Zn Complex of Diaminedithiol Tetradentate Ligand as a Stable Precursor for 99mTc-Labeled Compounds

Autor: Shinobu Oshikiri, Tomoya Uehara, Hiroyuki Suzuki, Miho Koike-Satake, Akihiro Hino, Yasushi Arano

Publikováno v: Molecules, Vol 25, Iss 2, p 254 (2020)

The diaminedithiol (N2S2) tetradentate ligand constitutes a useful chelating molecule for preparing 99mTc-labeled compounds of high in vivo stability in high radiochemical yields. However, since the thiol groups in the N2S2 ligand are easy to be oxid

Externí odkaz: https://doaj.org/article/997f39faddab4e31b8b8442e1097b13f

90Y-Labeled Anti-ROBO1 Monoclonal Antibody Exhibits Antitumor Activity against Small Cell Lung Cancer Xenografts.

Autor: Kentaro Fujiwara, Keitaro Koyama, Kosuke Suga, Masako Ikemura, Yasutaka Saito, Akihiro Hino, Hiroko Iwanari, Osamu Kusano-Arai, Kenichi Mitsui, Hiroyuki Kasahara, Masashi Fukayama, Tatsuhiko Kodama, Takao Hamakubo, Toshimitsu Momose

Publikováno v: PLoS ONE, Vol 10, Iss 5, p e0125468 (2015)

ROBO1 is a membrane protein that contributes to tumor metastasis and angiogenesis. We previously reported that 90Y-labeled anti-ROBO1 monoclonal antibody (90Y-anti-ROBO1 IgG) showed an antitumor effect against ROBO1-positive tumors. In this study, we

Externí odkaz: https://doaj.org/article/3809186e4cb74335a57fd7dd6f1ab7a5

Improvement of Efficiency in Bidirectional DC-DC Converter with Dual Active Bridge Using GaN-HEMT

Autor: Ryuji Yamada, Akihiro Hino, Keiji Wada

Publikováno v: IEEJ Journal of Industry Applications. 12:264-272

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad063adca7593c3ac0cd85b624ac4c5d
https://doi.org/10.1541/ieejjia.22006373

Preclinical Characterization of the Radioimmunoconjugate 111In or 90Y-FF-21101 Against a P-Cadherin–Expressing Tumor in a Mouse Xenograft Model and a Nonhuman Primate

Autor: Masahiko Tokura, Akihiro Hino, Yuichi Funase, Masamichi Kajita, Michi Kitano, Shinobu Oshikiri, Yasutaka Saito, Tomoya Uehara, Eri Nakamura

Publikováno v: Journal of Nuclear Medicine

Visual Abstract
P-cadherin is overexpressed in various cancers and can be a target for radioimmunotherapy. We investigated the preclinical pharmacokinetics and pharmacology of FF-21101, an 111In- or 90Y-conjugated monoclonal antibody against P-c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad95e2f450e99c613d3fee4019e3dfbc
https://doi.org/10.2967/jnumed.120.245837

Cardiovascular Prognosis in Drug-Resistant Hypertension Stratified by 24-Hour Ambulatory Blood Pressure: The JAMP Study

Autor: Kazuomi Kario, Satoshi Hoshide, Keisuke Narita, Yukie Okawara, Hiroshi Kanegae, Kenji Aoki, Hajime Kihara, Toshiro Koga, Tomoaki Nakata, Kenji Oku, Yasufumi Matsuoka, Hiroaki Omori, Masafumi Nishizawa, Yasuo Tanno, Yoko Fukase, Koki Omi, Jun Takahashi, Hiroyuki Mizuno, Michiya Saito, Junichi Yatabe, Kazuo Eguchi, Kiyoshi Iwashita, Maki Kumada, Gaku Oki, Tomoyuki Kabutoya, Yukihiro Hojo, Masaru Ichida, Shizukiyo Ishikawa, Takahiro Komori, Yoshio Matsui, Masatoshi Matsumoto, Shoichiro Nagasaka, Masahiro Nakano, Yoshioki Nishimura, Kenta Okada, Kazuyuki Shimada, Masahisa Shimpo, Nozomu Takahashi, Hideyuki Uno, Joji Ishikawa, Toshio Kuroda, Nobutsune Hirahara, Yuta Kemi, Hisashi Yoshioka, Sakuo Hoshi, Atsuhi Mizuno, Kunihiko Ohno, Osamu Okazaki, Tsunehiro Saito, Tetsu Tanaka, Kazuo Yamashiro, Tatsuyuki Yamauchi, Shisei Yo, Shigeru Yomogita, Sayaka Hikita, Yasuhiro Kawase, Yoshifumi Nojiri, Yukihiro Sato, Kiyoshi Uchiba, Motoyuki Ishiguro, Atsushi Taguchi, Kazumasa Iida, Tatsuya Takemoto, Katsuyuki Tone, Hideyasu Abe, Yasuhisa Abe, Masami Hasegawa, Tomohiro Katsuya, Yoshiharu Okada, Shinichiro Tanaka, Genyo Tanke, Takeshi Takami, Jun Michiura, Masahiko Shiotani, Tomohiro Aoki, Koichi Ogura, Yuzuru Kawamura, Shigekiyo Nakanishi, Nobuo Sasaki, Toshiyuki Takahashi, Akihisa Fujii, Eiichiro Tanaka, Hiroyuki Katayama, Motoki Fukutomi, Kosuke Miyoshi, Hiroaki Naito, Sawa Yokota, Kazumasa Nakamura, Tetsu Yokota, Shinsuke Takasugi, Shuichiro Fujita, Yumiko Fujita, Hitoshi Kaneko, Takeshi Fujiwara, Wataru Kitamura, Yuhei Anan, Tomohiro Deguchi, Yuki Imaizumi, Jun Miyagi, Takahiro Tsuji, Yasuhiro Uchiwa, Shin Ueda, Takeya Yamaguchi, Tetsuro Yoshida, Ryo Yoshinaga, Kosuke Maeda, Kotaro Kunitomo, Kyousei Soda, Hirotoshi Baba, Keisuke Yonezu, Akihiro Hino, Genta Miura, Tomoko Nakamura, Munetoshi Kuroki, Fumihiko Omori, Toshiaki Hidaka, Takanori Hidaka, Yuichiro Yano, Yoshimasa Kanemaru, Michitaka Kitani, Masahiro Koga, Hirohide Kubo, Masachika Kuwabara, Junichi Miyata, Masahiko Nagata, Koji Sasaki, Noboru Tamaki, Hiroyasu Tasaka, Naoto Yokota, Takahiro Miyata, Eiyu Katsuren, Norifumi Kudeken, Noriharu Yagi

Publikováno v: Hypertension (Dallas, Tex. : 1979). 78(6)

Resistant hypertension is an important cardiovascular risk factor. This analysis of the JAMP study (Japan Ambulatory Blood Pressure Monitoring Prospective) data investigated the effects of uncontrolled resistant hypertension diagnosed using ambulator

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89451018ff49332da6401353c066ea8f
https://pubmed.ncbi.nlm.nih.gov/34719242