Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Akiharu FUJINO"'
Autor:
Akiharu Fujino, Hiroyuki Kusuhara, Kuninobu Yasuda, Ichiro Ieiri, Takao Watanabe, Yoshiaki Kitamura, Kenji Otsubo, Masaru Hirano, Kazuya Maeda, Yuichi Sugiyama, Hiroaki Fujiwara
Publikováno v:
Clinical Pharmacology & Therapeutics. 79:427-439
Objective Recent reports have shown that genetic polymorphisms in organic anion transporting polypeptide (OATP) 1B1 have an effect on the pharmacokinetics of drugs. However, the impact of OATP1B1*1b alleles, the frequency of which is high in all ethn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba52609be2b222e597a4e28afbf1f208
https://doi.org/10.1016/j.clpt.2006.01.011
https://doi.org/10.1016/j.clpt.2006.01.011
Autor:
Kunio Kakegawa, Osamu Izawa, Michio Ui, Eriko Koyama, Akiharu Fujino, Yuji Ohori, Norifumi Sakai, Ken Kitazawa
Publikováno v:
Food and Chemical Toxicology. 41:875-883
Stevia mixture, sweeteners extracted from the leaves of Stevia rebaudiana Bertoni, consists mainly of the glycosides of the diterpene derivative steviol. The aims of this study were to investigate the absorption (in rats) and the hepatic metabolism (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efa2986682474188c9214c883c4efbb6
https://doi.org/10.1016/s0278-6915(03)00039-5
https://doi.org/10.1016/s0278-6915(03)00039-5
Publikováno v:
Food and Chemical Toxicology. 41:359-374
Stevia mixture, sweeteners extracted from the leaves of Stevia rebaudiana Bertoni, consists mainly of stevioside and rebaudioside A (glycosides of the diterpene derivative steviol). The aim of this study was to investigate human intestinal metabolism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36942c38aea57ae0e24f69b774990c30
https://doi.org/10.1016/s0278-6915(02)00235-1
https://doi.org/10.1016/s0278-6915(02)00235-1
Autor:
Katsunori Nakamura, Akihiro Suzuki, Hiroshi Iwata, Akiharu Fujino, Tetsuya Kamataki, Hirotaka Kushida, Yuko Konno, Ken-ichi Fujita
Publikováno v:
Biochemical Pharmacology. 55:1315-1325
Forms of human cytochrome P450 (P450 or CYP), such as CYP1A1, CYP1A2, CYP2A6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP2E1, and CYP3A4, were expressed or co-expressed together with human NADPH-P450 reductase in Escherichia coli. When P450 was expressed al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0a226336ee45bdd9ebdc2293141e26b
https://doi.org/10.1016/s0006-2952(97)00643-6
https://doi.org/10.1016/s0006-2952(97)00643-6
Autor:
Akiharu Fujino, Kazuyoshi Suzuki, Jun Tatsuno, Seiu Iida, Tomio Inokuchi, Yukimi Yoneyama, Masato Iwamoto, Kunihiko Shibata, Minako Nozawa
Publikováno v:
Drug Metabolism and Pharmacokinetics. 5:699-710
The absorption, distribution, metabolism, excretion and accumulation of Betaxolol were investigated after repeated oral administration of 14C-Betaxolol (5mg/kg/day) to male rats for 21 days. The effect of Betaxolol on the hepatic drug-metabolizing en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66252d85aefb1296e87680c650414d93
https://doi.org/10.2133/dmpk.5.699
https://doi.org/10.2133/dmpk.5.699
Autor:
Seiu IIDA, Tomio INOKUCHI, Masato IWAMOTO, Masayuki SUZUKI, Yukimi YONEYAMA, Akiharu FUJINO, Kunihiko SHIBATA
Publikováno v:
Drug Metabolism and Pharmacokinetics. 5:675-697
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f20a54b64e47b75bf1b11599e9722a3f
https://doi.org/10.2133/dmpk.5.675
https://doi.org/10.2133/dmpk.5.675
Autor:
Takeo Ohba, Akiharu Fujino, Yuki Yanagida, Shinichi Ohta, Mamoru Kiyoki, Jun-ichi Sato, Youko Higaki, Chieri Yoshida
Publikováno v:
Drug Metabolism and Pharmacokinetics. 2:473-485
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09e4b7576e2e4445ebb5edf7dee0f93c
https://doi.org/10.2133/dmpk.2.473
https://doi.org/10.2133/dmpk.2.473
Publikováno v:
The Journal of Toxicological Sciences. 10:155-173
The antigenicity of difluprednate, phototoxicity and photocontact sensitivity of difluprednate ointment and cream were studied in guinea pigs and mice. The results in this study were as follows. 1) Guinea pigs immunized with difluprednate emulsified
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0751db85b866f7a47478f72791950c46
https://doi.org/10.2131/jts.10.155
https://doi.org/10.2131/jts.10.155
Autor:
Hiroki Tomisawa, Akiharu Fujino, Yusaku Ohtani, Hideo Fukazawa, Hiroko Saitoh, Tae Yajima, Shigeyasu Ichihara, Mitsuru Tateishi, Noriko Ichimoto
Publikováno v:
Drug Metabolism and Pharmacokinetics. 1:61-67
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a1b0ce7fb51606e516390fd2b4c3d16
https://doi.org/10.2133/dmpk.1.61
https://doi.org/10.2133/dmpk.1.61
Publikováno v:
Chemical and Pharmaceutical Bulletin. 24:2301-2304
Reactions with the simple aerobic hydroxylating system at moderate temperature were studied on the aqueous solutions of two varieties of bile acid. Ferrous sulfate was added to a buffered solution (pH 6.5-6.7) of nordeoxycholic acid which was bubbled
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5fc5d38c1b76357c2dc47b1b9b37293f
https://doi.org/10.1248/cpb.24.2301
https://doi.org/10.1248/cpb.24.2301