Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Akifumi Yafune"'
Autor:
Akifumi Yafune, Mamoru Narukawa
Publikováno v:
Pharmacoepidemiology and Drug Safety. 16:1146-1152
Purpose To investigate a suitable post-marketing safety study design, that is number of patients and duration of exposure, to well characterise adverse events (AEs) profiles under limited resources, fixed patient-months. Methods A simulation study is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e17925eeacf0902f93aa6e940e388cb
https://doi.org/10.1002/pds.1472
https://doi.org/10.1002/pds.1472
Publikováno v:
Journal of Biopharmaceutical Statistics. 17:827-837
In clinical trials, sometimes only a single drug concentration can be measured from a patient because of the patient's burden. In this case, the sampling point is usually identical for all patients. From a single concentration, we cannot generally ob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b4e15a4032d83fbd9dc0f089ac29969
https://doi.org/10.1080/10543400701513975
https://doi.org/10.1080/10543400701513975
Autor:
Takashi Fukuda, Akifumi Yafune, Kotaro Gomi, Toshiki Matsubara, Yasuyuki Seto, Keisho Chin, Toshiharu Yamaguchi, Masanori Tokunaga, Yo Kato, Kazuhiko Yamada, Takuyo Kozuka
Publikováno v:
Cancer Science. 98:937-942
T4 esophageal cancer is defined as the tumor invading adjacent structures, using tumor–node–metastasis (TNM) staging. For clinically T4 thoracic esophageal carcinoma, multimodality therapy, that is, neoadjuvant chemoradiotherapy (CRT) followed by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59ae1f88e9cd4f28ebd50358b994125e
https://doi.org/10.1111/j.1349-7006.2007.00479.x
https://doi.org/10.1111/j.1349-7006.2007.00479.x
Publikováno v:
Journal of Biopharmaceutical Statistics. 16:193-205
Population pharmacokinetic (PPK) analysis usually employs nonlinear mixed effects models using first-order linearization methods. It is well known that linearization methods do not always perform well in actual situations. To avoid linearization, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::044a2136beba735ec677ca46d6fbde32
https://doi.org/10.1080/10543400500508861
https://doi.org/10.1080/10543400500508861
Publikováno v:
Communications in Statistics - Theory and Methods. 34:2331-2343
Because of its flexibility and usefulness, Akaike Information Criterion (AIC) has been widely used for clinical data analysis. In general, however, AIC is used without paying much attention to sample size. If sample sizes are not large enough, it is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5dcaee2beab049e38c66d0a486f02ca3
https://doi.org/10.1080/03610920500257295
https://doi.org/10.1080/03610920500257295
Autor:
Mamoru Narukawa, Akifumi Yafune
Publikováno v:
Drug Information Journal. 39:353-360
Population pharmacokinetic studies with a single sampling design such as single-trough sampling have been frequently conducted in Japan, often with little statistical consideration to the sampling design as well as to the sample size. When pharmacoki
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c1f7f485abb7055e54a5fbe72b507cf5
https://doi.org/10.1177/009286150503900403
https://doi.org/10.1177/009286150503900403
Publikováno v:
Statistics in Medicine. 24:3417-3429
In clinical data analysis, the restricted maximum likelihood (REML) method has been commonly used for estimating variance components in the linear mixed effects model. Under the REML estimation, however, it is not straightforward to compare several l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e051f2ba6fd6f121cc90b8e82eb8f0a9
https://doi.org/10.1002/sim.2191
https://doi.org/10.1002/sim.2191
Autor:
Akifumi Yafune, Makio Ishiguro
Publikováno v:
Statistics in Medicine. 22:3045-3053
Since drug concentrations in blood are usually related to the effectiveness and toxicity, a confidence band for the drug concentrations gives useful information for the treatment. This paper proposes a simulation-based approach for constructing confi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b4e68623db92adf8e49841741da5b80
https://doi.org/10.1002/sim.1543
https://doi.org/10.1002/sim.1543
Autor:
Akifumi Yafune
Publikováno v:
Kampo Medicine. 52:319-323
漢方処方の有効性および安全性の評価では, 長期投与症例における評価がひとつの重要なポイントである。日常の臨床において, このような長期投与症例に関する評価を行うためのひとつ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::973e3bcf9c965299ee34a8fd6438c76f
https://doi.org/10.3937/kampomed.52.319
https://doi.org/10.3937/kampomed.52.319
Autor:
Akifumi Yafune
Publikováno v:
Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics. 32:101-105
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c558cbe263b4d66dd896f1b9b1aa54fe
https://doi.org/10.3999/jscpt.32.3_101
https://doi.org/10.3999/jscpt.32.3_101