Výsledky vyhledávání - "Aki Hiuge-Shimizu"

Akademický článek

A pilot investigation of visceral fat adiposity and gene expression profile in peripheral blood cells.

Autor: Masaya Yamaoka, Norikazu Maeda, Seiji Nakamura, Susumu Kashine, Yasuhiko Nakagawa, Aki Hiuge-Shimizu, Kohei Okita, Akihisa Imagawa, Yuji Matsuzawa, Ken-ichi Matsubara, Tohru Funahashi, Iichiro Shimomura

Publikováno v: PLoS ONE, Vol 7, Iss 10, p e47377 (2012)

Evidence suggests that visceral fat accumulation plays a central role in the development of metabolic syndrome. Excess visceral fat causes local chronic low-grade inflammation and dysregulation of adipocytokines, which contribute in the pathogenesis

Externí odkaz: https://doaj.org/article/e6e21fe917fc41d197632859279b894c

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High serum S100A8/A9 levels and high cardiovascular complication rate in type 2 diabetics with ultrasonographic low carotid plaque density

Autor: Tohru Funahashi, Iichiro Shimomura, Ken Kishida, Ayumu Hirata, Aki Hiuge-Shimizu, Hideaki Nakatsuji

Publikováno v: Diabetes Research and Clinical Practice. 97:82-90

Aims S100A8/A9 complex is an inflammation-associated biomarker, which binds toll-like receptor 4 and was associated with the receptor for advanced glycation end-products. S100A8 and S100A9 were accumulated in atherosclerotic lesions. High serum level

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e18ed0a5fe787d648a40c1880818af35
https://doi.org/10.1016/j.diabres.2012.01.026

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Metabolic syndrome correlates with polyvascular lesions detected by systemic vascular ultrasonography in Japanese people with type 2 diabetes

Autor: Tohru Funahashi, Iichiro Shimomura, Ken Kishida, Ayumu Hirata, Aki Hiuge-Shimizu, Hideaki Nakatsuji

Publikováno v: Diabetes Research and Clinical Practice. 96:e26-e29

Atherosclerosis is a systemic disease of blood vessels. We investigated clinical characteristics of Japanese type 2 diabetic patients with polyvascular lesions detected by systemic vascular ultrasonography. The results showed that the metabolic syndr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3bcc5d5d57dd6f5ac4c8681d03c5ebc
https://doi.org/10.1016/j.diabres.2012.01.020

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Qualitative score of systemic arteriosclerosis by vascular ultrasonography as a predictor of coronary artery disease in type 2 diabetes

Autor: Aki Hiuge-Shimizu, Ken Kishida, Hideaki Nakatsuji, Ayumu Hirata, Iichiro Shimomura, Tohru Funahashi

Publikováno v: Atherosclerosis. 219:623-629

Patients with type 2 diabetes mellitus (T2DM) are at risk of polyvascular comorbidities and poor prognosis. Non-invasive techniques for early prediction of coronary artery disease (CAD) are desirable to prevent cardiovascular events in these patients

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f013962351f31aa84e9d183d242ec085
https://doi.org/10.1016/j.atherosclerosis.2011.08.043

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Reduction of visceral fat correlates with the decrease in the number of obesity-related cardiovascular risk factors in Japanese with Abdominal Obesity (VACATION-J Study)

Autor: Iichiro Shimomura, Tetsuya Ohira, Rie Oka, Tohru Funahashi, Yuko Ishizaka, Minoru Okada, Tohru Nakagawa, Aki Hiuge-Shimizu, Naoya Watanabe, Tadashi Nakamura, Norihide Takaya, Minoru Yamakado, Shizu Suzuki, Toshiki Fukui, Ken Kishida, Yuji Matsuzawa, Tohru Yoshizumi, Hiroshi Fukuda

Publikováno v: Journal of atherosclerosis and thrombosis. 19(11)

AIM Visceral fat accumulation is associated with obesity-related cardiovascular risk factor accumulation and atherosclerosis. The present study investigated whether one-year reduction of the visceral fat area (VFA) correlates with a decrease in the n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::635e39cd544aecf8e8204c08c926460a
https://pubmed.ncbi.nlm.nih.gov/22785136

