Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Akihiro Morinaka"'
Autor:
Eijiro Umemura, Yoshihiko Kobayashi, Toru Nawa, Akihiro Morinaka, Masakatsu Shibasaki, Toshiaki Miyake, Shoichi Murakami, Yoshiaki Takahashi
Publikováno v:
The Journal of antibiotics. 71(2)
The emergence and spread of bacteria with resistance to antibacterial drugs in recent years is now considered a significant threat to global public health and the world economy.1, 2 In particular, the severe bacterial infections caused by methicillin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48035e2cbba29a902bf3245e6e098dfe
https://pubmed.ncbi.nlm.nih.gov/28655929
https://pubmed.ncbi.nlm.nih.gov/28655929
Autor:
Akihiro Morinaka, Yoshiaki Sakamaki, Kouji Kimura, Mototsugu Yamada, Wanchun Jin, Jun-ichi Wachino, Minoru Yonezawa, Yoshichika Arakawa, Hiromasa Kurosaki, Yoshihiro Yamaguchi, Anupriya Kumar
Publikováno v:
Antimicrobial agents and chemotherapy. 61(10)
The development of effective inhibitors that block extended-spectrum β-lactamases (ESBLs) and restore the action of β-lactams represents an effective strategy against ESBL-producing Enterobacteriaceae . We evaluated the inhibitory effects of the di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d05ad74be604d2767e130bebf29b800
https://pubmed.ncbi.nlm.nih.gov/28739781
https://pubmed.ncbi.nlm.nih.gov/28739781
Publikováno v:
Bioorganic & Medicinal Chemistry. 21:5841-5850
3-Alkyloxy and 3-amino phthalic acid derivatives were found to have metallo-β-lactamase inhibitory activity. Among them, 3-amino phthalic acid derivatives showed both potent activity against metallo-β-lactamase, IMP-1 inhibitory activity and a stro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca6ccbc75ee3d4ba5664180403c35539
https://doi.org/10.1016/j.bmc.2013.07.006
https://doi.org/10.1016/j.bmc.2013.07.006
Autor:
David M. Livermore, Takashi Ida, Akihiro Morinaka, Kazunori Maebashi, Russell Hope, Shazad Mushtaq
Publikováno v:
Journal of Antimicrobial Chemotherapy. 68:153-158
Objectives: ME1071 is a maleic acid that inhibits metallo-b-lactamases (MBLs). We examined its ability to potentiate different carbapenems against MBL-producing Enterobacteriaceae in relation to its inhibition kinetics. Methods: Enterobacteriaceae an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b102c155afc24bb87a72dfdf416a7925
https://doi.org/10.1093/jac/dks350
https://doi.org/10.1093/jac/dks350
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:5162-5165
4-Butyl-3-methylphthalic acid was recognized as a metallo-beta-lactamase inhibitor. The structure-activity relationship study of substituted phthalic acids afforded 3-phenylphthalic acid derivatives as potent IMP-1 inhibitors. On the other hand, 3-su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f012a1aaed6fbad9e2706380136da918
https://doi.org/10.1016/j.bmcl.2009.07.018
https://doi.org/10.1016/j.bmcl.2009.07.018
Autor:
Takashi Ida, Takeshi Furuuchi, Yuko Tsutsumi, Akihiro Morinaka, Seiichi Inamura, Yoshihiro Takayama, Keiko Yamada, Yoshiaki Sakamaki, Toshihiko Takata, Takao Abe, Shiro Sakakibara, Nakako Tsujii
Publikováno v:
Antimicrobial agents and chemotherapy. 60(5)
Gram-negative bacteria are evolving to produce β-lactamases of increasing diversity that challenge antimicrobial chemotherapy. OP0595 is a new diazabicyclooctane serine β-lactamase inhibitor which acts also as an antibiotic and as a β-lactamase-in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b7e331c7b9a37598770f0516ea5bb1c
https://pubmed.ncbi.nlm.nih.gov/26953205
https://pubmed.ncbi.nlm.nih.gov/26953205
Autor:
Yukiko Hiraiwa, Akihiro Morinaka, Takayoshi Fukushima, Takashi Watanabe, Mototsugu Yamada, Toshiaki Kudo, Jun Saito
Publikováno v:
Bioorganicmedicinal chemistry letters. 24(20)
3-(4-Hydroxypiperidine-1-yl) phthalic acid 1 shows potent inhibitory activity against metallo-β-lactamase, which is known to inactivate β-lactam antibiotics such as carbapenems. Here, the structure of co-crystals of the metallo-β-lactamase IMP-1 a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0ed1ff1c98267ec83f3fb1109824c4c
https://pubmed.ncbi.nlm.nih.gov/25246278
https://pubmed.ncbi.nlm.nih.gov/25246278
Publikováno v:
Journal of the Society of Naval Architects of Japan. 1999:91-98
In the old days, flying boats are widely used because wide sea surface could be utilized as run ways without maintenance.But today, utilization of flying boats is only for the rescue in sea disasters. Considering the small land space like Japan, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed59dfde21953f8eac0c69eee372ff57
https://doi.org/10.2534/jjasnaoe1968.1999.91
https://doi.org/10.2534/jjasnaoe1968.1999.91
Autor:
Akihiro Morinaka, Yuko Tsutsumi, Mototsugu Yamada, Kenji Suzuki, Takashi Watanabe, Takao Abe, Takeshi Furuuchi, Seiichi Inamura, Yoshiaki Sakamaki, Nakako Mitsuhashi, Takashi Ida, Livermore, David M., Morinaka, Akihiro, Tsutsumi, Yuko, Yamada, Mototsugu, Suzuki, Kenji, Watanabe, Takashi, Abe, Takao, Furuuchi, Takeshi, Inamura, Seiichi
Publikováno v:
Journal of Antimicrobial Chemotherapy (JAC); Oct2015, Vol. 70 Issue 10, p2779-2786, 8p