Zobrazeno 1 - 10
of 180
pro vyhledávání: '"Akihiro Fujimoto"'
Autor:
Kugui Yoshida-Tanaka, Mihoko Shimada, Yoshiko Honda, Akihiro Fujimoto, Katsushi Tokunaga, Makoto Honda, Taku Miyagawa
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Narcolepsy type 1 (NT1) is caused by a loss of hypothalamic orexin-producing cells, and autoreactive CD4+ and CD8+ T cells have been suggested to play a role in the autoimmune mechanism. Although NT1 showed a strong association with human le
Externí odkaz:
https://doaj.org/article/f19c9790267044e7a445e0b068fb32ca
Publikováno v:
Human Genomics, Vol 17, Iss 1, Pp 1-16 (2023)
Abstract Background Long-read sequencing technologies have the potential to overcome the limitations of short reads and provide a comprehensive picture of the human genome. However, the characterization of repetitive sequences by reconstructing genom
Externí odkaz:
https://doaj.org/article/3cd5833a470a4a6c8e529aa90031c810
Autor:
Tomonori Kawasaki, Tomoaki Tashima, Chisako Muramatsu, Akihiro Fujimoto, Yoko Usami, Hitomi Kodama, Jiro Ichikawa, Hirokazu Nagai, Kiyomi Taniyama
Publikováno v:
Cancer Reports, Vol 6, Iss 2, Pp n/a-n/a (2023)
Abstract Background Herein, for the first time, we present a case with mixed invasive micropapillary and neuroendocrine mammary neoplasm. Case The patient, a 65‐year‐old postmenopausal woman, had become aware of a tumor in her right breast 11 mon
Externí odkaz:
https://doaj.org/article/30e49cd2b72444b6ba3b08a3e4dbed1d
Autor:
Shinichi Mizuno, Rui Yamaguchi, Takanori Hasegawa, Shuto Hayashi, Masashi Fujita, Fan Zhang, Youngil Koh, Su-Yeon Lee, Sung-Soo Yoon, Eigo Shimizu, Mitsuhiro Komura, Akihiro Fujimoto, Momoko Nagai, Mamoru Kato, Han Liang, Satoru Miyano, Zemin Zhang, Hidewaki Nakagawa, Seiya Imoto
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Immune reactions in the tumor microenvironment are an important hallmark of cancer, and emerging immune therapies have been proven effective against several types of cancers. To investigate cancer genome-immune interactions and the role of i
Externí odkaz:
https://doaj.org/article/351129f51da84158b681c55273869ced
Autor:
Hiroki Kiyose, Hidewaki Nakagawa, Atsushi Ono, Hiroshi Aikata, Masaki Ueno, Shinya Hayami, Hiroki Yamaue, Kazuaki Chayama, Mihoko Shimada, Jing Hao Wong, Akihiro Fujimoto
Publikováno v:
PLoS Genetics, Vol 18, Iss 8, p e1010342 (2022)
Genes generate transcripts of various functions by alternative splicing. However, in most transcriptome studies, short-reads sequencing technologies (next-generation sequencers) have been used, leaving full-length transcripts unobserved directly. Alt
Externí odkaz:
https://doaj.org/article/906cb0a5ce6f4d62a7cb5f7c0c99e0ce
Autor:
Akihiro Fujimoto, Jing Hao Wong, Yukiko Yoshii, Shintaro Akiyama, Azusa Tanaka, Hitomi Yagi, Daichi Shigemizu, Hidewaki Nakagawa, Masashi Mizokami, Mihoko Shimada
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-15 (2021)
Abstract Background Identification of germline variation and somatic mutations is a major issue in human genetics. However, due to the limitations of DNA sequencing technologies and computational algorithms, our understanding of genetic variation and
Externí odkaz:
https://doaj.org/article/bc8e6c29eecc44cf9b422cc28d4fda86
Autor:
Nao Nishida, Jun Ohashi, Goki Suda, Takehiro Chiyoda, Nobuharu Tamaki, Takahiro Tomiyama, Sachiko Ogasawara, Masaya Sugiyama, Yosuke Kawai, Seik-Soon Khor, Masao Nagasaki, Akihiro Fujimoto, Takayo Tsuchiura, Miyuki Ishikawa, Koichi Matsuda, Hirohisa Yano, Tomoharu Yoshizumi, Namiki Izumi, Kiyoshi Hasegawa, Naoya Sakamoto, Masashi Mizokami, Katsushi Tokunaga
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 5, p 4761 (2023)
The development of liver cancer in patients with hepatitis B is a major problem, and several models have been reported to predict the development of liver cancer. However, no predictive model involving human genetic factors has been reported to date.
Externí odkaz:
https://doaj.org/article/2ef071f4f95b4c1aaaf7374f5a3d1ba7
Autor:
Masaki Tanaka, Shinji Naganawa, Norio Ozaki, Akihiro Fujimoto, Ippei Okada, Kunihiro Iwamoto, Seiko Miyata, Manabu Amano, Nao Matsuyama, Toshiaki Taoka
Publikováno v:
BMJ Open, Vol 11, Iss 11 (2021)
Introduction Bidirectional associations have been reported between sleep disturbance and both cognitive impairment, including Alzheimer’s disease and amyloid beta-peptide (Aβ) accumulation. These relationships can be explained by the glymphatic sy
Externí odkaz:
https://doaj.org/article/75b46484d0d542cc906d4d7aad2475d2
Autor:
Jing Hao Wong, Daichi Shigemizu, Yukiko Yoshii, Shintaro Akiyama, Azusa Tanaka, Hidewaki Nakagawa, Shu Narumiya, Akihiro Fujimoto
Publikováno v:
Genome Medicine, Vol 11, Iss 1, Pp 1-15 (2019)
Abstract Background Next-generation sequencing has allowed for the identification of different genetic variations, which are known to contribute to diseases. Of these, insertions and deletions are the second most abundant type of variations in the ge
Externí odkaz:
https://doaj.org/article/6e6ded06d44e426c815c8e48ffe41fe4
Autor:
Azusa Tanaka, Yasuhiro Ishitsuka, Hiroki Ohta, Akihiro Fujimoto, Jun-Ichirou Yasunaga, Masao Matsuoka
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 11, p e1008422 (2020)
The huge amount of data acquired by high-throughput sequencing requires data reduction for effective analysis. Here we give a clustering algorithm for genome-wide open chromatin data using a new data reduction method. This method regards the genome a
Externí odkaz:
https://doaj.org/article/4205b08643c64b7883c1718788773ac7