Zobrazeno 1 - 10
of 250
pro vyhledávání: '"Akihiro, Takano"'
Autor:
Ryosuke Arakawa, Akihiro Takano, Sangram Nag, Zhisheng Jia, Nahid Amini, Kevin P. Maresca, Lei Zhang, Edmund J. Keliher, Christopher R. Butler, Justin R. Piro, Tarek A. Samad, Deborah Smith, Deane Nason, Steve O’Neil, Patrick Trapa, Kari R. Fonseca, John Litchfield, Timothy McCarthy, Richard E. Carson, Christer Halldin
Publikováno v:
EJNMMI Research, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract Background Monoacylglycerol lipase (MAGL) is a key serine hydrolase which terminates endocannabinoid signaling and regulates arachidonic acid driven inflammatory responses within the central nervous system. To develop [11C]PF-06809247 into a
Externí odkaz:
https://doaj.org/article/0b2d2f0ac72047df80a3f5d00a8935c1
Publikováno v:
Neuropsychopharmacology Reports, Vol 40, Iss 2, Pp 114-121 (2020)
Abstract Positron emission tomography (PET) is a non‐invasive imaging method to measure the molecule in vivo. PET imaging can evaluate the central nervous system drugs as target engagement in the human brain. For antipsychotic drugs, adequate dopam
Externí odkaz:
https://doaj.org/article/572320dcf5b84a2e9c3fc24c7a437004
Autor:
Magnus Schou, Pär Ewing, Zsolt Cselenyi, Markus Fridén, Akihiro Takano, Christer Halldin, Lars Farde
Publikováno v:
EJNMMI Research, Vol 9, Iss 1, Pp 1-10 (2019)
Abstract Background Positron emission tomography (PET) is a non-invasive molecular imaging technique that traces the distribution of radiolabeled molecules in experimental animals and human subjects. We hypothesized that PET could be used to visualiz
Externí odkaz:
https://doaj.org/article/b5670c54e71a4432942d0c3a22be322f
Publikováno v:
Translational Psychiatry, Vol 8, Iss 1, Pp 1-10 (2018)
Abstract The serotonin (5-HT) system plays an important role in the pathophysiology and treatment of several major psychiatric disorders. Currently, no suitable positron emission tomography (PET) imaging paradigm is available to assess 5-HT release i
Externí odkaz:
https://doaj.org/article/a32f15af097a4eb3b331bdbbcd6257eb
Autor:
Ryosuke Arakawa, Per Stenkrona, Akihiro Takano, Sangram Nag, Rafael S. Maior, Christer Halldin
Publikováno v:
EJNMMI Research, Vol 7, Iss 1, Pp 1-7 (2017)
Abstract Background [11C]-l-deprenyl-D2 is a positron emission tomography (PET) radioligand for measurement of the monoamine oxidase B (MAO-B) activity in vivo brain. The estimation of the test-retest reproducibility is important for accurate interpr
Externí odkaz:
https://doaj.org/article/3baa5c1af8384fa88285f083c1390b49
Autor:
Yuichi Wakabayashi, Per Stenkrona, Ryosuke Arakawa, Xuefeng Yan, Maia G. Van Buskirk, Madeline D. Jenkins, Jose A. Montero Santamaria, Kevin P. Maresca, Akihiro Takano, Jeih-San Liow, Thomas A. Chappie, Andrea Varrone, Sangram Nag, Lei Zhang, Zoë A. Hughes, Christopher J. Schmidt, Shawn D. Doran, Andrew Mannes, Paolo Zanotti-Fregonara, Maarten Ooms, Cheryl L. Morse, Sami S. Zoghbi, Christer Halldin, Victor W. Pike, Robert B. Innis
Publikováno v:
Journal of Nuclear Medicine. 63:1919-1924
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::61c7d547cbcb5109418140c2b1e19428
https://doi.org/10.2967/jnumed.122.263838
