Výsledky vyhledávání - "Akihiko Saiga"

Group X secretory phospholipase A2 can induce arachidonic acid release and eicosanoid production without activation of cytosolic phospholipase A2 alpha

Autor: Takao Shimizu, Yoshikazu Ishimoto, Kohji Hanasaki, Takashi Ono, Hitoshi Arita, Kaoru Seno, Naonori Uozumi, Akihiko Saiga

Publikováno v: Prostaglandins & Other Lipid Mediators. 75:79-89

Group X secretory phospholipase A2 (sPLA2-X) and cytosolic phospholipase A2 alpha (cPLA2alpha) are involved in the release of arachidonic acid (AA) from membrane phospholipids linked to the eicosanoid production in various pathological states. Recent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b01145d0ec5d20dc640ba5470cd674cd
https://doi.org/10.1016/j.prostaglandins.2004.10.001

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Mouse Group X Secretory Phospholipase A2 Induces a Potent Release of Arachidonic Acid from Spleen Cells and Acts as a Ligand for the Phospholipase A2 Receptor

Autor: Noriko Suzuki, Kohji Hanasaki, Kazumi Nakano, Hitoshi Arita, Jun Ishizaki, Noriko Fujii, Minoru Ikeda, Yasunori Yokota, Akihiko Saiga, Yasuhide Morioka, Takashi Ono

Publikováno v: Archives of Biochemistry and Biophysics. 381:31-42

Group X secretory phospholipase A2 (sPLA2-X) has recently been shown to possess a powerful potency for releasing arachidonic acid from cell membrane phospholipids. Here, we report the purification of mouse pro- and mature forms of sPLA2-X, as well as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1ea5cff0d908a016e284a94b02044cd
https://doi.org/10.1006/abbi.2000.1977

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Purified Group X Secretory Phospholipase A2 Induced Prominent Release of Arachidonic Acid from Human Myeloid Leukemia Cells

Autor: Takashi Ono, Keiko Kawamoto, Katsutoshi Yamada, Ken-ichi Higashino, Kohji Hanasaki, Akihiko Saiga, Minoru Ikeda, Kazumi Nakano, Hitoshi Arita, Yasuhide Morioka, Jun Ishizaki

Publikováno v: Journal of Biological Chemistry. 274:34203-34211

Group X secretory phospholipase A(2) (sPLA(2)-X) possesses several structural features characteristic of both group IB and IIA sPLA(2)s (sPLA(2)-IB and -IIA) and is postulated to be involved in inflammatory responses owing to its restricted expressio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b69ded59e2045ed1f023d4033887a0d8
https://doi.org/10.1074/jbc.274.48.34203

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Presence of antibodies to p21X and/or p27rex proteins in sera from human T-cell leukemia virus type I-infected individuals

Autor: Satoshi Orita, Kenichiro Kinoshita, Yuko Aono, Hisanaga Igarashi, Akihiko Saiga, Joko Imai

Publikováno v: Journal of Virological Methods. 57:157-168

The human T-cell leukemia virus type I (HTLV-I) pX gene encodes three nonstructural proteins, p40tax, p27rex and p21X. So far, natural antibodies to p27rex and/or p21X have not been found in sera from HTLV-I-infected individuals, although antibodies

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4668892c4fae593474f1c52029a4f601
https://doi.org/10.1016/0166-0934(95)01979-0

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Differences between group X and group V secretory phospholipase A2 in lipolytic modification of lipoproteins

Autor: Yoshikazu Ishimoto, Shigeki Kamitani, Katsutoshi Yamada, Kohji Hanasaki, Akihiko Saiga, Takashi Ono, Shigenori Yamamoto

Publikováno v: Cellular & Molecular Biology Letters

Secretory phospholipases A2 (sPLA2s) are a diverse family of low molecular mass enzymes (13–18 kDa) that hydrolyze the sn-2 fatty acid ester bond of glycerophospholipids to produce free fatty acids and lysophospholipids. We have previously shown th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fcdde00401e7d229025ab13c75c93f0
https://doi.org/10.2478/s11658-012-0019-2

