Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Akihiro TASAKA"'
Publikováno v:
AEROSPACE TECHNOLOGY JAPAN, THE JAPAN SOCIETY FOR AERONAUTICAL AND SPACE SCIENCES. 12:25-30
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c866ad4825d1e6bc88b90471280b7e1c
https://doi.org/10.2322/astj.12.25
https://doi.org/10.2322/astj.12.25
Autor:
Masami Kusaka, Junzo Takahashi, Masuo Yamaoka, Satoru Asahi, Takahito Hara, Takenori Hitaka, Tomohiro Kaku, Toshiyuki Takeuchi, Hiroshi Miki, Akihiro Tasaka
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 129:115-128
Surgical or pharmacologic methods to control gonadal androgen biosynthesis are effective approaches in the treatment of a variety of non-neoplastic and neoplastic diseases. For example, androgen ablation and its consequent reduction in circulating le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e25cb51d6b392d67dbb96e8b943c392
https://doi.org/10.1016/j.jsbmb.2012.01.001
https://doi.org/10.1016/j.jsbmb.2012.01.001
Autor:
Nobuyuki Matsunaga, Akihiro Tasaka, Satoru Asahi, Mari Adachi, Takahito Hara, Toshimasa Tanaka, Teruaki Okuda, Akio Ojida, Takenori Hitaka, Shuichi Furuya, Tomohiro Kaku, Masami Kusaka, Masuo Yamaoka
Publikováno v:
Bioorganic & Medicinal Chemistry. 19:6383-6399
A novel naphthylmethylimidazole derivative 1 and its related compounds were identified as 17,20-lyase inhibitors. Based on the structure–activity relationship around the naphthalene scaffold and the results of a docking study of 1a in the homology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d9ae1020bfeecd91e9f7d00f654b7c3
https://doi.org/10.1016/j.bmc.2011.08.066
https://doi.org/10.1016/j.bmc.2011.08.066
Autor:
Toshimasa Tanaka, Saori Tsujimoto, Tomohiro Kaku, Masuo Yamaoka, Akihiro Tasaka, Masami Kusaka, Nobuyuki Matsunaga, Takahito Hara
Publikováno v:
Bioorganic & Medicinal Chemistry. 19:2428-2442
A novel series of biphenylylmethylimidazole derivatives and related compounds were synthesized as inhibitors of 17,20-lyase, a key enzyme in the production of steroid hormones, and their biological activities were evaluated. In an attempt to identify
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f00b6983c19e8de9a9dd65127d0511aa
https://doi.org/10.1016/j.bmc.2011.02.009
https://doi.org/10.1016/j.bmc.2011.02.009
Autor:
Nobuyuki Matsunaga, Masuo Yamaoka, Takahito Hara, Akihiro Tasaka, Toshimasa Tanaka, Tomohiro Kaku, Akio Ojida, Masami Kusaka
Publikováno v:
Bioorganic & Medicinal Chemistry. 12:4313-4336
A series of 1- and 4-(2-naphthylmethyl)-1H-imidazoles (3 and 4) has been synthesized and evaluated as C17,20-lyase inhibitors. Several 6-methoxynaphthyl derivatives showed potent C17,20-lyase inhibition, suppression of testosterone biosynthesis in ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5f29737929a447a9d54b77ba2eddaff
https://doi.org/10.1016/j.bmc.2004.06.016
https://doi.org/10.1016/j.bmc.2004.06.016
Publikováno v:
Tetrahedron: Asymmetry. 15:2021-2028
An asymmetric synthesis of the selective C 17,20 -lyase inhibitor 2 has been established in eight steps from 2,3-dihydroxynaphthalene 9 . The key steps are the enantioselective oxidation of ketone 17 to the chiral α-hydroxy ketone 18 and the diaster
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a8e1e04a65d4c83d24d0697e3c71260
https://doi.org/10.1016/j.tetasy.2004.05.044
https://doi.org/10.1016/j.tetasy.2004.05.044
Autor:
Masahiko Iwasaki, Masuo Yamaoka, Nobuyuki Matsunaga, Takahito Hara, Toshimasa Tanaka, Masami Kusaka, Tetsuya Aono, Akihiro Tasaka, Tomohiro Kaku, Fumio Itoh, Hiroshi Miki
Publikováno v:
Bioorganic & Medicinal Chemistry. 12:2251-2273
Novel nonsteroidal C(17,20)-lyase inhibitors were synthesized using de novo design based on its substrate, 17 alpha-hydroxypregnenolone, and several compounds exhibited potent C(17,20)-lyase inhibition. However, in vivo activities were found to be sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d9854d7fc1f1b0b27a638b08d8a76ce
https://doi.org/10.1016/j.bmc.2004.02.007
https://doi.org/10.1016/j.bmc.2004.02.007
Publikováno v:
Tetrahedron: Asymmetry. 15:1555-1559
An efficient stereocontrolled synthesis of the potent C17,20-lyase inhibitor, (1S)-1-(1H-imidazol-4-yl)-1-(6-methoxy-2-naphthyl)-2-methyl-1-propanol 1, has been established. The stereogenic center of 1 was successfully constructed by a highly diaster
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::40bfc74f8b2d313ed966c6fbb27b7d38
https://doi.org/10.1016/j.tetasy.2004.02.035
https://doi.org/10.1016/j.tetasy.2004.02.035
Autor:
William R. Roush, Karl A. Scheidt, Brad M. Savall, Glenn J. Fegley, Michael D. Wendt, Thomas D. Bannister, Akihiro Tasaka
Publikováno v:
Journal of the American Chemical Society. 124:6981-6990
A highly stereoselective total synthesis of (-)-bafilomycin A(1), the naturally occurring enantiomer of this potent vacuolar ATPase inhibitor, is described. The synthesis features the highly stereoselective aldol reaction of methyl ketone 8b and alde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9834088852ce32140d2c15435e825b0
https://doi.org/10.1021/ja017885e
https://doi.org/10.1021/ja017885e
Autor:
Tomohiro Kaku, Hitomi Yamasaki, Naohiro Kawaguchi, Masami Kusaka, Akihiro Tasaka, Masuo Yamaoka, Toshiyuki Takeuchi, Takenori Hitaka, Hiroshi Miki, Takahito Hara
Publikováno v:
Cancer Research. 70:DD01-03
Background: Recent studies suggest that residual adrenal androgen after castration could be responsible for the progression of castration-resistant prostate cancer (CRPC). To develop an effective therapy for CRPC that inhibits the production of adren
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::150f61e65f6504dfbf7f84361d9ec411
https://doi.org/10.1158/1538-7445.am10-dd01-03
https://doi.org/10.1158/1538-7445.am10-dd01-03