https://doi.org/10.2967/jnumed.122.263838
Autor:
Darren A.E. Cross, Zack Cheng, Lars Farde, Paul D. Smith, James W.T. Yates, Richard A. Ward, M. Raymond V. Finlay, Natasha A. Karp, Albert D. Windhorst, Mohammad Mahdi Moein, Ana Vazquez-Romero, Evgeny Revunov, Jonas Malmquist, Mikhail Kondrashov, Ryosuke Arakawa, Akihiro Takano, Aaron Smith, Joanne Wilson, Annika Janefeldt, Lin Zhang, James Atkinson, Peter Barton, Gareth Maglennon, Don X. Nguyen, Minghui Zhao, Sally J. Adua, Katarina Varnäs, Richard Goodwin, Magnus Schou, Gail L. Wrigley, Yumei Yan, Nicole Strittmatter, Peter Johnström, Kan Chen, Nicola Colclough
Purpose:Osimertinib is a potent and selective EGFR tyrosine kinase inhibitor (EGFR-TKI) of both sensitizing and T790M resistance mutations. To treat metastatic brain disease, blood–brain barrier (BBB) permeability is considered desirable for increa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e99bce52b9e8d79380691bf89afec19
https://doi.org/10.1158/1078-0432.c.6528456
https://doi.org/10.1158/1078-0432.c.6528456
Autor:
Darren A.E. Cross, Zack Cheng, Lars Farde, Paul D. Smith, James W.T. Yates, Richard A. Ward, M. Raymond V. Finlay, Natasha A. Karp, Albert D. Windhorst, Mohammad Mahdi Moein, Ana Vazquez-Romero, Evgeny Revunov, Jonas Malmquist, Mikhail Kondrashov, Ryosuke Arakawa, Akihiro Takano, Aaron Smith, Joanne Wilson, Annika Janefeldt, Lin Zhang, James Atkinson, Peter Barton, Gareth Maglennon, Don X. Nguyen, Minghui Zhao, Sally J. Adua, Katarina Varnäs, Richard Goodwin, Magnus Schou, Gail L. Wrigley, Yumei Yan, Nicole Strittmatter, Peter Johnström, Kan Chen, Nicola Colclough
Supplementary Figure S1 - Structure and position of label for compounds assessed for BBB penetrance in non human primates (NHP). Majority of compounds were labelled with carbon-11 except afatinib which was labelled with fluorine-18. (*) Indicates pos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f25e8e82af5345d6a7e68e8c3a46ea5
https://doi.org/10.1158/1078-0432.22473252
https://doi.org/10.1158/1078-0432.22473252
Autor:
Darren A.E. Cross, Zack Cheng, Lars Farde, Paul D. Smith, James W.T. Yates, Richard A. Ward, M. Raymond V. Finlay, Natasha A. Karp, Albert D. Windhorst, Mohammad Mahdi Moein, Ana Vazquez-Romero, Evgeny Revunov, Jonas Malmquist, Mikhail Kondrashov, Ryosuke Arakawa, Akihiro Takano, Aaron Smith, Joanne Wilson, Annika Janefeldt, Lin Zhang, James Atkinson, Peter Barton, Gareth Maglennon, Don X. Nguyen, Minghui Zhao, Sally J. Adua, Katarina Varnäs, Richard Goodwin, Magnus Schou, Gail L. Wrigley, Yumei Yan, Nicole Strittmatter, Peter Johnström, Kan Chen, Nicola Colclough
Supplementary Data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be6d4e8315f07cd887541e19008edbfb
https://doi.org/10.1158/1078-0432.22473249.v1
https://doi.org/10.1158/1078-0432.22473249.v1
Autor:
Akihiro Takano
Publikováno v:
Journal of Knot Theory and Its Ramifications. 31
In this paper, we compute the twisted Alexander invariant of the braid group associated with the Tong–Yang–Ma representation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e50023bec51148e2a3e41159813fbebb
https://doi.org/10.1142/s0218216522500651
https://doi.org/10.1142/s0218216522500651