Zobrazeno 1 - 10
of 103
pro vyhledávání: '"Akihiro Nakaya"'
Autor:
Masataka Kikuchi, Akinori Miyashita, Norikazu Hara, Kensaku Kasuga, Yuko Saito, Shigeo Murayama, Akiyoshi Kakita, Hiroyasu Akatsu, Kouichi Ozaki, Shumpei Niida, Ryozo Kuwano, Takeshi Iwatsubo, Akihiro Nakaya, Takeshi Ikeuchi, the Alzheimer’s Disease Neuroimaging Initiative, the Japanese Alzheimer’s Disease Neuroimaging Initiative
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-20 (2024)
Abstract Background Polygenic effects have been proposed to account for some disease phenotypes; these effects are calculated as a polygenic risk score (PRS). This score is correlated with Alzheimer’s disease (AD)-related phenotypes, such as biomar
Externí odkaz:
https://doaj.org/article/57b43de8caa148689ec698144a567a93
Autor:
Masataka Kikuchi, Akinori Miyashita, Norikazu Hara, Kensaku Kasuga, Yuko Saito, Shigeo Murayama, Akiyoshi Kakita, Hiroyasu Akatsu, Kouichi Ozaki, Shumpei Niida, Ryozo Kuwano, Takeshi Iwatsubo, Akihiro Nakaya, Takeshi Ikeuchi, the Alzheimer’s Disease Neuroimaging Initiative, the Japanese Alzheimer’s Disease Neuroimaging Initiative
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-2 (2024)
Externí odkaz:
https://doaj.org/article/a23cc4e69d214992ac7e7d84d5eb743e
Autor:
Hisako Ichihara, Manabu Yamada, Mitsuyo Kohara, Hideki Hirakawa, Andrea Ghelfi, Takuro Tamura, Akihiro Nakaya, Yasukazu Nakamura, Sachiko Shirasawa, Samatchaya Yamashita, Yosuke Toda, Daijiro Harada, Tsunakazu Fujishiro, Akiko Komaki, Jeffrey A. Fawcett, Eiji Sugihara, Satoshi Tabata, Sachiko N. Isobe
Publikováno v:
BMC Plant Biology, Vol 23, Iss 1, Pp 1-10 (2023)
Abstract Background Plant genome information is fundamental to plant research and development. Along with the increase in the number of published plant genomes, there is a need for an efficient system to retrieve various kinds of genome-related infor
Externí odkaz:
https://doaj.org/article/948115dfd5d348bf8dfcfb634bdc59b6
Autor:
Jun-Ya Kaimori, Yamato Kikkawa, Daisuke Motooka, Tomoko Namba-Hamano, Ayako Takuwa, Atsuko Okazaki, Kaori Kobayashi, Arisa Tanigawa, Yuko Kotani, Yoshihiro Uno, Kazuto Yoshimi, Koki Hattori, Yuta Asahina, Sachio Kajimoto, Yohei Doi, Tatsufumi Oka, Yusuke Sakaguchi, Tomoji Mashimo, Kiyotoshi Sekiguchi, Akihiro Nakaya, Motoyoshi Nomizu, Yoshitaka Isaka
Publikováno v:
JCI Insight, Vol 7, Iss 23 (2022)
The LAMA5 gene encodes laminin α5, an indispensable component of glomerular basement membrane and other types of basement membrane. A homozygous pathological variant in LAMA5 is known to cause a systemic developmental syndrome including glomerulopat
Externí odkaz:
https://doaj.org/article/8f91ff89ee8c4aa2b7cf4c8996dd8af8
Autor:
Masataka Kikuchi, Kaori Kobayashi, Sakiko Itoh, Kensaku Kasuga, Akinori Miyashita, Takeshi Ikeuchi, Eiji Yumoto, Yuki Kosaka, Yasuto Fushimi, Toshihiro Takeda, Shirou Manabe, Satoshi Hattori, Akihiro Nakaya, Kenichi Kamijo, Yasushi Matsumura
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 5296-5308 (2022)
Mild cognitive impairment (MCI) is a high-risk condition for conversion to Alzheimer's disease (AD) dementia. However, individuals with MCI show heterogeneous patterns of pathology and conversion to AD dementia. Thus, detailed subtyping of MCI subjec
