Výsledky vyhledávání - "Akihiro, Honda"

Akademický článek

Different Coactivator Recruitment to Human PPARα/δ/γ Ligand-Binding Domains by Eight PPAR Agonists to Treat Nonalcoholic Fatty Liver Disease

Autor: Shotaro Kamata, Akihiro Honda, Nonoka Kashiwagi, Ayumi Shimamura, Sayaka Yashiro, Yuna Komori, Aoi Hosoda, Noriyuki Akahoshi, Isao Ishii

Publikováno v: Biomedicines, Vol 12, Iss 3, p 624 (2024)

Three peroxisome proliferator-activated receptor subtypes, PPARα, PPAR(ß/)δ, and PPARγ, exert ligand-dependent transcriptional control in concert with retinoid X receptors (RXRs) on various gene sets harboring PPAR response elements (PPREs) in th

Externí odkaz: https://doaj.org/article/e0100f18dab94f4cb159c0659b44680b

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Akademický článek

Current Clinical Trial Status and Future Prospects of PPAR-Targeted Drugs for Treating Nonalcoholic Fatty Liver Disease

Autor: Shotaro Kamata, Akihiro Honda, Isao Ishii

Publikováno v: Biomolecules, Vol 13, Iss 8, p 1264 (2023)

The number of patients with nonalcoholic fatty liver disease (NAFLD)/nonalcoholic steatohepatitis (NASH) is increasing globally and is raising serious concerns regarding the increasing medical and economic burden incurred for their treatment. The pro

Externí odkaz: https://doaj.org/article/1c08f3f259e84fa99d6471d3aa221987

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Akademický článek

Functional and Structural Insights into the Human PPARα/δ/γ Targeting Preferences of Anti-NASH Investigational Drugs, Lanifibranor, Seladelpar, and Elafibranor

Autor: Shotaro Kamata, Akihiro Honda, Ryo Ishikawa, Makoto Akahane, Ayane Fujita, Chihiro Kaneko, Saeka Miyawaki, Yuki Habu, Yui Shiiyama, Kie Uchii, Yui Machida, Takuji Oyama, Isao Ishii

Publikováno v: Antioxidants, Vol 12, Iss 8, p 1523 (2023)

No therapeutic drugs are currently available for nonalcoholic steatohepatitis (NASH) that progresses from nonalcoholic fatty liver via oxidative stress-involved pathways. Three cognate peroxisome proliferator-activated receptor (PPAR) subtypes (PPAR�

Externí odkaz: https://doaj.org/article/0accaf46209a47e383198c9c9eddc003

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Akademický článek

Functional and Structural Insights into Human PPARα/δ/γ Subtype Selectivity of Bezafibrate, Fenofibric Acid, and Pemafibrate

Autor: Akihiro Honda, Shotaro Kamata, Makoto Akahane, Yui Machida, Kie Uchii, Yui Shiiyama, Yuki Habu, Saeka Miyawaki, Chihiro Kaneko, Takuji Oyama, Isao Ishii

Publikováno v: International Journal of Molecular Sciences, Vol 23, Iss 9, p 4726 (2022)

Among the agonists against three peroxisome proliferator-activated receptor (PPAR) subtypes, those against PPARα (fibrates) and PPARγ (glitazones) are currently used to treat dyslipidemia and type 2 diabetes, respectively, whereas PPARδ agonists a

Externí odkaz: https://doaj.org/article/81f5a994fd9540b9af50f73bc322649c

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Akademický článek

PPARα Ligand-Binding Domain Structures with Endogenous Fatty Acids and Fibrates

Autor: Shotaro Kamata, Takuji Oyama, Kenta Saito, Akihiro Honda, Yume Yamamoto, Keisuke Suda, Ryo Ishikawa, Toshimasa Itoh, Yasuo Watanabe, Takahiro Shibata, Koji Uchida, Makoto Suematsu, Isao Ishii

Publikováno v: iScience, Vol 23, Iss 11, Pp 101727- (2020)

Summary: Most triacylglycerol-lowering fibrates have been developed in the 1960s–1980s before their molecular target, peroxisome proliferator-activated receptor alpha (PPARα), was identified. Twenty-one ligand-bound PPARα structures have been dep

Externí odkaz: https://doaj.org/article/019e9a2e669140bd9f38f82355fbf354

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