Výsledky vyhledávání - "Akihito Hirabayashi"

Structure–activity relationship studies of imidazo[1,2-c]pyrimidine derivatives as potent and orally effective Syk family kinases inhibitors

Autor: Hiroaki Kobayashi, Motoyasu Ozawa, Harunobu Mukaiyama, Akihito Hirabayashi, Satoko Nakayama, Hiroaki Shiohara, Keiko Misawa, Eiichi Tsuji, Keiji Miyazawa, Masayuki Isaji, Hideki Ohnota

Publikováno v: Bioorganic & Medicinal Chemistry. 16:9247-9260

Spleen tyrosine kinase (Syk) and zeta-associated protein kinase of 70 kDa (ZAP-70) are members of the Syk family and non-receptor-type protein tyrosine kinases, which play crucial roles in B- and T-cell activation. Therefore, a Syk family tyrosine ki

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86e8455692c661f7759296dc68fb8891
https://doi.org/10.1016/j.bmc.2008.09.015

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A novel Syk family kinase inhibitor: Design, synthesis, and structure–activity relationship of 1,2,4-triazolo[4,3-c]pyrimidine and 1,2,4-triazolo[1,5-c]pyrimidine derivatives

Autor: Harunobu Mukaiyama, Motoyasu Ozawa, Keiko Misawa, Satoko Nakayama, Keiji Miyazawa, Hiroaki Kobayashi, Hiroaki Shiohara, Masayuki Isaji, Akihito Hirabayashi, Hideki Ohnota

Publikováno v: Bioorganic & Medicinal Chemistry. 16:7347-7357

Splenic tyrosine kinase (Syk) family kinases, which are members of the protein tyrosine kinase family, play crucial roles in immune responses, with Syk participating in B-cell activation and the zeta-associated protein 70 kDa (ZAP-70) kinase being in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0e323a73ad0a7353bf5b24b4fcdd0cd
https://doi.org/10.1016/j.bmc.2008.06.017

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β3-Adrenoceptor agonists for the treatment of frequent urination and urinary incontinence: 2-[4-(2-{[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]amino}ethyl)phenoxy]-2-methylpropionic acid

Autor: Nobuyuki Tanaka, Akihito Hirabayashi, Masuo Akahane, Hideyuki Muranaka, Harunobu Mukaiyama, Takehiro Ishikawa, Satoshi Akahane, Tetsuro Tamai

Publikováno v: Bioorganic & Medicinal Chemistry. 9:3265-3271

In a search for novel analogues of beta(3)-adrenoceptor (AR) agonists relaxing the bladder for treatment of urinary dysfunction, 2-[4-(2-[[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]amino]ethyl)phenoxy]-2-methylpropionic acids (1a-e), into w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3d0bd882d9556158983a33f96ef8022
https://doi.org/10.1016/s0968-0896(01)00240-1

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Discovery of Novel N-Phenylglycine Derivatives as Potent and Selective β3-Adrenoceptor Agonists for the Treatment of Frequent Urination and Urinary Incontinence

Autor: Hideyuki Rasukasasu Azumino Muranaka, Satoshi Akahane, Harunobu Mukaiyama, Hiroshi Miyata, Masuo Akahane, Nobuyuki Tanaka, Akihito Hirabayashi, Tetsuro Tamai

Publikováno v: Journal of Medicinal Chemistry. 44:1436-1445

With a novel assay using isolated ferret detrusor to estimate beta(3)-adrenoceptor agonistic activity, we found that a series of glycine derivatives of ritodrine, a beta(2)-adrenoceptor agonist, are potent beta(3)-adrenoceptor agonists, with excellen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9860d86b1966e5acb9590bdfc6160fe1
https://doi.org/10.1021/jm000455z

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Preparation of chiral building blocks for synthesis of Aconitium alkaloids

Autor: Masataka Ihara, Keiichiro Fukumoto, Y. Tokunaga, Akihito Hirabayashi, M. Suzuki

Publikováno v: Tetrahedron: Asymmetry. 6:2053-2058

Treatment of meso -diols 3 and 6 with CCL and vinyl acetate without solvent produced the AE part of Aconitium alkaloids 2 and 7 in 68% and 75% yields, respectively, with > 96% e.e. Quantitative formations of their MTPA esters 4 and 8 were achieved by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::46cd3b9ad6f23612cfb1a8bcbce4ca3f
https://doi.org/10.1016/0957-4166(95)00267-s

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ChemInform Abstract: Enantioselective Synthesis of 6-Oxygenated Atisine Derivative via Intramolecular Double Michael Reaction

Autor: Akihito Hirabayashi, Masataka Ihara, Keiichiro Fukumoto, Nobuaki Taniguchi

Publikováno v: ChemInform. 23

An enantioselective synthesis of a 6-oxygenated atisine derivative 20 is described. The atisine skeleton 18 was stereoselectively constructed by the intramolecular double Michael reaction of the enone ester 16, derived, through the aldehyde 3, from t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ca3cb0afda1ec7f869dd56c2be6f6d55
https://doi.org/10.1002/chin.199240258

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Enantioselective synthesis of 6-oxygenated atisine derivative via intramolecular double Michael reaction

Autor: Masataka Ihara, Keiichiro Fukumoto, Akihito Hirabayashi, Nobuaki Taniguchi

Publikováno v: Tetrahedron. 48:5089-5098

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5740b93cfd511480f8fb121983576180
https://doi.org/10.1016/s0040-4020(01)90119-x

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