Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Akihiro Furukawa"'
Publikováno v:
Journal of Advanced Mechanical Design, Systems, and Manufacturing, Vol 6, Iss 1, Pp 189-197 (2012)
The residual stress at the thread root of a bolt is one of the major factors influencing the fatigue strength. Some hypotheses have been proposed to predict the fatigue strength from the local stress on the thread root. However, these have not yet be
Externí odkaz:
https://doaj.org/article/63602e3dc43e474aa95ab6589406353a
Autor:
Akihiro FURUKAWA, Masaya HAGIWARA
Publikováno v:
Mechanical Engineering Journal, Vol 2, Iss 4, Pp 14-00293-14-00293 (2015)
Yoshimoto had been presented a hypothesis concerning the fatigue strength of a bolt in bolt/nut assembly using Ishibashi's hypothesis on the relationship between the fatigue notch factor and the local stress distribution on the first thread root of a
Externí odkaz:
https://doaj.org/article/0490f762ddb8408fbc04cc0bf194f601
Publikováno v:
Journal of the Japan Society for Precision Engineering. 87:329-332
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b740936aaf9293ade85266a21eb278b
https://doi.org/10.2493/jjspe.87.329
https://doi.org/10.2493/jjspe.87.329
Publikováno v:
The Proceedings of Mechanical Engineering Congress, Japan. 2021:S112-15
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32178cdf502c0e5e9a20e379e9fb58b4
https://doi.org/10.1299/jsmemecj.2021.s112-15
https://doi.org/10.1299/jsmemecj.2021.s112-15
Drug‐Like Properties in Macrocycles above MW 1000: Backbone Rigidity versus Side‐Chain Lipophilicity
Autor:
R. Scott Lokey, Victoria G. Klein, Daigo Asano, Quinn Edmondson, Cameron R. Pye, Akihiro Furukawa, Joshua Schwochert, Satoshi Ono, Okimasa Okada, Alexandra C Turmon
Publikováno v:
Angew Chem Int Ed Engl
Large, macrocyclic peptides can achieve surprisingly high membrane permeability, although the properties that govern permeability in this chemical space are only beginning to come into focus. We generated two libraries of cyclic decapeptides with sta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1093734f1141e2862b09aace99f0bac8
https://doi.org/10.1002/anie.202004550
https://doi.org/10.1002/anie.202004550
Autor:
Akihiro Furukawa, Chad E. Townsend, Cameron R. Pye, R. Scott Lokey, Joshua Schwochert, Quinn Edmondson
Publikováno v:
Bioorganic & Medicinal Chemistry. 26:1232-1238
Cyclic peptides are of great interest as therapeutic compounds due to their potential for specificity and intracellular activity, but specific compounds can be difficult to identify from large libraries without resorting to molecular encoding techniq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::793dd88daddc16880417b954ef8d6c5f
https://doi.org/10.1016/j.bmc.2018.01.027
https://doi.org/10.1016/j.bmc.2018.01.027
Autor:
Alan M. Mathiowetz, Cameron R. Pye, Spiros Liras, R. Scott Lokey, Akihiro Furukawa, Chad E. Townsend, Lyns Etienne, Yongtong Lao, Terra D. Haddad, Chris Limberakis, David Price, Joshua Schwochert, William M. Hewitt
Publikováno v:
Journal of Medicinal Chemistry. 60:1665-1672
Macrocyclic peptides are considered large enough to inhibit “undruggable” targets, but the design of passively cell-permeable molecules in this space remains a challenge due to the poorly understood role of molecular size on passive membrane perm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a18857e0d51e3ed2eea2a90eb515a7b
https://doi.org/10.1021/acs.jmedchem.6b01483
https://doi.org/10.1021/acs.jmedchem.6b01483
Publikováno v:
The Proceedings of Mechanical Engineering Congress, Japan. 2020:S11206
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::428ef43c01e97bedab7c862a90b167d8
https://doi.org/10.1299/jsmemecj.2020.s11206
https://doi.org/10.1299/jsmemecj.2020.s11206
Autor:
Masaya Hagiwara, Akihiro Furukawa
Publikováno v:
Mechanical Engineering Journal, Vol 2, Iss 4, Pp 14-00293-14-00293 (2015)
Yoshimoto had been presented a hypothesis concerning the fatigue strength of a bolt in bolt/nut assembly using Ishibashi's hypothesis on the relationship between the fatigue notch factor and the local stress distribution on the first thread root of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7bf34885b32771a88c1927850f3df59
https://doi.org/10.1299/mej.14-00293
https://doi.org/10.1299/mej.14-00293
Publikováno v:
The Proceedings of Mechanical Engineering Congress, Japan. 2019:S11302
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d137df0d47d174fc329063f483cf250f
https://doi.org/10.1299/jsmemecj.2019.s11302
https://doi.org/10.1299/jsmemecj.2019.s11302