Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Akihiko Kuniyasu"'
Publikováno v:
BMC Cancer, Vol 18, Iss 1, Pp 1-12 (2018)
Abstract Background Nucleoporin Nup88, a component of nuclear pore complexes, is known to be overexpressed in several types of tumor tissue. The overexpression of Nup88 has been reported to promote the early step of tumorigenesis by inducing multinuc
Externí odkaz:
https://doaj.org/article/ca5131d451504589a0924b88272477ea
Autor:
Renata Pasqualini, Wadih Arap, Erkki Koivunen, George A. Calin, Jorge E. Cortes, Hagop M. Kantarjian, Susan O'Brien, Amado J. Zurita, Cecilia Rietz, Marina Cardó-Vila, Wouter H.P. Driessen, Akihiko Kuniyasu, Yan Sun, Laura Bover, Carlos Bueso-Ramos, Diana E. Jaalouk, Katja Karjalainen
Supplemental Figure 1. Cell surface expression of IL-11R in AML patient derived samples and hematopoietic cells from healthy bone marrow as analyzed by flow cytometry.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1afe52ab9f88cbc8f848df46f9be1973
https://doi.org/10.1158/1078-0432.22457781
https://doi.org/10.1158/1078-0432.22457781
Autor:
Renata Pasqualini, Wadih Arap, Erkki Koivunen, George A. Calin, Jorge E. Cortes, Hagop M. Kantarjian, Susan O'Brien, Amado J. Zurita, Cecilia Rietz, Marina Cardó-Vila, Wouter H.P. Driessen, Akihiko Kuniyasu, Yan Sun, Laura Bover, Carlos Bueso-Ramos, Diana E. Jaalouk, Katja Karjalainen
Supplemental Table 1. Features of synthesized analogs of BMTP-11 for drug-lead optimization.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83c5291e96a286cefc60d9c7ee0cd1f8
https://doi.org/10.1158/1078-0432.22457769
https://doi.org/10.1158/1078-0432.22457769
Autor:
Renata Pasqualini, Wadih Arap, Erkki Koivunen, George A. Calin, Jorge E. Cortes, Hagop M. Kantarjian, Susan O'Brien, Amado J. Zurita, Cecilia Rietz, Marina Cardó-Vila, Wouter H.P. Driessen, Akihiko Kuniyasu, Yan Sun, Laura Bover, Carlos Bueso-Ramos, Diana E. Jaalouk, Katja Karjalainen
Purpose: The IL11 receptor (IL11R) is an established molecular target in primary tumors of bone, such as osteosarcoma, and in secondary bone metastases from solid tumors, such as prostate cancer. However, its potential role in management of hematopoi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b233b1624b24723fc85d2ae6717a5eeb
https://doi.org/10.1158/1078-0432.c.6523689.v1
https://doi.org/10.1158/1078-0432.c.6523689.v1
Autor:
Renata Pasqualini, Wadih Arap, Erkki Koivunen, George A. Calin, Jorge E. Cortes, Hagop M. Kantarjian, Susan O'Brien, Amado J. Zurita, Cecilia Rietz, Marina Cardó-Vila, Wouter H.P. Driessen, Akihiko Kuniyasu, Yan Sun, Laura Bover, Carlos Bueso-Ramos, Diana E. Jaalouk, Katja Karjalainen
Supplemental Figure 3. Drug activity of BMTP-11 and BMTP#4 on a panel of established leukemia and lymphoma cell lines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::407d760b0e8f320ca5df7d83737e63e5
https://doi.org/10.1158/1078-0432.22457775
https://doi.org/10.1158/1078-0432.22457775
Autor:
Renata Pasqualini, Wadih Arap, Erkki Koivunen, George A. Calin, Jorge E. Cortes, Hagop M. Kantarjian, Susan O'Brien, Amado J. Zurita, Cecilia Rietz, Marina Cardó-Vila, Wouter H.P. Driessen, Akihiko Kuniyasu, Yan Sun, Laura Bover, Carlos Bueso-Ramos, Diana E. Jaalouk, Katja Karjalainen
Supplemental Figure Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42445d9bb00468c934352d98a6481f09
https://doi.org/10.1158/1078-0432.22457772.v1
https://doi.org/10.1158/1078-0432.22457772.v1
Autor:
Renata Pasqualini, Wadih Arap, Erkki Koivunen, George A. Calin, Jorge E. Cortes, Hagop M. Kantarjian, Susan O'Brien, Amado J. Zurita, Cecilia Rietz, Marina Cardó-Vila, Wouter H.P. Driessen, Akihiko Kuniyasu, Yan Sun, Laura Bover, Carlos Bueso-Ramos, Diana E. Jaalouk, Katja Karjalainen
Supplemental Figure 2. Cell membrane and cytoplasmic expression of IL-11R.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b61d03b914c96651b8ebfb951a2b7085
https://doi.org/10.1158/1078-0432.22457778.v1
https://doi.org/10.1158/1078-0432.22457778.v1
Acid-responsive HPMA copolymer-bradykinin conjugate enhances tumor-targeted delivery of nanomedicine
Autor:
Ondřej Lidický, Tomáš Etrych, Enoch Appiah, Robert Pola, Eliška Grossmanová, Mamoru Haratake, Hideaki Nakamura, Akihiko Kuniyasu
Publikováno v:
Journal of Controlled Release. 337:546-556
Obstructed blood flow and erratic blood supply in the tumor region attenuate the distribution and accumulation of nanomedicines in the tumor. Therefore, improvement of these conditions is crucial for efficient drug delivery. In this study, we designe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e68ce45c0cfc58defb70a27287bee5b
https://doi.org/10.1016/j.jconrel.2021.08.009
https://doi.org/10.1016/j.jconrel.2021.08.009
Autor:
Ryota Uchimura, Yasumi Mashiki, Masaki Makise, Rikako Shiraishi, Kumiko Higashi, Akihiko Kuniyasu, Yuumi Shutoku
Publikováno v:
Histochemistry and Cell Biology
Elevated expression of the nucleoporin Nup88, a constituent of the nuclear pore complex, is seen in various types of malignant tumors, but whether this overexpression contributes to the malignant phenotype has yet to be determined. Here, we investiga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d242361016bef276b2267c9153c2c4d
https://doi.org/10.1007/s00418-021-02020-w
https://doi.org/10.1007/s00418-021-02020-w
Autor:
Yuka Nakamura, Akihiko Kuniyasu, Yu Ishima, Ryota Tanaka, Ryo Kinoshita, Yuki Enoki, Yoshihiro Kobashigawa, Shiro Futaki, Hitoshi Maeda, Kento Nishida, Keisuke Hamasaki, Hiroshi Morioka, Shota Ichimizu, Masaki Otagiri, Toru Maruyama, Victor Tuan Giam Chuang, Hiroshi Watanabe
Publikováno v:
Journal of Controlled Release. 277:23-34
Human serum albumin (HSA) is a superior carrier for delivering extracellular drugs. However, the development of a cell-penetrating HSA remains a great challenge due to its low membrane permeability. We report herein on the design of a series of palmi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11c6e8034ba9c81c2cddb5ed6b6dac88
https://doi.org/10.1016/j.jconrel.2018.02.037
https://doi.org/10.1016/j.jconrel.2018.02.037