Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Akihisa Maeda"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-8 (2024)
Abstract After total knee arthroplasty (TKA), approximately 20% of patients experience persistent postoperative pain (PPP). Although preoperative and postoperative pain intensity is a relevant factor, more detailed description of pain is needed to de
Externí odkaz:
https://doaj.org/article/c9b3ce109b76486bb6fdd49a440998f7
Autor:
Shuichi Hamada, Miyuki Shigano, Satoru Kawakami, Maya Ueda, Hajime Sui, Katsuya Yamada, Soichiro Hagio, Ayaka Momonami, Akihisa Maeda, Yukari Terashima, Wakako Ohyama, Takeshi Morita, Makoto Hayashi
Publikováno v:
Genes and Environment, Vol 41, Iss 1, Pp 1-8 (2019)
Abstract Background The repeated-dose liver micronucleus (RDLMN) assay is an effective and important in vivo test for detecting genotoxic compounds, particularly for those that require metabolic activation to show genotoxicity. In a collaborative stu
Externí odkaz:
https://doaj.org/article/c18356cee9e44b748aa005238a282ea6
Autor:
Tetsuo Nakabayashi, Akihisa Maeda, Takashi Dan, Kenji Murano, Nagahisa Yamaoka, Toshio Miyata, Hidehiko Kodama, Kanji Meguro
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:809-813
Novel plasminogen activator inhibitor-1 (PAI-1) inhibitors with highly improved oral bioavailability were discovered by structure-activity relationship studies on N-acyl-5-chloroanthranilic acid derivatives. Because lipophilic N-acyl groups seemed to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3839236b25a26fdf28dc0b6693b114bb
https://doi.org/10.1016/j.bmcl.2017.11.016
https://doi.org/10.1016/j.bmcl.2017.11.016
Autor:
Yoshiji Asaoka, Hiromi Tsuchiyama, Mayumi Nakajima, Mayu Mutsuga, Tomoya Miyoshi, Akihisa Maeda, Keiyu Oshida, Kei Takahashi, Mika Kitsukawa, Yohei Miyamoto
Publikováno v:
Toxicology Letters. 280:133-141
The murine local lymph node assay (LLNA) is widely used to test chemicals to induce skin sensitization. Exposure of mouse auricle skin to a sensitizer results in proliferation of local lymph node T cells, which has been measured by in vivo incorporat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b38006cfe2c7995bb8c65f0b9ed0d14f
https://doi.org/10.1016/j.toxlet.2017.08.009
https://doi.org/10.1016/j.toxlet.2017.08.009
Publikováno v:
Bulletin of the Chemical Society of Japan. 90:178-187
Treatment of 4,6-di(substituted)amino-1,2-dihydro-1,3,5-triazine derivative (5) with sodium chloride in a bilayer system consisting of toluene and water gave its hydrochloride (6) in the toluene layer and sodium hydroxide in the aqueous layer. Simila
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c1218529f8196671fbe90ba2e9a4cefd
https://doi.org/10.1246/bcsj.20160329
https://doi.org/10.1246/bcsj.20160329
Autor:
Ayaka Momonami, Soichiro Hagio, Satoru Kawakami, Akihisa Maeda, Hajime Sui, Miyuki Shigano, Katsuya Yamada, Takeshi Morita, Wakako Ohyama, Maya Ueda, Shuichi Hamada, Makoto Hayashi, Yukari Terashima
Publikováno v:
Genes and Environment
Genes and Environment, Vol 41, Iss 1, Pp 1-8 (2019)
Genes and Environment, Vol 41, Iss 1, Pp 1-8 (2019)
Background The repeated-dose liver micronucleus (RDLMN) assay is an effective and important in vivo test for detecting genotoxic compounds, particularly for those that require metabolic activation to show genotoxicity. In a collaborative study by the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e819351cf59143d8aceafcbd6d3ec949
https://doi.org/10.1186/s41021-019-0128-5
https://doi.org/10.1186/s41021-019-0128-5
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 811:91-96
The Pig-a assay is a novel method to assess the in vivo mutagenicity of compounds, and it is expected to be useful for the detection of genotoxicity. In this study, to assess the performance of the Pig-a assay targeting red blood cells (RBCs; RBC Pig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02c878d302c31f3d0c98090d9abe518f
https://doi.org/10.1016/j.mrgentox.2015.12.006
https://doi.org/10.1016/j.mrgentox.2015.12.006
Autor:
Hideki Adachi, Yoshifumi Uno, Yuki Okada, Kunio Wada, Yosuke Ogiwara, Shigeharu Muto, Katsuyoshi Horibata, Shuichi Hamada, Mika Yamamoto, Akihisa Maeda, Eri Tsutsumi, Masami Yamada, Yasuaki Uematsu, Hironao Takasawa, Masamitsu Honma, Takeshi Morita, Ikuma Yoshida, Satoru Itoh, Hisako Hori, Shiho Nakayama, Hisakazu Sanada, Akiko Ukai, Miyuki Shigano, Kazunori Narumi, Naomi Koyama, Takafumi Kimoto, Yuta Suzuki, Daishiro Miura, Takayuki Fukuda, Yohei Fujiishi, Ken Goto, Satsuki Chikura, Ryuta Kikuzuki, Takahiro Kyoya
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 811:3-15
The in vivo mutation assay using the X-linked phosphatidylinositol glycan class A gene (Pig-a in rodents, PIG-A in humans) is a promising tool for evaluating the mutagenicity of chemicals. Approaches for measuring Pig-a mutant cells have focused on p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ece3a3f5c327f782fb31dcbf00bbf454
Autor:
George E. Johnson, Mika Yamamoto, Hironao Takasawa, Kunio Wada, Katsuyoshi Horibata, Ryuta Kikuzuki, Ikuma Yoshida, Kazunori Narumi, Takahiro Kyoya, Eri Tsutsumi, Akihisa Maeda, Hideki Adachi, Takafumi Kimoto, Yuta Suzuki
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 811:135-139
The reproducibility of the in vivo Pig-a gene mutation test system was assessed across 13 different Japanese laboratories. In each laboratory rats were exposed to the same dosing regimen of N-nitroso-N-ethylurea (ENU), and red blood cells (RBCs) and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05bd34ff92a845c9b6c6cda70e8b4c68
https://doi.org/10.1016/j.mrgentox.2016.04.004
https://doi.org/10.1016/j.mrgentox.2016.04.004
Autor:
Emiko Okada, Akihisa Maeda, Shuichi Hamada, Yohei Miyamoto, Yasuyoshi Ishikawa, Ayami Tadakuma, Masakatsu Natsume, Shizuyo Sutou, Hiroshi Honda, Kazunori Narumi, Tomohiro Sakuma, Akiko Koeda, Izumi Hanahara, Takashi Watanabe, Madoka Nakajima, Yohei Fujiishi, Michiasa Hirayama, Hisakazu Sanada, Keiyu Oshida, Takayoshi Suzuki, Mahoko Kido, Wakako Ohyama, Rina Minamiguchi, Chie Furihata
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 747:164-175
The general aim of the present study is to discriminate between mouse genotoxic and non-genotoxic hepatocarcinogens via selected gene expression patterns in the liver as analyzed by quantitative real-time PCR (qPCR) and statistical analysis. qPCR was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6dd36e0bc2fb631495242cebec60205
https://doi.org/10.1016/j.mrgentox.2012.04.011
https://doi.org/10.1016/j.mrgentox.2012.04.011