Zobrazeno 1 - 10 of 158 pro vyhledávání: '"Aki Tanabe"'
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Akademický článek
Extracellular matrix-inspired hydrogel of hyaluronan and gelatin crosslinked via a Link module with a transglutaminase reactive sequence
Autor: Masashi Okawa, Aki Tanabe, Seiichi Ohta, Satoru Nagatoishi, Kouhei Tsumoto, Taichi Ito
Publikováno v: Communications Materials, Vol 3, Iss 1, Pp 1-11 (2022)
Hydrogels are promising for tissue engineering, in particular for replacing the extracellular matrix. Here, an extracellular matrix inspired hydrogel is created from hyaluronan and gelatin, which cell culture and animal experiments shows to be biocom
Externí odkaz: https://doaj.org/article/ec2605a0300b4a49aa13c3e69763db60
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4
Analytical Method for Experimental Validation of Computer-Designed Antibody
Autor: Aki, Tanabe, Kouhei, Tsumoto
Publikováno v: Methods in molecular biology (Clifton, N.J.). 2552
In the computational design of antibodies, the interaction analysis between target antigen and antibody is an essential process to obtain feedback for validation and optimization of the design. Kinetic and thermodynamic parameters as well as binding
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::95b45a90c51d3cc05865435cd729d947
https://pubmed.ncbi.nlm.nih.gov/36346606
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5
Antibody recognition of complement factor H reveals a flexible loop involved in atypical hemolytic uremic syndrome pathogenesis
Autor: Takanori Yokoo, Aki Tanabe, Yoko Yoshida, Jose M.M. Caaveiro, Makoto Nakakido, Yoichiro Ikeda, Yoshihiro Fujimura, Masaneori Matsumoto, Kevin Entzminger, Toshiaki Maruyama, C.J. Okumura, Masaomi Nangaku, Kouhei Tsumoto
Publikováno v: J Biol Chem
Atypical hemolytic uremic syndrome (aHUS) is a disease associated with dysregulation of the immune complement system, especially of the alternative pathway (AP). Complement factor H (CFH), consisting of 20 domains called complement control protein (C
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06490d18e155ce302f1960c31539cef9
https://pubmed.ncbi.nlm.nih.gov/35868160
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8
Anion solvation enhanced by positive supercharging mutations preserves thermal stability of an antibody in a wide pH range
Autor: Daisuke Kuroda, Kouhei Tsumoto, Keisuke Kasahara, Raiji Kawade, Aki Tanabe, Satoru Nagatoishi
Publikováno v: Biochemical and biophysical research communications. 563
Proteins function through interactions with other molecules. In protein engineering, scientists often engineer proteins by mutating their amino acid sequences on the protein surface to improve various physicochemical properties. “Supercharging” i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aa243fd55e0daa8fccadbafa06dcfcc
https://pubmed.ncbi.nlm.nih.gov/34058475
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9
Development of biparatopic bispecific antibody possessing tetravalent scFv-Fc capable of binding to ROBO1 expressed in hepatocellular carcinoma cells
Autor: Takao Hamakubo, Kouhei Tsumoto, Yuji Watanabe, Aki Tanabe, Satoru Nagatoishi
Publikováno v: Journal of biochemistry. 170(2)
There is no standard structural format of the biparatopic bispecific antibody (bbsAb) which is used against the target molecule because of the diversity of biophysical features of bispecific antibodies (bsAbs). It is therefore essential that the inte
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78eb3f2dcf92572c04b9b0d1441c5701
https://pubmed.ncbi.nlm.nih.gov/33844018
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