Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Akihiko HOSHINO"'
Autor:
Kenzo Takahashi, Shiro Nakaike, Miyuki Hori, Akihiko Hoshino, Junji Kamon, Nobutomo Tsuruzoe, Yumiko Asakura, Takehisa Iwama, Shuya Takahashi, Masafumi Kawanishi
Publikováno v:
European Journal of Pharmacology. 618:63-69
We evaluated the effects of NT-702 (parogrelil hydrochloride, NM-702, 4-bromo-6-[3-(4-chlorophenyl) propoxy]-5-[(pyridine-3-ylmethyl) amino] pyridazin-3(2H)-one hydrochloride), a selective phosphodiesterase 3 inhibitor, on the asthmatic response in g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::062e93c5381f4c49f1d812131c37f0df
https://doi.org/10.1016/j.ejphar.2009.07.005
https://doi.org/10.1016/j.ejphar.2009.07.005
Autor:
Takafumi Jinushi, Takashi Nishimura, Akihiko Hoshino, Yoshitaka Tanaka, Kenji Chamoto, Shigeru Ashino, Tsuguhide Takeshima, Takanobu Sakurai, Hiroaki Ikeda, Yumiko Asakura, Yasuo Mita, Akiko Takaoka, Takashi Teramura, Shiro Nakaike, Takemasa Tsuji, Junko Matsuzaki
Publikováno v:
International Immunology. 16:1497-1505
When wild-type BALB/c mice were transferred with OVA-specific Th2 cells followed by OVA inhalation, a severe eosinophilia, mucus hypersecretion and airway hyper-responsiveness (AHR) was induced in parallel with a marked elevation of IL-4, IL-5 and IL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd5d7f283beeac01cf0022ceec1eeb5d
https://doi.org/10.1093/intimm/dxh151
https://doi.org/10.1093/intimm/dxh151
Critical role for OX40 ligand in the development of pathogenic Th2 cells in a murine model of asthma
Autor:
Akiko Takaoka, Hisaya Akiba, Hideo Yagita, Ko Okumura, Naoto Ishii, Yumiko Asakura, Akihiko Hoshino, Shiro Nakaike, Kazuo Sugamura, Takanobu Sakurai, Yoshitaka Tanaka, Yasuo Mita
Publikováno v:
European Journal of Immunology. 33:861-869
Bronchial asthma is characterized by massive infiltration of eosinophils and airway hyperreactivity (AHR), which are caused by overproduction of Th2 cytokines (IL-4, IL-5, and IL-13) by allergen-specific T cells. We recently demonstrated a critical c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bd58ac4f8bdaf9f2d0e6c3148ac1cf0
https://doi.org/10.1002/eji.200323455
https://doi.org/10.1002/eji.200323455
Autor:
Yoshitaka Tanaka, Yasuo Mita, Shiro Nakaike, Toshiaki Koda, Yuji Togashi, Takashi Nishimura, Yumiko Asakura, Takafumi Jinushi, Akiko Takaoka, Kazuhito Watanabe, Takemasa Tsuji, Kouji Matsushima, Akihiko Hoshino
Publikováno v:
The Journal of Immunology. 167:2349-2353
Ag-specific Th1 and Th2 cells have been demonstrated to play a critical role in the induction of allergic diseases. Here we have investigated the precise mechanisms of Th1-induced airway inflammation. Airway inflammation was induced in BALB/c mice by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da894974b10a3de9d007e429d7f7871c
https://doi.org/10.4049/jimmunol.167.4.2349
https://doi.org/10.4049/jimmunol.167.4.2349
Autor:
Koji Ito, Yumiko Asakura, Akihiko Hoshino, Akio Mori, Keiji Miyazawa, Matsunobu Suko, Takeo Ohmura, Hirokazu Okudaira, Yasushi Okumura, Satoshi Inoue, Osamu Kaminuma, Toyokazu Yokota
Publikováno v:
Blood. 89:2891-2900
Glucocorticoids (GC) have long been used as the most effective agents for the treatment of allergic diseases accompanied by eosinophilia such as chronic asthma and atopic dermatitis. The development of chronic eosinophilic inflammation is dependent o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecacec13f54534d102a8ccfe90bc4a25
https://doi.org/10.1182/blood.v89.8.2891
https://doi.org/10.1182/blood.v89.8.2891
Autor:
Matsunobu Suko, Tadashi Mikami, Akihiko Hoshino, Hirokazu Okudaira, Akio Mori, Takeo Ohmura, Osamu Kaminuma
Publikováno v:
International Archives of Allergy and Immunology. 113:331-334
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ad93ecd02f43840f6bf1364315d2d35
https://doi.org/10.1159/000237592
https://doi.org/10.1159/000237592
Autor:
Nobuo Tsuruoka, Yoko Nishizaki, Hirokazu Okudaira, Tadashi Mikami, Matsunobu Suko, Yasushi Okumura, Akio Mori, Takeo Ohmura, Osamu Kaminuma, Akihiko Hoshino, Koji Ito, Satoshi Inoue, Gen Sato
Publikováno v:
International Immunology. 8:1889-1895
The role of IL-2 in IL-5 synthesis of human helper T cells was investigated. All of the Der f II (a major allergen of house dust mite)-specific T cell clones established from atopic asthmatic patients produced both IL-2 and IL-4 upon activation (Th0
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebd39fbfecded504a61a4f6d410a74c7
https://doi.org/10.1093/intimm/8.12.1889
https://doi.org/10.1093/intimm/8.12.1889
Autor:
Akihiko Hoshino, Koji Ito, Omura T, Akio Mori, Hirokazu Okudaira, Komatsu M, Keiji Miyazawa, Sugai M, Osamu Kaminuma
Publikováno v:
Japanese Journal of Clinical Immunology. 19:598-601
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08a488ddc4572c59a92d04447a8e6603
https://doi.org/10.2177/jsci.19.598
https://doi.org/10.2177/jsci.19.598
Publikováno v:
Biological Trace Element Research. 41:157-164
From the early stage of pancreatic adenocarcinoma in hamsters and also of hepatocellular carcinoma in rats, induced by treatment with N-nitrosobis (2-oxopropyl)amine and 3'-methyl-dimethylaminoazobenzene, respectively, hepatic levels of metallothione
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9afd42886cd75e96df8201dfa7ce3af1
https://doi.org/10.1007/bf02917225
https://doi.org/10.1007/bf02917225
Autor:
Akihiko Hoshino
Publikováno v:
Zairyo-to-Kankyo. 42:291-296
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ca01b5925c7f0cb715f2dc4e92a3e6f
https://doi.org/10.3323/jcorr1991.42.291
https://doi.org/10.3323/jcorr1991.42.291