Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Akihiko Urayama"'
Autor:
Jordan Kho, Urszula Polak, Ming-Ming Jiang, John D. Odom, Jill V. Hunter, Saima M. Ali, Lindsay C. Burrage, Sandesh C.S. Nagamani, Robia G. Pautler, Hannah P. Thompson, Akihiko Urayama, Zixue Jin, Brendan Lee
Publikováno v:
JCI Insight, Vol 8, Iss 17 (2023)
Nitric oxide (NO) is a critical signaling molecule that has been implicated in the pathogenesis of neurocognitive diseases. Both excessive and insufficient NO production have been linked to pathology. Previously, we have shown that argininosuccinate
Externí odkaz:
https://doaj.org/article/6775588bb4dc4e2abf6ec0fb79c6a418
Publikováno v:
Fluids and Barriers of the CNS, Vol 19, Iss 1, Pp 1-22 (2022)
Abstract Mucopolysaccharidoses comprise a set of genetic diseases marked by an enzymatic dysfunction in the degradation of glycosaminoglycans in lysosomes. There are eight clinically distinct types of mucopolysaccharidosis, some with various subtypes
Externí odkaz:
https://doaj.org/article/8201c221ddb84eaeba3801ff082ef1db
Autor:
Rodrigo Morales, Claudia Duran-Aniotz, Javiera Bravo-Alegria, Lisbell D. Estrada, Mohammad Shahnawaz, Ping-Ping Hu, Carlos Kramm, Diego Morales-Scheihing, Akihiko Urayama, Claudio Soto
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-16 (2020)
Abstract Previous studies showed that injection of tissue extracts containing amyloid-β (Aβ) aggregates accelerate amyloid deposition in the brain of mouse models of Alzheimer’s disease (AD) through prion-like mechanisms. In this study, we evalua
Externí odkaz:
https://doaj.org/article/0abd87e9c0524d7d9af4eb8a1dead7ab
Autor:
Brian Noh, Maria P. Blasco-Conesa, Yun-Ju Lai, Bhanu Priya Ganesh, Akihiko Urayama, Ines Moreno-Gonzalez, Sean P. Marrelli, Louise D. McCullough, Jose Felix Moruno-Manchon
Publikováno v:
Frontiers in Aging, Vol 2 (2022)
Senescence in the cerebral endothelium has been proposed as a mechanism that can drive dysfunction of the cerebral vasculature, which precedes vascular dementia. Cysteine-rich angiogenic inducer 61 (Cyr61/CCN1) is a matricellular protein secreted by
Externí odkaz:
https://doaj.org/article/6c4b12423416476bb2ad2cf9f5bf97fa
Autor:
Michael E. Maniskas, Alexis F. Mack, Diego Morales-Scheihing, Carson Finger, Liang Zhu, Robia Paulter, Akihiko Urayama, Louise D. McCullough, Bharti Manwani
Publikováno v:
Brain, Behavior, & Immunity - Health, Vol 14, Iss , Pp 100260- (2021)
Cerebral amyloid angiopathy (CAA) is one of the common causes of lobar intracerebral hemorrhage and vascular cognitive impairment (VCI) in the aging population. Increased amyloid plaque deposition within cerebral blood vessels, specifically the smoot
Externí odkaz:
https://doaj.org/article/489fab15574545fcac5ba4180078c41a
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Dementia is a neuropsychiatric syndrome characterized by cognitive decline in multiple domains, often leading to functional impairment in activities of daily living, disability, and death. The most common causes of age-related progressive dementia in
Externí odkaz:
https://doaj.org/article/f3d1c9d18fe84f6a93ad7c20069e37cf
Autor:
Jose F Moruno-Manchon, Pauline Lejault, Yaoxuan Wang, Brenna McCauley, Pedram Honarpisheh, Diego A Morales Scheihing, Shivani Singh, Weiwei Dang, Nayun Kim, Akihiko Urayama, Liang Zhu, David Monchaud, Louise D McCullough, Andrey S Tsvetkov
Publikováno v:
eLife, Vol 9 (2020)
Guanine-rich DNA sequences can fold into four-stranded G-quadruplex (G4-DNA) structures. G4-DNA regulates replication and transcription, at least in cancer cells. Here, we demonstrate that, in neurons, pharmacologically stabilizing G4-DNA with G4 lig
Externí odkaz:
https://doaj.org/article/ccedf7803d294eb9966a7c80457c63fa
Autor:
Akihiko Urayama, Shinya Dohgu, Sandra M Robinson, William S Sly, Jeffery H Grubb, William A Banks
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0142347 (2015)
The impermeability of the adult blood-brain barrier (BBB) to lysosomal enzymes impedes the ability to treat the central nervous system manifestations of lysosomal storage diseases. Here, we found that simultaneous stimulation of the alpha1 and alpha2
Externí odkaz:
https://doaj.org/article/07b7ca41fa7c47d6af2fb8e43771832b
Autor:
Fan Bu, Jia-Wei Min, Razzaque, Md Abdur, El Hamamy, Ahmad, Patrizz, Anthony, Li Qi, Akihiko Urayama, Jun Li
Publikováno v:
Neural Regeneration Research; Apr2024, Vol. 19 Issue 4, p881-886, 6p
Autor:
Rocio Diaz Escarcega, Abhijeet A Patil, Jose Felix Moruno Manchon, Akihiko Urayama, Yuri A. Dabaghian, Rodrigo Morales, Louise D. McCullough, Andrey S. Tsvetkov
Publikováno v:
Alzheimer's & Dementia. 18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6443c31abc3f19e9f27be27bc509508c
https://doi.org/10.1002/alz.067196
https://doi.org/10.1002/alz.067196