Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Akihiko, Fujie"'
Publikováno v:
The Journal of antibiotics. 73(9)
Microbial transformation is known to be one of promising options to add functional groups such as a hydroxyl moiety to active base compounds to generate their derivatives. Sordaricin, a diterpene aglycone of the natural product sordarin, is an antifu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8aab49a1536779384862b9f5d7bc51a
https://pubmed.ncbi.nlm.nih.gov/32358585
https://pubmed.ncbi.nlm.nih.gov/32358585
Autor:
Akihiko Fujie
Publikováno v:
KAGAKU TO SEIBUTSU. 54:43-47
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bdf1d324ea9702aec8e055b251bd4fa5
https://doi.org/10.1271/kagakutoseibutsu.54.43
https://doi.org/10.1271/kagakutoseibutsu.54.43
Autor:
Shigehiro Takase, Masami Ezaki, Koji Yoshikawa, Michizane Hashimoto, Hirohito Kai, Kumiko Nitta, Akihiko Fujie, Ikuko Nakamura, Hideyuki Muramatsu, Masato Watanabe, Midori Yamashita, Noriaki Inamura
Publikováno v:
The Journal of Antibiotics. 66:465-471
The novel antifungal macrocyclic lipopeptidolactone, KB425796-A (1), was isolated from the fermentation broth of bacterial strain 530603, which was identified as a new Paenibacillus species based on morphological and physiological characteristics, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f69486f7c9fd771862ac5a84e21c705
https://doi.org/10.1038/ja.2013.63
https://doi.org/10.1038/ja.2013.63
Autor:
Hirohito Kai, Kumiko Nitta, Akihiko Fujie, Ikuko Nakamura, Koji Yoshikawa, Masato Watanabe, Midori Yamashita, Noriaki Inamura
Publikováno v:
The Journal of Antibiotics. 66:479-484
KB425796-C is a novel antifungal metabolite produced by the newly isolated bacterial strain Paenibacillus sp. No. 530603. This compound is a 40-membered macrocyclic lipopeptidolactone consisting of 12 amino acids and a 3-hydroxy-15-methylpalmitoyl mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c1554d7ee5157539eaab3c62fb6e9e9
https://doi.org/10.1038/ja.2013.57
https://doi.org/10.1038/ja.2013.57
Autor:
Akihiko Fujie, Shigetada Furukawa, Teruhisa Masaki, Keisuke Ohsumi, Ikuko Nakamura, Michizane Hashimoto, Seiji Yoshimura, Shigehiro Takase
Publikováno v:
The Journal of antibiotics. 70(1)
The novel antifungal agent ASP2397 (Vical's compound ID VL-2397) is produced by the fungal strain MF-347833 that was isolated from Malaysian leaf litter and is identified here as an Acremonium species based on its morphology, physiological properties
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a893779ce93338c8f1c0ac51ea4c00e
https://pubmed.ncbi.nlm.nih.gov/27599768
https://pubmed.ncbi.nlm.nih.gov/27599768
Autor:
Kazuhisa Sekimizu, Hiroshi Hamamoto, Ryuichi Kanasaki, Koji Yoshikawa, Shigetada Furukawa, Ikuko Nakamura, Akihiko Fujie
Publikováno v:
The Journal of antibiotics. 70(1)
Natural products are the major source of currently available drugs. However, screening natural product presents several challenges, including the time-consuming and labor-intensive steps required for the isolation of a drug from crude extracts as wel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::678520e2426488bd522f86511e59aa6c
https://pubmed.ncbi.nlm.nih.gov/27577982
https://pubmed.ncbi.nlm.nih.gov/27577982
Autor:
Shigehiro Takase, Satoshi Sasamura, Michizane Hashimoto, Motohiro Hino, Takashi Fujii, Hideyuki Muramatsu, Akihiko Fujie, Kazutoshi Sakamoto
Publikováno v:
The Journal of Antibiotics. 63:637-642
AS1387392 was a novel and powerful histone deacetylase inhibitor with an excellent oral absorption profile, but this compound was lacking in active moieties, which are essential to synthesize more derivatives. In our screening program to identify act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37adda7c316fe6c6d53c8fd978517761
https://doi.org/10.1038/ja.2010.89
https://doi.org/10.1038/ja.2010.89
Autor:
Ryuichi Kanasaki, Eisaku Tsujii, Motohiro Hino, Akihiko Fujie, Motoi Ueno, Takashi Fujii, Koji Takakura, Chihoko Ueno, Bunji Sato, Hidenori Nakajima, Akemi Kato, Yukiko Yamagishi
Publikováno v:
The Journal of Antibiotics. 62:95-98
In the previous study, we discovered a polyether antibiotic CP-44161, which was reported earlier as an anticoccidal agent, as an anti-varicella zoster virus compound. In this study, we demonstrated that CP-44161 had a very strong and broad anti-herpe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::484b30e7b3a5fbbdc1fc70a98b053cac
https://doi.org/10.1038/ja.2008.18
https://doi.org/10.1038/ja.2008.18
Autor:
Akihiko Fujie
Publikováno v:
Pure and Applied Chemistry. 79:603-614
FR901379, which is a novel, water-soluble, echinocandin-like lipopeptide, was isolated from a microbial culture broth. It showed potent in vivo antifungal activity against Candida albicans and inhibits the synthesis of 1,3-β-glucan. However, this co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::51530826f41acdaa3a1307bdb3cbacf0
https://doi.org/10.1351/pac200779040603
https://doi.org/10.1351/pac200779040603
Autor:
Fumie Abe, Ryuichi Kanasaki, Koji Yoshikawa, Yasuhiro Hori, Shigetada Furukawa, Akihiko Fujie, Seiji Hashimoto, Motohiro Hino
Publikováno v:
The Journal of Antibiotics. 59:145-148
The biological activities of the novel echinocandin-like lipopeptides, FR209602, FR209603 and FR209604, were evaluated. These compounds showed antifungal activity against Candida albicans and Aspergillus fumigatus attributed to inhibition of 1,3-beta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d11e9bbc22ddf62fbc44dbbfdac41b4
https://doi.org/10.1038/ja.2006.21
https://doi.org/10.1038/ja.2006.21