The Inhibitory Effect of Kakkonto, Japanese Traditional (Kampo) Medicine, on Brain Penetration of Oseltamivir Carboxylate in Mice with Reduced Blood-Brain Barrier Function

Autor: Shinji Oshima, Yumiko Ochiai, Shingo Takenaka, Daisuke Kobayashi, Kousuke Ohara, Aki Kanamuro, Ayumi Maruyama, Shigeru Ohshima, Masayuki Akimoto, Akio Negishi, Nanami Fukuda, Seiichi Honma

Publikováno v: Evidence-Based Complementary and Alternative Medicine, Vol 2015 (2015)
Evidence-based Complementary and Alternative Medicine : eCAM

Oseltamivir phosphate (OP) is used to treat influenza virus infections. However, its use may result in central nervous system (CNS) adverse effects. In Japan, OP is used with Kampo formulations to improve clinical effectiveness. We evaluated the pote

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