výsledky vyhledávání - "Akihito Kikukawa"

Tissue concentration of adriamycin and adriamycinoxidized dextran conjugate in tumor bearing rats and mice

Autor: Kouichi Yamanouchi, Akihito Kikukawa, Shigeru Tsukagoshi, Kohji Munechika, Yasuo Ueda, Kazumasa Yokoyama

Publikováno v: Drug Delivery System. 5:255-260

We have developed an adriamycin-oxidized dextran conjugate (ADM-OXD) which was found to possess not only higher antitumor activity but also less animal toxicity than ADM. It appeared that improvement of the therapeutic index of ADM-OXD was due to its

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::327eb776560682b5dcb594a6fc5eec8d
https://doi.org/10.2745/dds.5.255

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Comparison of efficacy, toxicity and pharmacokinetics of free adriamycin and adriamycin linked to oxidized dextran in rats

Autor: Kazumasa Yokoyama, Yoshiaki Kanoh, Koji Munechika, Yasuo Ueda, Kouichi Yamanouchi, Akihito Kikukawa

Publikováno v: Chemicalpharmaceutical bulletin. 37(6)

Adriamycin linked to oxidized dextran (ADM-OXD) via Schiff's base formation was compared with free adriamycin with regard to antitumor activity, acute toxicity and plasma pharmacokinetics in rats following i.v. administration. ADM-OXD showed higher a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7acfbb4b8fb65cc4453d37b8df46cae8
https://pubmed.ncbi.nlm.nih.gov/2476250

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