Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Akihiro, Sugawara"'
Autor:
Fumito Sato, Terutaka Sonohara, Shunta Fujiki, Akihiro Sugawara, Yohei Morishita, Taro Ozaki, Teigo Asai
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 20, Iss 1, Pp 714-720 (2024)
Labdane-related diterpenoids (LRDs) in fungi are a pharmaceutically important, but underexplored family of natural products. In the biosynthesis of fungal LRDs, bifunctional terpene cyclases (TCs) consisting of αβγ domains are generally used to sy
Externí odkaz:
https://doaj.org/article/d5b0f62216a44a9082bac53facc51ccc
Autor:
Yoshihide Suzuki, Keisuke Ichinohe, Akihiro Sugawara, Shinya Kida, Shinya Murase, Jing Zhang, Osamu Yamada, Toshio Hattori, Yoshiteru Oshima, Haruhisa Kikuchi
Publikováno v:
Frontiers in Chemistry, Vol 9 (2021)
Cancer immunotherapy involves the use of the immune system for cancer treatment. Recently, immune checkpoint-blocking antibodies have become integral for the treatment of some cancers. However, small molecules exhibit advantages over monoclonal antib
Externí odkaz:
https://doaj.org/article/5446e2a977fb434dabf63311a85d4f08
Autor:
Sho Furumura, Taro Ozaki, Akihiro Sugawara, Yohei Morishita, Kento Tsukada, Tatsuya Ikuta, Asuka Inoue, Teigo Asai
Publikováno v:
Journal of Natural Products. 86:398-405
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c58ec186bb1d60f51ea9626508210d2
https://doi.org/10.1021/acs.jnatprod.2c01027
https://doi.org/10.1021/acs.jnatprod.2c01027
Publikováno v:
Organic Letters. 24:3504-3509
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3811312b1ce6160af9e852db365f327a
https://doi.org/10.1021/acs.orglett.2c01172
https://doi.org/10.1021/acs.orglett.2c01172
Autor:
Hitomi Sasaki, Yuzuru Kubohara, Hirotaka Ishigaki, Katsunori Takahashi, Hiromi Eguchi, Akihiro Sugawara, Yoshiteru Oshima, Haruhisa Kikuchi
Publikováno v:
Molecules, Vol 25, Iss 12, p 2895 (2020)
We report a protoilludane-type sesquiterpene, mucoroidiol, and a geranylated bicyclogermacranol, firmibasiol, isolated from Dictyostelium cellular slime molds. The methanol extracts of the fruiting bodies of cellular slime molds were separated by chr
Externí odkaz:
https://doaj.org/article/6ac83fdd4d704b729655b20661467912
Herein, we develop glycidyl silanes to facilitate highly regioselective hydrosilylation of internal propargyl alcohols, the products of which can in turn be converted to synthetically useful fluorosilanes for further chemical transfor-mations under m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15d752ed614fc2d8556ae41093173023
https://doi.org/10.26434/chemrxiv-2022-3dsm2
https://doi.org/10.26434/chemrxiv-2022-3dsm2
Autor:
Peter D. Kwong, Brennan P. Carman, Andrés Finzi, Dongjun Peng, Walther Mothes, Daniel S. Terry, Joseph Sodroski, Amos B. Smith, Baoshan Zhang, Cameron F. Abrams, Jason Gorman, Michael Farzan, Nick Reichard, Maolin Lu, Utz Ermel, Tongqing Zhou, Luis R. Castillo-Menendez, Akihiro Sugawara, Kevin Wang, Jonathan R. Grover, James Arthos, Scott C. Blanchard, James B. Munro, Michael Chambers, Adrian B. McDermott, Ivana Nikić-Spiegel, Edward A. Lemke, Xiaochu Ma, Matthew R. Gardner, Nirmin Alsahafi
Publikováno v:
Nature
The HIV-1 envelope glycoprotein (Env) trimer mediates cell entry and is conformationally dynamic1-8. Imaging by single-molecule fluorescence resonance energy transfer (smFRET) has revealed that, on the surface of intact virions, mature pre-fusion Env
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f66785f30afa4ad33e5181894467368c
https://doi.org/10.1038/s41586-019-1101-y
https://doi.org/10.1038/s41586-019-1101-y
Autor:
Akihiro Sugawara, Takeshi Yamada, Aoi Kimishima, Takanori Matsumaru, Hirokazu Takada, Toshiaki Sunazuka, Tomoyasu Hirose, Masaki Toda, Toru Kojima
Publikováno v:
Organic letters. 23(5)
Regio- and stereoselective hydrostannylation of alkyl ethynyl ethers generates alkenyl ethers, which are useful building blocks in organic synthesis. This efficient synthetic method, however, is limited. Here, we report not only an efficient method f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5df0ac12aad9baee242eb22e6a256162
https://pubmed.ncbi.nlm.nih.gov/33591766
https://pubmed.ncbi.nlm.nih.gov/33591766
Autor:
Young Do Kwon, Judith M LaLonde, Yongping Yang, Mark A Elban, Akihiro Sugawara, Joel R Courter, David M Jones, Amos B Smith, Asim K Debnath, Peter D Kwong
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e85940 (2014)
Efforts to develop therapeutic agents that inhibit HIV-1 entry have led to the identification of several small molecule leads. One of the most promising is the NBD series, which binds within a conserved gp120 cavity and possesses para-halogen substit
Externí odkaz:
https://doaj.org/article/e73d4da82ce24696811bc79c63f7a780
Autor:
Hirotaka Ishigaki, Haruhisa Kikuchi, Hiromi Eguchi, Yoshiteru Oshima, Akihiro Sugawara, Yuzuru Kubohara, Katsunori Takahashi, Hitomi Sasaki
Publikováno v:
Molecules, Vol 25, Iss 2895, p 2895 (2020)
Molecules
Volume 25
Issue 12
Molecules
Volume 25
Issue 12
We report a protoilludane-type sesquiterpene, mucoroidiol, and a geranylated bicyclogermacranol, firmibasiol, isolated from Dictyostelium cellular slime molds. The methanol extracts of the fruiting bodies of cellular slime molds were separated by chr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::728034f743f71ed8a6a664459aec8748
https://www.mdpi.com/1420-3049/25/12/2895
https://www.mdpi.com/1420-3049/25/12/2895