Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Akihisa Nakagawa"'
Autor:
Jason L.J. Lin, Akihisa Nakagawa, Riley Skeen-Gaar, Wei-Zen Yang, Pei Zhao, Zhe Zhang, Xiao Ge, Shohei Mitani, Ding Xue, Hanna S. Yuan
Publikováno v:
Cell Reports, Vol 16, Iss 2, Pp 279-287 (2016)
Endonuclease G (EndoG) is a mitochondrial protein that is released from mitochondria and relocated into the nucleus to promote chromosomal DNA fragmentation during apoptosis. Here, we show that oxidative stress causes cell-death defects in C. elegans
Externí odkaz:
https://doaj.org/article/598178a549e3416183ca2c8fc0d497fd
Autor:
Haimin Li, Donna William, Ding Xue, Shohei Mitani, Riley Robert Skeen-Gaar, Qinghua Zhou, Eui Seung Lee, Akihisa Nakagawa, Byung-Ho Kang, Brian L. Harry, Hanzeng Li, Yuji Suehiro, Hanna S. Yuan, Jason L.J. Lin
Publikováno v:
Science. 353:394-399
Eliminating paternal mitochondria During fertilization, the oocyte and sperm each bring their mitochondria to the union. Shortly afterward, the paternal mitochondria are degraded, and only the maternal mitochondria are conveyed to the progeny. Zhou e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::498844a97f3779c71f6a7e6edb4d0823
https://doi.org/10.1126/science.aaf4777
https://doi.org/10.1126/science.aaf4777
Autor:
Shohei Mitani, Hanna S. Yuan, Xiao Ge, Pei Zhao, Wei-Zen Yang, Zhe Zhang, Jason L.J. Lin, Riley Robert Skeen-Gaar, Ding Xue, Akihisa Nakagawa
Publikováno v:
Cell Reports, Vol 16, Iss 2, Pp 279-287 (2016)
Summary Endonuclease G (EndoG) is a mitochondrial protein that is released from mitochondria and relocated into the nucleus to promote chromosomal DNA fragmentation during apoptosis. Here, we show that oxidative stress causes cell-death defects in C.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbb47bdb80e492e7145efc5bcb74aec8
https://doi.org/10.1016/j.celrep.2016.05.090
https://doi.org/10.1016/j.celrep.2016.05.090
Caspase-activated phosphoinositide binding by CNT-1 promotes apoptosis by inhibiting the AKT pathway
Publikováno v:
Nature structural & molecular biology
Inactivation of cell-survival factors is a crucial step in apoptosis. The phosphoinositide 3-kinase (PI3K)-AKT signaling pathway promotes cell growth, proliferation and survival, and its deregulation causes cancer. How this pathway is suppressed to p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3b69cc0a67104a116dff1e2373f5d49
https://doi.org/10.1038/nsmb.2915
https://doi.org/10.1038/nsmb.2915
Publikováno v:
Cell chemical biology. 24(3)
Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most commonly used drugs in the world. While the role of NSAIDs as cyclooxygenase (COX) inhibitors is well established, other targets may contribute to anti-inflammation. Here we report cas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b2fe5a8b3c8c28fdb8aaf2e96b10309
https://pubmed.ncbi.nlm.nih.gov/28238723
https://pubmed.ncbi.nlm.nih.gov/28238723
Autor:
Massimo A. Hilliard, Ding Xue, Brent Neumann, Rosina Giordano-Santini, Casey Linton, Zehra C. Abay, Akihisa Nakagawa, Eui Seung Lee, Sean Coakley
Publikováno v:
Frontiers in Cellular Neuroscience. 10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e46a2c832ce05fbfb4fa5029202b1ce
Publikováno v:
Science. 328:327-334
Deadly Diced DNA Mammalian cells undergoing programmed cell death, or apoptosis, destroy DNA with the deoxyribonuclease known as DFF40. Cells of the worm Caenorhabditis elegans also undergo cell death but they do so without a DFF40 enzyme. Nakagawa e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::01c48f3c658ba503178ddc520beb4694
https://doi.org/10.1126/science.1182374
https://doi.org/10.1126/science.1182374
Publikováno v:
Nature structural & molecular biology
Inhibitor of apoptosis (IAP) proteins have a crucial role in apoptosis, through negative regulation of caspases in species from fruitflies to mammals. In Caenorhabditis elegans, however, no IAP homolog or caspase inhibitor has been identified, callin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbc453433d50711e5ddb0d180f89473f
https://doi.org/10.1038/nsmb.1488
https://doi.org/10.1038/nsmb.1488
Autor:
Brian L. Harry, Yue Wang, Yu-Zen Chen, Xudong Chen, Akihisa Nakagawa, Hongyan Guo, Ding Xue, Eui Seung Lee
Publikováno v:
Nature structuralmolecular biology. 23(11)
Perinuclear localization of CED-3 zymogen in C. elegans germ cells and interaction with nuclear-pore protein NPP-14 inhibit autocatalytic activation of CED-3, a central event in apoptosis. Caspases are cysteine proteases with critical roles in apopto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14d096103407471983923b41284261d0
https://pubmed.ncbi.nlm.nih.gov/27723735
https://pubmed.ncbi.nlm.nih.gov/27723735
Publikováno v:
Cell cycle (Georgetown, Tex.). 14(12)
Activation of caspases is an integral part of the apoptotic cell death program. Collectively, these proteases target hundreds of substrates, leading to the hypothesis that apoptosis is “death by a thousand cuts”. Recent work, however, has demonst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72691afcd8001f2414d5b062dc6bf72e
https://pubmed.ncbi.nlm.nih.gov/25853217
https://pubmed.ncbi.nlm.nih.gov/25853217