Preclinical bioequivalence study of E.coli-derived rhBMP-2/β-TCP and autogenous bone in a canine guided-bone regeneration model

Autor: Toshitaka Oohashi, Yukie Tanaka, Kei Ishibashi, Taishi Komori, Emilio Satoshi Hara, Takuo Kuboki, Aya Kimura-Ono, Shuji Nosho, Akihiro Mikai, Ikue Tosa, Mitsuaki Ono

Publikováno v: Journal of Prosthodontic Research. 66:124-130

Purpose Bone morphogenetic protein (BMP)-2 is a potent growth factor that is widely used in the orthopedic and dental fields for bone regeneration.However, recombinant human BMP-2 (rhBMP-2) products have not been legally approved in Japan. Recently,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a13a5819f194bea41cb30f54579ab93c
https://doi.org/10.2186/jpr.jpr_d_20_00226

Suppression of Bone Necrosis around Tooth Extraction Socket in a MRONJ-like Mouse Model by E-rhBMP-2 Containing Artificial Bone Graft Administration

Autor: Aya Ono-Kimura, Yukie Tanaka, Mitsuaki Ono, Akihiro Mikai, Ikue Tosa, Anh Tuan Dang, Emilio Satoshi Hara, Kei Ishibashi, Kumiko Nawachi, Takuo Kuboki, Kyaw Thu Aung, Toshitaka Oohashi

Publikováno v: International Journal of Molecular Sciences; Volume 22; Issue 23; Pages: 12823
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 12823, p 12823 (2021)

Medication-related osteonecrosis of the jaw (MRONJ) is related to impaired bone healing conditions in the maxillomandibular bone region as a complication of bisphosphonate intake. Although there are several hypotheses for the onset of MRONJ symptoms,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2826752484acdfb32ad9ce9434bc0c32
https://doi.org/10.3390/ijms222312823