Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Akie Honma"'
Autor:
Nobuaki Kimura, Kenji Maeda, Masahiro Nagase, Takuma Ikeda, Masahiro Kimura, Masatoshi Murakata, Akira Kawase, Akie Honma, Hitoshi Shimizu
Publikováno v:
Tetrahedron. 73:655-660
The regioselective bromine-lithium exchange reaction of 2,4-dibromo-1-(1-methoxy-1-methylethoxymethyl)benzene ( 2 ), which resulted in optimized selectivity of 220:1, is described. Applying this method to the synthesis of tofogliflozin ( 1 ) as a SGL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a6b951c6411b598eb720baa73d44a791
https://doi.org/10.1016/j.tet.2016.12.028
https://doi.org/10.1016/j.tet.2016.12.028
Autor:
Hiromitsu Kawata, Ayako Nishimoto, Nobuyuki Ishikura, Takao Houjo, Robert L. Vessella, Hitoshi Yoshino, Takashi Emura, Toshito Nakagawa, Kazutaka Tachibana, Haruhiko Sato, Miho Watanabe, Ryo Nakamura, Takuya Shiraishi, Masateru Ohta, Toshiaki Tsunenari, Yuko Aoki, Akie Honma, Eva Corey
Publikováno v:
International Journal of Oncology. 46:1560-1572
Resistance of prostate cancer to castration is currently an unavoidable problem. The major mechanisms underlying such resistance are androgen receptor (AR) overexpression, androgen-independent activation of AR, and AR mutation. To address this proble
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e627101cf3300cee571ab61aa5f6c0ee
https://doi.org/10.3892/ijo.2015.2860
https://doi.org/10.3892/ijo.2015.2860
Autor:
Hitoshi Yoshino, Muraoka Terushige, Kazutaka Tachibana, Akemi Mizutani, Takashi Emura, Takuya Shiraishi, Akie Honma
Publikováno v:
Synlett. 2011:1117-1120
Short-step and scalable transformations from 2,6-dibromopyridine to 6-bromopyridine-2-sulfonamide by means of halogen―metal exchange and subsequent reaction with sulfuryl chloride followed by amidation are established. Application of the method for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f57d2427a2ebbaa8de45489e989321e
https://doi.org/10.1055/s-0030-1259953
https://doi.org/10.1055/s-0030-1259953
Autor:
Takuya Shiraishi, Ayako Nishimoto, Toshito Nakagawa, Akie Honma, Masateru Ohta, Hitoshi Yoshino, Kazutaka Tachibana, Nobuyuki Ishikura, Toshiaki Tsunenari, Kentaro Furumoto, Ryo Nakamura, Kazuya Kimura, Hiromitsu Kawata, Haruhiko Sato, Miho Watanabe, Noriyuki Takata, Takashi Emura
Publikováno v:
Bioorganic & Medicinal Chemistry. 18:8150-8157
A series of 5,5-dimethylthiohydantoin derivatives were synthesized and evaluated for androgen receptor pure antagonistic activities for the treatment of castration-resistant prostate cancer. Since CH4933468, which we reported previously, had a proble
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b8d5bf575f9424ec05177698a77a811
https://doi.org/10.1016/j.bmc.2010.10.023
https://doi.org/10.1016/j.bmc.2010.10.023
Autor:
Muraoka Terushige, Akemi Mizutani, Hitoshi Yoshino, Takashi Emura, Kazutaka Tachibana, Akie Honma, Takuya Shiraishi
Publikováno v:
ChemInform. 42
A scalable one-pot transformation via halogen—metal exchange allows the preparation of various title compounds and analogues as important intermediates in drug synthesis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::31055d5136b669874da3afc331bac712
https://doi.org/10.1002/chin.201138138
https://doi.org/10.1002/chin.201138138
Autor:
Takashi Emura, Toshiaki Tsunenari, Robert L. Vessella, Nobuyuki Ishikura, Eva Corey, Masateru Ohta, Hiromitsu Kawata, Kazutaka Tachibana, Akie Honma, Haruhiko Sato, Yuko Aoki, Takao Houjo, Ryo Nakamura, Ayako Nishimoto, Toshito Nakagawa, Hitoshi Yoshino, Miho Watanabe, Takuya Shiraishi
Publikováno v:
Molecular Cancer Therapeutics. 8:A219-A219
Background: Prostate cancer resistant to total androgen depletion therapies is termed castration-resistant prostate cancer and novel therapeutic approaches are in demand. The mechanisms of castration resistance in prostate cancer are reported to be:
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25d1397220c3cdd4b13b31ede88f348c
https://doi.org/10.1158/1535-7163.targ-09-a219
https://doi.org/10.1158/1535-7163.targ-09-a219
Autor:
Miho Watanabe, Takashi Emura, Toshiaki Tsunenari, Kentaro Furumoto, Hiromitsu Kawata, Kazuya Kimura, Nobuyuki Ishikura, Hitoshi Yoshino, Toshito Nakagawa, Masateru Ohta, Akie Honma, Ryo Nakamura, Noriyuki Takata, Ayako Nishimoto, Takuya Shiraishi, Kazutaka Tachibana, Haruhiko Sato
Publikováno v:
Molecular Cancer Therapeutics. 8:A220-A220
Background: We hypothesized that the androgen receptor (AR) pure antagonists, which exhibit no agonist activities, would inhibit AR signaling completely and would be efficacious against castration-resistant prostate cancer (CRPC). Based on our unders
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f9ec66af5c88c6449dbf9566dc7f880
https://doi.org/10.1158/1535-7163.targ-09-a220
https://doi.org/10.1158/1535-7163.targ-09-a220
Autor:
NOBUYUKI ISHIKURA, HIROMITSU KAWATA, AYAKO NISHIMOTO, RYO NAKAMURA, TOSHIAKI TSUNENARI, MIHO WATANABE, KAZUTAKA TACHIBANA, TAKUYA SHIRAISHI, HITOSHI YOSHINO, AKIE HONMA, TAKASHI EMURA, MASATERU OHTA, TOSHITO NAKAGAWA, TAKAO HOUJO, COREY, EVA, VESSELLA, ROBERT L., YUKO AOKI, HARUHIKO SATO
Publikováno v:
International Journal of Oncology; 2015, Vol. 46 Issue 4, p1560-1572, 13p