Výsledky vyhledávání - "Akiharu Hanamoto"

Different responses in mutagenesis induced by quinolone antibacterial agents in two Escherichia coli WP2uvrA/ pKM101 strains

Autor: Sunao Manabe, Satoru Itoh, Yayoi Hayasaki, Sanae Takada, Akiharu Hanamoto

Publikováno v: The Journal of Toxicological Sciences. 34:201-208

Escherichia coli WP2uvrA/pKM101 strain obtained from a different supplier had a lower response to quinolone antibacterial agents (quinolones) when compared to an ordinary responsive strain. The present study was designed to examine the mechanism of l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c37d187074b82b673af2b00962657720
https://doi.org/10.2131/jts.34.201

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PIGRET assay can detect mutagenicity of ethyl methanesulfonate much earlier than RBC Pig-a assay

Autor: Akiharu Hanamoto, Satoru Itoh, Shiho Nakayama, Chiharu Hattori

Publikováno v: Mutation research. Genetic toxicology and environmental mutagenesis. 811

The comparison between the original red blood cell (RBC) Pig-a assay, which measures Pig-a mutant RBCs, and the PIGRET assay, which uses reticulocytes, was conducted using in vivo mutagenesis by ethyl methanesulfonate (EMS) as a part of a collaborati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbeceed0d40c8bc598e5dc149a0d8cc1
https://pubmed.ncbi.nlm.nih.gov/27931801

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Genome sequence of an industrial microorganism Streptomyces avermitilis : Deducing the ability of producing secondary metabolites

Autor: Yoko Takahashi, Haruo Ikeda, Masahira Hattori, Akiharu Hanamoto, Hidekazu Nakazawa, Jun Ishikawa, Yoshiyuki Sakaki, Hisashi Kikuchi, Tomomi Osonoe, Satoshi Omura, Tadayoshi Shiba, Chigusa Takahashi, Hiroshi Horikawa, Mayumi Shinose

Publikováno v: Proceedings of the National Academy of Sciences. 98:12215-12220

Streptomyces avermitilis is a soil bacterium that carries out not only a complex morphological differentiation but also the production of secondary metabolites, one of which, avermectin, is commercially important in human and veterinary medicine. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07cf1f1492d1ccecc280c765caf0fcc1
https://doi.org/10.1073/pnas.211433198

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Overexpression of Phospholipid Hydroperoxide Glutathione Peroxidase Suppressed Cell Death Due to Oxidative Damage in Rat Basophile Leukemia Cells (RBL-2H3)

Autor: Nobuyoshi Chiba, Masayoshi Arai, Yasuhito Nakagawa, Daigo Sumi, Hirotaka Imai, Akiharu Hanamoto, Hikaru Sakamoto

Publikováno v: Biochemical and Biophysical Research Communications. 222:432-438

The role of phospholipid hydroperoxide glutathione peroxidase (PHGPx) in the cellular defense against oxidative stress was investigated in a novel cell model. We isolated stable transfectants of RBL-2H3 cells that overexpressed PHGPx. The activity of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f3c37eb24ea704228ccc9ca9e7207af
https://doi.org/10.1006/bbrc.1996.0762

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Up-regulation of phospholipid hydroperoxide glutathione peroxidase in rat casein-induced polymorphonuclear neutrophils

Autor: Akiharu Hanamoto, Yasuhito Nakagawa, Kazuhisa Furuhama, Hirotaka Imai, Hiroyuki Hattori

Antioxidant enzymes play key roles in the protection of cells from oxidative damage. Little is known, however, about the expression of antioxidants and/or their roles in PMNs (polymorphonuclear leucocytes), which are thought to suffer from oxidative

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2141914ee192a4b1890c9027b3c56543
https://europepmc.org/articles/PMC1175104/

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Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis

Autor: Satoshi Omura, Haruo Ikeda, Yoshiyuki Sakaki, Mayumi Shinose, Jun Ishikawa, Hisashi Kikuchi, Tadayoshi Shiba, Masahira Hattori, Akiharu Hanamoto

Publikováno v: Nature biotechnology. 21(5)

Species of the genus Streptomyces are of major pharmaceutical interest because they synthesize a variety of bioactive secondary metabolites. We have determined the complete nucleotide sequence of the linear chromosome of Streptomyces avermitilis. S.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f6dd43886b05a457ed80dd677db6fb8
https://pubmed.ncbi.nlm.nih.gov/12721573

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Molecular cloning and functional expression of a cDNA for rat phospholipid hydroperoxide glutathione peroxidase: 3'-untranslated region of the gene is necessary for functional expression

Autor: Nobuyoshi Chiba, Akiharu Hanamoto, Yasuhito Nakagawa, Akinori Sugiyama, Masayoshi Arai, Hirotaka Imai, Yoshiyuki Kuchino, Daigo Sumi

Publikováno v: Journal of biochemistry. 118(5)

A full-length cDNA clone for phospholipid hydroperoxide glutathione peroxidase (PHGPx) was isolated from a rat brain. The cDNA was 0.761 kb in length and encoded 170 amino acids, which included a TGA-encoded selenocysteine at residue 46. The protein

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9c7f5ca6fa170e7cbddad7d2e7e6bee
https://pubmed.ncbi.nlm.nih.gov/8749327

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