Externí odkaz:
https://doaj.org/article/4857f38a1bfc497499fd8b81e34488de
Autor:
Masataka Kikuchi, Kaori Kobayashi, Nao Nishida, Hiromi Sawai, Masaya Sugiyama, Masashi Mizokami, Katsushi Tokunaga, Akihiro Nakaya
Publikováno v:
Human Genome Variation, Vol 8, Iss 1, Pp 1-8 (2021)
Hepatitis B: Gene copy numbers associated with risk of infection The risk of contracting the hepatitis B virus may be linked to the number of copies of certain genes in an individual’s genome. A Japanese team led by Masataka Kikuchi, Osaka Universi
Externí odkaz:
https://doaj.org/article/7ac6c615142f41e4889441ba63445241
Autor:
Mitsuru Shinohara, Masataka Kikuchi, Miyuki Onishi‐Takeya, Yoshitaka Tashiro, Kaoru Suzuki, Yasuhiro Noda, Shuko Takeda, Masahiro Mukouzono, Seiichi Nagano, Akio Fukumori, Ryuichi Morishita, Akihiro Nakaya, Naoyuki Sato
Publikováno v:
FASEB BioAdvances, Vol 3, Iss 5, Pp 323-333 (2021)
Abstract Clinical studies have indicated that obesity and diabetes are associated with Alzheimer's disease (AD) and neurodegeneration. However, the mechanism by which obesity/diabetes and AD interact with each other and contribute to dementia remains
Externí odkaz:
https://doaj.org/article/14add0dde46f4712afdc24c83ff4af10
Autor:
Masataka Kikuchi, Norikazu Hara, Mai Hasegawa, Akinori Miyashita, Ryozo Kuwano, Takeshi Ikeuchi, Akihiro Nakaya
Publikováno v:
BMC Medical Genomics, Vol 12, Iss 1, Pp 1-16 (2019)
Abstract Background Genome-wide association studies (GWASs) have identified single-nucleotide polymorphisms (SNPs) that may be genetic factors underlying Alzheimer’s disease (AD). However, how these AD-associated SNPs (AD SNPs) contribute to the pa
Externí odkaz:
https://doaj.org/article/63c633cfa75f4b049a67fb92d1acc0df
Autor:
Tetsuo Ohnishi, Yuji Kiyama, Fumiko Arima‐Yoshida, Mitsutaka Kadota, Tomoe Ichikawa, Kazuyuki Yamada, Akiko Watanabe, Hisako Ohba, Kaori Tanaka, Akihiro Nakaya, Yasue Horiuchi, Yoshimi Iwayama, Manabu Toyoshima, Itone Ogawa, Chie Shimamoto‐Mitsuyama, Motoko Maekawa, Shabeesh Balan, Makoto Arai, Mitsuhiro Miyashita, Kazuya Toriumi, Yayoi Nozaki, Rumi Kurokawa, Kazuhiro Suzuki, Akane Yoshikawa, Tomoko Toyota, Toshihiko Hosoya, Hiroyuki Okuno, Haruhiko Bito, Masanari Itokawa, Shigehiro Kuraku, Toshiya Manabe, Takeo Yoshikawa
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 4, Pp n/a-n/a (2021)
Abstract Genomic defects with large effect size can help elucidate unknown pathologic architecture of mental disorders. We previously reported on a patient with schizophrenia and a balanced translocation between chromosomes 4 and 13 and found that th
Externí odkaz:
https://doaj.org/article/c3d643b8363c4222821faa0e5c5dffd8
Autor:
Qi Wang, Hiroshi Kurosaka, Masataka Kikuchi, Akihiro Nakaya, Paul A. Trainor, Takashi Yamashiro
Publikováno v:
Disease Models & Mechanisms, Vol 12, Iss 10 (2019)
Cleft palate (CP) is one of the most common congenital craniofacial anomalies in humans and can be caused by either single or multiple genetic and environmental factor(s). With respect to environmental factors, excessive intake of vitamin A during ea
Externí odkaz:
https://doaj.org/article/4701d9202f45446cb1ace69492effb80