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Synthesis and in vivo behavior of a copper-64-labeled dithiosemicarbazone derivative coupled to a dihydropyridine carrier

Autor: Akihiko Saiga, Hideo Saji, Akira Yokoyama, Yasuhiko Iida, Yasuhiro Magata

Publikováno v: Journal of Labelled Compounds and Radiopharmaceuticals. 33:127-135

The dihyropyridine ⇄ pyridinium salt redox delivery system was used to develop a perfusion agent that could be labeled with a generator-produced positron emitter 62Cu. A 64Cu-labeled dithiosemicarbazone (DTS) molecule attached to a dihyropyridine c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8fdea233996fe340f623b4e726c11ab9
https://doi.org/10.1002/jlcr.2580330207

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Human T cell leukaemia virus type 1 p21X mRNA: constitutive expression in peripheral blood mononuclear cells of patients with adult T cell leukaemia

Autor: Kenichiro Kinoshita, Akihiko Saiga, Shin Takagi, Naoko Minoura, Toshifumi Kondo, Yorio Hinuma, Hisanaga Igarashi, K. Araki, Satoshi Orita

Publikováno v: Journal of General Virology. 73:2283-2289

Although the p21X protein of human T cell leukaemia virus type 1 (HTLV-1) is generally thought to be expressed from a doubly spliced mRNA transcript (tax/rex mRNA) that encodes the p40tax, p27rex and p21X proteins, we have shown previously that a nov

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb2bb2e9a186f3606b1b8c24683d0fe7
https://doi.org/10.1099/0022-1317-73-9-2283

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The alpha isoform of diacylglycerol kinase exhibits arachidonoyl specificity with alkylacylglycerol

Autor: Nadia Bridgelal, Angela Kam, Richard M. Epand, and Akihiko Saiga, Matthew K. Topham

Publikováno v: Biochemistry. 43(46)

We compared the diacylglycerol kinase (DGK) catalyzed phosphorylation of 1-O-hexanoyl-2-oleoylglycerol (HOG) with 1-O-hexanoyl-2-arachidonoylglycerol (HAG). We assayed the activity of DGKalpha and DGKzeta using a liposomal-based assay system. Liposom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb6fbf8dfc89760fcc500e295ebffa76
https://pubmed.ncbi.nlm.nih.gov/15544348

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Potent modification of low density lipoprotein by group X secretory phospholipase A2 is linked to macrophage foam cell formation

Autor: Yoshikazu Ishimoto, Akihiko Saiga, Kohji Hanasaki, Katsutoshi Yamada, Shigenori Yamamoto, Takashi Ono, Hitoshi Arita, Minoru Ikeda, Shigeki Kamitani, Mitsuru Notoya

Publikováno v: The Journal of biological chemistry. 277(32)

The deposition of cholesterol ester within foam cells of the artery wall is fundamental to the pathogenesis of atherosclerosis. Modifications of low density lipoprotein (LDL), such as oxidation, are prerequisite events for the formation of foam cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::883d11ac8b1e1859cc0acd21731ae0cc
https://pubmed.ncbi.nlm.nih.gov/12021277

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Group X secretory phospholipase A(2) induces potent productions of various lipid mediators in mouse peritoneal macrophages

Autor: Yoshikazu Ishimoto, Yasuhide Morioka, Hitoshi Arita, Kohji Hanasaki, Akihiko Saiga, Kazumi Nakano, Takashi Ono

Publikováno v: Biochimica et biophysica acta. 1530(1)

We have previously shown the expression of group X secretory phospholipase A(2) (sPLA(2)-X) in mouse splenic macrophages and its powerful potency for releasing fatty acids from various intact cell membranes. Here, we examined the potency of sPLA(2)-X

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6148aa9fc095662ed3a82ee4c993e58
https://pubmed.ncbi.nlm.nih.gov/11341959

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