Zobrazeno 1 - 10
of 123
pro vyhledávání: '"Aki Nakamura"'
Autor:
Takuro Nishikawa, Takahiro Tomoda, Aki Nakamura, Jun Nagahama, Akihito Tanaka, Shuji Kanmura, Mari Kirishima, Akihide Tanimoto, Tsubasa Okano, Takahiro Kamiya, Kentaro Okamoto, Susumu Kirimura, Tomohiro Morio, Yasuhiro Okamoto, Hirokazu Kanegane
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundChronic granulomatous disease (CGD) is an inborn immune disorder in which the phagocytic system cannot eradicate pathogens, and autoinflammation occurs. Approximately half of the patients have associated gastrointestinal symptoms. Although
Externí odkaz:
https://doaj.org/article/d9ead170c0344dfab632661dd731f86e
Autor:
Akihiro Hasegawa, Aki Nakamura-Takahashi, Masataka Kasahara, Nana Saso, Sonoko Narisawa, José Luis Millán, Osamu Samura, Haruhiko Sago, Aikou Okamoto, Akihiro Umezawa
Publikováno v:
Regenerative Therapy, Vol 18, Iss , Pp 168-175 (2021)
Hypophosphatasia (HPP) is a congenital skeletal disease. Impairment of bone mineralization and seizures are due to a deficiency of tissue-nonspecific alkaline phosphatase (TNAP). Enzyme replacement therapy (ERT) is available as a highly successful tr
Externí odkaz:
https://doaj.org/article/c9dde3dbb11342f7a7366c05cf01dec6
Autor:
Yuko Nitahara-Kasahara, Mutsuki Kuraoka, Posadas Herrera Guillermo, Hiromi Hayashita-Kinoh, Yasunobu Maruoka, Aki Nakamura-Takahasi, Koichi Kimura, Shin’ichi Takeda, Takashi Okada
Publikováno v:
Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-17 (2021)
Abstract Background Duchenne muscular dystrophy (DMD) is an inherited progressive disorder that causes skeletal and cardiac muscle deterioration with chronic inflammation. Dental pulp stem cells (DPSCs) are attractive candidates for cell-based strate
Externí odkaz:
https://doaj.org/article/65358317f4784c63b28e72c0c587a755
Autor:
Yuko Nitahara-Kasahara, Shuji Mizumoto, Yukiko U. Inoue, Shota Saka, Guillermo Posadas-Herrera, Aki Nakamura-Takahashi, Yuki Takahashi, Ayana Hashimoto, Kohei Konishi, Shinji Miyata, Chiaki Masuda, Emi Matsumoto, Yasunobu Maruoka, Takahiro Yoshizawa, Toshiki Tanase, Takayoshi Inoue, Shuhei Yamada, Yoshihiro Nomura, Shin'ichi Takeda, Atsushi Watanabe, Tomoki Kosho, Takashi Okada
Publikováno v:
Disease Models & Mechanisms, Vol 14, Iss 12 (2021)
Musculocontractural Ehlers-Danlos syndrome (mcEDS) is caused by generalized depletion of dermatan sulfate (DS) due to biallelic pathogenic variants in CHST14 encoding dermatan 4-O-sulfotransferase 1 (D4ST1) (mcEDS-CHST14). Here, we generated mouse mo
Externí odkaz:
https://doaj.org/article/18ac308ec99e4737bca148fc2a47dc8c
Autor:
Yuko Nitahara-Kasahara, Guillermo Posadas-Herrera, Shuji Mizumoto, Aki Nakamura-Takahashi, Yukiko U. Inoue, Takayoshi Inoue, Yoshihiro Nomura, Shin’ichi Takeda, Shuhei Yamada, Tomoki Kosho, Takashi Okada
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Carbohydrate sulfotransferase 14 (CHST14) encodes dermatan 4-O-sulfotransferase 1, a critical enzyme for dermatan sulfate (DS) biosynthesis. Musculocontractural Ehlers-Danlos syndrome (mcEDS) is associated with biallelic pathogenic variants of CHST14
Externí odkaz:
https://doaj.org/article/628c0d523aa044b4b5618df49eddeeef
Publikováno v:
Frontiers in Plant Science, Vol 12 (2021)
Root penetration into soils is fundamental for land plants to support their own aboveground parts and forage water and nutrients. To elucidate the molecular mechanisms underlying root mechanical penetration, mutants defective in this behavior need to
Externí odkaz:
https://doaj.org/article/9946e722e3d348bc89b81d06e0c718b1
Autor:
Kota Sowa, Chikako Nito, Masataka Nakajima, Satoshi Suda, Yasuhiro Nishiyama, Yuki Sakamoto, Yuko Nitahara-Kasahara, Aki Nakamura-Takahashi, Masayuki Ueda, Kazumi Kimura, Takashi Okada
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 10, Iss , Pp 281-290 (2018)
Hepatocyte growth factor (HGF) has neuroprotective effects against ischemia-induced injuries. Dental pulp stem cell (DPSC) transplantation attenuates tissue injury in the brain of rats with post-transient middle cerebral artery occlusion. We sought t
Externí odkaz:
https://doaj.org/article/1a3ab391f59241b8b860929d6858b436
Autor:
Ryo Ikeue, Aki Nakamura-Takahashi, Yuko Nitahara-Kasahara, Atsushi Watanabe, Takashi Muramatsu, Toru Sato, Takashi Okada
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 10, Iss , Pp 361-370 (2018)
Hypophosphatasia is an inherited disease caused by mutations in the gene encoding tissue-nonspecific alkaline phosphatase (TNALP), the major symptom of which is hypomineralization of the bones and teeth. We had recently demonstrated that TNALP-defici
Externí odkaz:
https://doaj.org/article/cda2464d2fb5447baed81ec3eacbf835
Autor:
Masataka Nakajima, Chikako Nito, Kota Sowa, Satoshi Suda, Yasuhiro Nishiyama, Aki Nakamura-Takahashi, Yuko Nitahara-Kasahara, Kiwamu Imagawa, Tohru Hirato, Masayuki Ueda, Kazumi Kimura, Takashi Okada
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 6, Iss C, Pp 102-111 (2017)
Interleukin (IL)-10 is a contributing factor to neuroprotection of mesenchymal stem cell (MSC) transplantation after ischemic stroke. Our aim was to increase therapeutic effects by combining MSCs and ex vivo IL-10 gene transfer with an adeno-associat
Externí odkaz:
https://doaj.org/article/50cd340585d2420d99166b436cb24786
Publikováno v:
PLoS Genetics, Vol 15, Iss 4, p e1008121 (2019)
Endocycle is a commonly observed cell cycle variant through which cells undergo repeated rounds of genome DNA replication without mitosis. Endocycling cells arise from mitotic cells through a switch of the cell cycle mode, called the mitotic-to-endoc
Externí odkaz:
https://doaj.org/article/8c740e48879547a9b2661ce161d3702d