Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Akihiko, Kiyoshi"'
Autor:
Tsuyoshi Takamura, Kenji Matsui, Naoto Matsumoto, Yatsumu Saito, Toshinari Fujimoto, Susumu Tajiri, Shuichiro Yamanaka, Kei Matsumoto, Akimitsu Kobayashi, Izumi Yamamoto, Hiroshi Sasaki, Haruyuki Hirayama, Hitomi Matsunari, Kazuaki Nakano, Hiroshi Nagashima, Akihiko Kiyoshi, Takao Kuroda, Makoto Inoue, Takeshi Miyawaki, Takashi Yokoo, Eiji Kobayashi
Publikováno v:
Engineering, Vol 10, Iss , Pp 65-73 (2022)
Controlling the immune response with only clinically approved immunosuppressant drugs is difficult in renal heterotransplantation from pigs to nonhuman primates. Moreover, to the best of our knowledge, no reports exist on the use of fetal pigs as kid
Externí odkaz:
https://doaj.org/article/3e9b46109b2843f2a42be4aa5f9ca0be
Techniques of orthotopic renal transplantation. II. Size-matched porcine grafts in monkey recipients
Autor:
Tsuyoshi Takamura, Hiroshi Sasaki, Haruyuki Hirayama, Akihiko Kiyoshi, Makoto Inoue, Kenji Matsui, Naoto Matsumoto, Yatsumu Saito, Toshinari Fujimoto, Susumu Tajiri, Shuichiro Yamanaka, Kei Matsumoto, Takeshi Miyawaki, Takashi Yokoo, Eiji Kobayashi
Publikováno v:
Acta Cirúrgica Brasileira, Vol 36, Iss 5 (2021)
ABSTRACT Purpose As a classical xenotransplantation model, porcine kidneys have been transplanted into the lower abdomen of non-human primates. However, we have improved upon this model by using size-matched grafting in the orthotopic position. The b
Externí odkaz:
https://doaj.org/article/5def744268c44824a705f5d0f55ee8e8
Autor:
Akihiko Kiyoshi, Isao Shimizu, Yasunori Katsura, Tadashi Tsubouchi, Kiyoko Bando, Seiko Oku, Shinji Tsujimoto, Toru Yamada, Kazuhiro Chihara, Yukiko Mine, Takeshi Kunimatsu
Publikováno v:
European Journal of Pharmacology. 826:96-105
The pharmacological activity of DSP-6952, a novel compound was investigated, compared to that of clinically efficacious gastrointestinal (GI) prokinetic 5-hydroxytryptamine 4 (5-HT 4 ) receptor agonists. DSP-6952 had a strong affinity of K i = 51.9 n
Autor:
Tadashi, Tsubouchi, Takeshi, Kunimatsu, Shinji, Tsujimoto, Akihiko, Kiyoshi, Yasunori, Katsura, Seiko, Oku, Kazuhiro, Chihara, Yukiko, Mine, Toru, Yamada, Isao, Shimizu, Kiyoko, Bando
Publikováno v:
European journal of pharmacology. 826
The pharmacological activity of DSP-6952, a novel compound was investigated, compared to that of clinically efficacious gastrointestinal (GI) prokinetic 5-hydroxytryptamine
Autor:
Yoshiharu Uruno, Atsushi Kitamura, Takeshi Enomoto, Akihiko Kiyoshi, Yoshiaki Ochi, Takaaki Sumiyoshi, Yasuko Konishi, Tomokazu Nakako, Atsushi Suwa, Harumi Matsuda, Kentaro Takai, Mutsuko Sakai, Yasuaki Uematsu
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:2909-2912
We designed and synthesized novel N-sulfonyl-7-azaindoline derivatives as selective M4 muscarinic acetylcholine receptor agonists. Modification of the N-carbethoxy piperidine moiety of compound 2, an M4 muscarinic acetylcholine receptor (mAChR)-prefe
Autor:
Yoko Takahashi, Yasuaki Uematsu, Mutsuko Sakai, Atsushi Kitamura, Harumi Matsuda, Kentaro Takai, Akihiko Kiyoshi, Takaaki Sumiyoshi, Yasuko Konishi, Tomokazu Nakako, Kengo Tojo, Atsushi Suwa, Yoshiharu Uruno, Takeshi Enomoto
Publikováno v:
ACS Medicinal Chemistry Letters. 4:244-248
Activation of the M1 and M4 muscarinic acetylcholine receptors is thought to play an important role in improving the symptoms of schizophrenia. However, discovery of selective agonists for these receptors has been a challenge, considering the high se
Autor:
Atsushi Matsumoto, Yuji Ogi, Masaru Ikejiri, Manato Kotani, Kazuhito Ikeda, Kenji Matsumoto, Tomokazu Nakako, Takeshi Murai, Takeshi Enomoto, Akihiko Kiyoshi, Tatsuo Nakayama, Yoshihiro Iwamura
Publikováno v:
Behavioural brain research. 305
Antagonism of the dopamine D3 receptor is considered a promising strategy for the treatment of cognitive impairment associated with schizophrenia. We have previously reported that the atypical antipsychotic blonanserin, a dopamine D2/D3 and serotonin
Autor:
Yasunori Katsura, Kiyoko Bando, Kazuhiro Chihara, Takeshi Kunimatsu, Tadashi Tsubouchi, Akihiko Kiyoshi, Yukiko Mine, Shinji Tsujimoto, Toru Yamada
Publikováno v:
Gastroenterology. 154:S-690
Autor:
Kenji Matsumoto, Atsushi Matsumoto, Yuji Ogi, Akihiko Kiyoshi, Kazuhito Ikeda, Manato Kotani, Masaru Ikejiri, Tomokazu Nakako, Takeshi Murai
Publikováno v:
Behavioural brain research. 300
Eye blinking is a spontaneous behavior observed in all mammals, and has been used as a well-established clinical indicator for dopamine production in neuropsychiatric disorders, including Parkinson's disease and Tourette syndrome [1,2]. Pharmacologic
Autor:
Atsushi Suwa, Harumi Matsuda, Kentaro Takai, Atsushi Kitamura, Tomokazu Nakako, Yasunao Inoue, Akihiko Kiyoshi, Takeshi Enomoto, Mutsuko Sakai, Gakuji Hashimoto, Yasuko Konishi, Yoshiharu Uruno, Yasuaki Uematsu, Takaaki Sumiyoshi, Hiroyuki Nishikawa
Publikováno v:
Bioorganicmedicinal chemistry letters. 24(14)
We designed and synthesized novel N-substituted 7-azaindoline derivatives as selective M1 and M4 muscarinic acetylcholine receptors (mAChRs) agonists. Hybridization of compound 2 with the HTS hit compound 5 followed by optimization of the N-substitue