Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Akihiko Koyama"'
Autor:
Akihiko Koyama, Ryutei Inui
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract In the context of global climate change, monitoring focused on temperature and benthic animals in intertidal flats and the development of metrics to assess climate change and ecosystem responses are essential for a sustainable society. Howev
Externí odkaz:
https://doaj.org/article/2b360f86e2b840a98a60b613a66d17bf
Autor:
Hugo Geerts, Mike Walker, Rachel Rose, Silke Bergeler, Piet H. van derGraaf, Edgar Schuck, Akihiko Koyama, Sanae Yasuda, Ziad Hussein, Larisa Reyderman, Chad Swanson, Antonio Cabal
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 4, Pp 444-461 (2023)
Abstract Antibody‐mediated removal of aggregated β‐amyloid (Aβ) is the current, most clinically advanced potential disease‐modifying treatment approach for Alzheimer's disease. We describe a quantitative systems pharmacology (QSP) approach of
Externí odkaz:
https://doaj.org/article/d9e08080706b49e386d73cb4a04cf07d
Autor:
Eric McDade, Jeffrey L. Cummings, Shobha Dhadda, Chad J. Swanson, Larisa Reyderman, Michio Kanekiyo, Akihiko Koyama, Michael Irizarry, Lynn D. Kramer, Randall J. Bateman
Publikováno v:
Alzheimer’s Research & Therapy, Vol 14, Iss 1, Pp 1-17 (2022)
Abstract Background Lecanemab, a humanized IgG1 monoclonal antibody that targets soluble aggregated Aβ species (protofibrils), has demonstrated robust brain fibrillar amyloid reduction and slowing of clinical decline in early AD. The objective of th
Externí odkaz:
https://doaj.org/article/a6d9281674a5413f8b67e7a74816d854
Autor:
Seiichi Hayato, Osamu Takenaka, Sree Harsha Sreerama Reddy, Ishani Landry, Larisa Reyderman, Akihiko Koyama, Chad Swanson, Sanae Yasuda, Ziad Hussein
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 11, Iss 12, Pp 1578-1591 (2022)
Abstract Lecanemab is a humanized immunoglobulin G1 monoclonal antibody that selectively binds to soluble Aβ aggregate species, while demonstrating low affinity for Aβ monomer. This article describes the population pharmacokinetic (PK) and PK/pharm
Externí odkaz:
https://doaj.org/article/a4225fc1516d43588fdf82ef59d7e7a2
Autor:
Lorenzo Vilizzi, Marina Piria, Dariusz Pietraszewski, Oldřich Kopecký, Ivan Špelić, Tena Radočaj, Nikica Šprem, Kieu Anh T. Ta, Ali Serhan Tarkan, András Weiperth, Baran Yoğurtçuoğlu, Onur Candan, Gábor Herczeg, Nurçin Killi, Darija Lemić, Bettina Szajbert, David Almeida, Zainab Al-Wazzan, Usman Atique, Rigers Bakiu, Ratcha Chaichana, Dimitriy Dashinov, Árpad Ferincz, Guillaume Flieller, Allan S. Gilles Jr, Philippe Goulletquer, Elena Interesova, Sonia Iqbal, Akihiko Koyama, Petra Kristan, Shan Li, Juliane Lukas, Seyed Daryoush Moghaddas, João G. Monteiro, Levan Mumladze, Karin H. Olsson, Daniele Paganelli, Costas Perdikaris, Renanel Pickholtz, Cristina Preda, Milica Ristovska, Kristína Slovák Švolíková, Barbora Števove, Eliza Uzunova, Leonidas Vardakas, Hugo Verreycken, Hui Wei, Grzegorz Zięba
Publikováno v:
NeoBiota, Vol 76, Iss , Pp 211-236 (2022)
Electronic decision-support tools are becoming an essential component of government strategies to tackle non-native species invasions. This study describes the development and application of a multilingual electronic decision-support tool for screeni
Externí odkaz:
https://doaj.org/article/103ef441e2394a8f97ca8f1592012900
Autor:
Kazuto Yamashita, Masahiro Miura, Shunsuke Watanabe, Kengo Ishiki, Yuji Arimatsu, Junko Kawahira, Toshiko Kubo, Katsutaka Sasaki, Takayuki Arai, Kei Hagino, Yasuhiro Irino, Kota Nagai, David Verbel, Akihiko Koyama, Shobha Dhadda, Hayato Niiro, Shigeki Iwanaga, Toshiyuki Sato, Tomokazu Yoshida, Atsushi Iwata
Publikováno v:
Alzheimer’s Research & Therapy, Vol 14, Iss 1, Pp 1-10 (2022)
Abstract Background Clinicians, researchers, and patients alike would greatly benefit from more accessible and inexpensive biomarkers for neural β-amyloid (Aβ). We aimed to assess the performance of fully automated plasma Aβ immunoassays, which co
Externí odkaz:
https://doaj.org/article/b4ad83da56d5456eaf4df2dc531245d7
Autor:
Chad J. Swanson, Yong Zhang, Shobha Dhadda, Jinping Wang, June Kaplow, Robert Y. K. Lai, Lars Lannfelt, Heather Bradley, Martin Rabe, Akihiko Koyama, Larisa Reyderman, Donald A. Berry, Scott Berry, Robert Gordon, Lynn D. Kramer, Jeffrey L. Cummings
Publikováno v:
Alzheimer’s Research & Therapy, Vol 13, Iss 1, Pp 1-14 (2021)
Abstract Background Lecanemab (BAN2401), an IgG1 monoclonal antibody, preferentially targets soluble aggregated amyloid beta (Aβ), with activity across oligomers, protofibrils, and insoluble fibrils. BAN2401-G000-201, a randomized double-blind clini
Externí odkaz:
https://doaj.org/article/edd30e11757844c3a76924e96d5411df
Autor:
Chad J. Swanson, Yong Zhang, Shobha Dhadda, Jinping Wang, June Kaplow, Robert Y. K. Lai, Lars Lannfelt, Heather Bradley, Martin Rabe, Akihiko Koyama, Larisa Reyderman, Donald A. Berry, Scott Berry, Robert Gordon, Lynn D. Kramer, Jeffrey L. Cummings
Publikováno v:
Alzheimer’s Research & Therapy, Vol 14, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/9e3c60d518ed4e89a11178d614b7e937
Autor:
Akihiko Koyama, Taiga Hirata, Yuki Kawahara, Hiroki Iyooka, Haruka Kubozono, Norio Onikura, Shinji Itaya, Tomoko Minagawa
Publikováno v:
PLoS ONE, Vol 15, Iss 12, p e0244494 (2020)
The tri-spine horseshoe crab, Tachypleus tridentatus, is a threatened species that inhabits coastal areas from South to East Asia. A Conservation management system is urgently required for managing its nursery habitats, i.e., intertidal flats, especi
Externí odkaz:
https://doaj.org/article/e602b60f73c2449a8810380904b32a9a
Autor:
Julie A Harris, Akihiko Koyama, Sumihiro Maeda, Kaitlyn Ho, Nino Devidze, Dena B Dubal, Gui-Qiu Yu, Eliezer Masliah, Lennart Mucke
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e45881 (2012)
Accumulation of hyperphosphorylated tau in the entorhinal cortex (EC) is one of the earliest pathological hallmarks in patients with Alzheimer's disease (AD). It can occur before significant Aβ deposition and appears to "spread" into anatomically co
Externí odkaz:
https://doaj.org/article/f8e15b3e38db4db0b14cf7b0ad584b67