PLK1 overexpression suppresses homologous recombination and confers cellular sensitivity to PARP inhibition.

Autor: Pae S; Department of Frontier Medicine, Institute of Medical Science, Graduate School of Medicine, St. Marianna University, Kawasaki, 2168511, Japan., Sedukhina AS; Department of Frontier Medicine, Institute of Medical Science, Graduate School of Medicine, St. Marianna University, Kawasaki, 2168511, Japan.; Shirokane Sanko Clinic Research Centre, Minato, 1080072, Japan., Sugiyama R; Department of Breast and Endocrine Surgery, Graduate School of Medicine, St. Marianna University, Kawasaki, 216-8511, Japan., Atanacio SJ; Shirokane Sanko Clinic Research Centre, Minato, 1080072, Japan., Ohara T; Department of Obstetrics and Gynecology, St. Marianna University School of Medicine, Kawasaki, 216-8511, Japan., Ishii M; Department of Obstetrics and Gynecology, St. Marianna University School of Medicine, Kawasaki, 216-8511, Japan., Minagawa K; Division of Genomic Epidemiology and Clinical Trials, Clinical Trials Research Center, Nihon University School of Medicine, Tokyo, Japan., Akichjev R; Shirokane Sanko Clinic Research Centre, Minato, 1080072, Japan.; Katholieke Universiteit Leuven, 3000, Leuven, Belgium., Go F; Shirokane Sanko Clinic Research Centre, Minato, 1080072, Japan.; K International School Tokyo, Koto, 1350021, Japan., Chandankeri Z; Shirokane Sanko Clinic Research Centre, Minato, 1080072, Japan.; K International School Tokyo, Koto, 1350021, Japan., Janjetic ZMM; Shirokane Sanko Clinic Research Centre, Minato, 1080072, Japan.; K International School Tokyo, Koto, 1350021, Japan., Sato E; Shirokane Sanko Clinic Research Centre, Minato, 1080072, Japan., Yamaura A; Shirokane Sanko Clinic Research Centre, Minato, 1080072, Japan., Meguro R; Shirokane Sanko Clinic Research Centre, Minato, 1080072, Japan.; University of Michigan Ann Arbor, Ann Arbor, MI, 48109, USA., Palanisamy K; Shirokane Sanko Clinic Research Centre, Minato, 1080072, Japan.; School of Medicine, University of Nottingham, Nottingham, NG7 2UH, UK., Maeda I; Department of Pathology, Kitasato University Kitasato Institute Hospital, Minato, 1080072, Japan.; Department of Pathology, Kitasato University School of Medicine, Sagamihara, 2520374, Japan., Takeuchi O; Biomedical Laboratory, Department of Research, Kitasato University Kitasato Institute Hospital, Tokyo, Japan., Suzuki N; Department of Obstetrics and Gynecology, St. Marianna University School of Medicine, Kawasaki, 216-8511, Japan., Yudo K; Department of Frontier Medicine, Institute of Medical Science, Graduate School of Medicine, St. Marianna University, Kawasaki, 2168511, Japan., Bernal JA; Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain., Sato K; Department of Frontier Medicine, Institute of Medical Science, Graduate School of Medicine, St. Marianna University, Kawasaki, 2168511, Japan. kosato@marianna-u.ac.jp.; Shirokane Sanko Clinic Research Centre, Minato, 1080072, Japan. kosato@marianna-u.ac.jp.

Publikováno v: Scientific reports [Sci Rep] 2024 Dec 28; Vol. 14 (1), pp. 31276. Date of Electronic Publication: 2024 Dec 28.