Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Akihiko Ishimura"'
Autor:
Rong Wang, Tadaaki Yamada, Kenji Kita, Hirokazu Taniguchi, Sachiko Arai, Koji Fukuda, Minoru Terashima, Akihiko Ishimura, Akihiro Nishiyama, Azusa Tanimoto, Shinji Takeuchi, Koshiro Ohtsubo, Kaname Yamashita, Tomoyoshi Yamano, Akihiro Yoshimura, Koichi Takayama, Kyoichi Kaira, Yoshihiko Taniguchi, Shinji Atagi, Hisanori Uehara, Rikinari Hanayama, Isao Matsumoto, Xujun Han, Kunio Matsumoto, Wei Wang, Takeshi Suzuki, Seiji Yano
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Cancer cells develop resistance to tyrosine kinase inhibitors targeting EGFR. Here, the authors explore the mechanism of resistance to one such inhibitor - osimertinib - and find that resistance is caused by increased expression and activation of the
Externí odkaz:
https://doaj.org/article/286176aadbbc411dbfd32550becc33c5
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e115684 (2014)
Histone methylation plays a crucial role in various biological and pathological processes including cancer development. In this study, we discovered that JARID2, an interacting component of Polycomb repressive complex-2 (PRC2) that catalyzes methylat
Externí odkaz:
https://doaj.org/article/e1cdd92f0a184722a973b2f6b6a95ef5
Autor:
Gerelsuren Batbayar, Akihiko Ishimura, Hanbing Lyu, Sasithorn Wanna-udom, Makiko Meguro-Horike, Minoru Terashima, Shin-ichi Horike, Takahisa Takino, Takeshi Suzuki
Publikováno v:
Biochemical and Biophysical Research Communications. 669:19-29
Autor:
Abdalla Ahmed, Jibran Nehal Syed, Lijun Chi, Yaxu Wang, Carmina Perez-Romero, Dorothy Lee, Etri Kocaqi, Amalia Caballero, Jielin Yang, Quetzalcoatl Escalante-Covarrubias, Akihiko Ishimura, Takeshi Suzuki, Lorena Aguilar-Arnal, Gerard Bryan Gonzales, Kyoung-Han Kim, Paul Delgado-Olguín
Publikováno v:
Nature Cardiovascular Research. 2:174-191
Cardiac metabolism is deranged in heart failure, but underlying mechanisms remain unclear. Here, we show that lysine demethylase 8 (Kdm8) maintains an active mitochondrial gene network by repressing Tbx15, thus preventing dilated cardiomyopathy leadi
Autor:
Hanbing Lyu, Sasithorn Wanna-udom, Takahisa Takino, Takeshi Suzuki, Minoru Terashima, Matomo Sakari, Toshifumi Tsukahara, Akihiko Ishimura
Publikováno v:
Biochemical and Biophysical Research Communications. 524:150-155
N6-Methyladenosine (m6A) is the most common internal chemical modification of mRNAs involved in many pathological processes including various cancers. In this study, we investigated the role of m6A methyltransferase METTL3 in TGF-β-induced epithelia
Autor:
Kusuma, Suphakhong, Minoru, Terashima, Sasithorn, Wanna-Udom, Risa, Takatsuka, Akihiko, Ishimura, Takahisa, Takino, Takeshi, Suzuki
Publikováno v:
Journal of Biological Chemistry. 298:102554
N6-methyladenosine (m6A) is the most common internal chemical modification of mRNAs involved in many pathological processes including various cancers. In this study, we investigated the m6A-dependent regulation of JUN and JUNB transcription factors (
Publikováno v:
Journal of Biological Chemistry. 293:18016-18030
Long noncoding RNAs (lncRNAs) are important regulatory molecules in various biological and pathological processes, including cancer development. We have previously shown that the MEG3 lncRNA plays an essential role in transforming growth factor-β (T
Publikováno v:
Journal of Biological Chemistry. 292:82-99
Histone methylation is implicated in a number of biological and pathological processes, including cancer development. In this study, we investigated the molecular mechanism for the recruitment of Polycomb repressive complex-2 (PRC2) and its accessory
Autor:
Sasithorn Wanna-udom, Takeshi Suzuki, Minoru Terashima, Kusuma Suphakhong, Takahisa Takino, Akihiko Ishimura
Publikováno v:
The Journal of Biological Chemistry
Polycomb repressive complex-1 (PRC1) induces transcriptional repression by regulating monoubiquitination of lysine 119 of histone H2A (H2AK119) and as such is involved in a number of biological and pathological processes including cancer development.
Autor:
Shinji Takeuchi, Yoshihiko Taniguchi, Kyoichi Kaira, Akihiro Yoshimura, Wei Wang, Shinji Atagi, Akihiro Nishiyama, Kunio Matsumoto, Xujun Han, Koji Fukuda, Hirokazu Taniguchi, Azusa Tanimoto, Tadaaki Yamada, Takeshi Suzuki, Isao Matsumoto, Akihiko Ishimura, Minoru Terashima, Kenji Kita, Rikinari Hanayama, Sachiko Arai, Tomoyoshi Yamano, Rong Wang, Koichi Takayama, Koshiro Ohtsubo, Seiji Yano, Kaname Yamashita, Hisanori Uehara
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
Nature Communications
Drug tolerance is the basis for acquired resistance to epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) including osimertinib, through mechanisms that still remain unclear. Here, we show that while AXL-low expressing EGFR mutat