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Coexistence of visceral fat and multiple risk factor accumulations is strongly associated with coronary artery disease in Japanese (the VACATION-J study)

Autor: Aki Hiuge-Shimizu, Yoichi Nozaki, Iichiro Shimomura, Masaaki Okutsu, Hiroshi Kobayashi, Tohru Yoshizumi, Tohru Funahashi, Akihiro Nomura, Hiroyoshi Yokoi, Satoru Sumitsuji, Ryosuke Kametani, Tetsuya Ohira, Ken Kishida, Yuji Matsuzawa, Tadashi Nakamura

Publikováno v: Journal of atherosclerosis and thrombosis. 19(7)

Aim: Multiple risk factor syndrome is a target for the prevention of coronary artery disease (CAD). A cluster of multiple risk factors, such as hypertension, glucose intolerance, and/or dyslipidemia, is encountered in Japanese without and with excess

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eefef7758708f69346d9d14a2a236514
https://pubmed.ncbi.nlm.nih.gov/22472215

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Contribution of glucocorticoid-mineralocorticoid receptor pathway on the obesity-related adipocyte dysfunction

Autor: Tohru Funahashi, Iichiro Shimomura, Ayumu Hirata, Hideaki Nakatsuji, Norikazu Maeda, Takuya Okada, Aki Hiuge-Shimizu

Publikováno v: Biochemical and biophysical research communications. 419(2)

Aims Mineralocorticoid receptor (MR) blockade ameliorated insulin resistance with improvements in adipocytokine dysregulation, inflammation, and excess of reactive oxygen species (ROS) in obese adipose tissue and adipocytes, but its mechanism has not

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab9543d17bab0236691f7eeaddde900f
https://pubmed.ncbi.nlm.nih.gov/22326264

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Absolute value of visceral fat area measured on computed tomography scans and obesity-related cardiovascular risk factors in large-scale Japanese general population (the VACATION-J study)

Autor: Ken Kishida, Yuji Matsuzawa, Yuko Ishizaka, Iichiro Shimomura, Tohru Funahashi, Tadashi Nakamura, Rie Oka, Shizu Suzuki, Norihide Takaya, Tohru Yoshizumi, Toshiki Fukui, Minoru Okada, Tohru Nakagawa, Aki Hiuge-Shimizu, Minoru Yamakado, Naoya Watanabe, Hiroshi Fukuda

Publikováno v: Annals of medicine. 44(1)

The management of cardiovascular risk factors is important for prevention of atherosclerotic cardiovascular diseases (ACVD). Visceral fat accumulation plays an important role in the clustering of cardiovascular risk factors, leading to ACVD. The pres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d942e8ac941a21f63027a9b0fc3f834d
https://pubmed.ncbi.nlm.nih.gov/20964583

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Short-term effects of liraglutide on visceral fat adiposity, appetite, and food preference: a pilot study of obese Japanese patients with type 2 diabetes

Autor: Yuya Fujishima, Susumu Kashine, Aki Hiuge-Shimizu, Iichiro Shimomura, Junji Kozawa, Norikazu Maeda, Kana Inoue, Akihisa Imagawa, Kohei Okita, Tohru Funahashi

Publikováno v: Cardiovascular Diabetology, Vol 10, Iss 1, p 109 (2011)
Cardiovascular Diabetology

Background To examine the effects of liraglutide, a glucagon-like peptide-1 (GLP-1) analogue, on visceral fat adiposity, appetite, food preference, and biomarkers of cardiovascular system in Japanese patients with type 2 diabetes. Methods The study s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adc10c6668f0c78782ae9d0026a57ec9

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High prevalence of gastroesophageal reflux symptoms in type 2 diabetics with hypoadiponectinemia and metabolic syndrome

Autor: Tohru Funahashi, Kana Inoue, Hideaki Nakatsuji, Ayumu Hirata, Aki Hiuge-Shimizu, Iichiro Shimomura, Ken Kishida

Publikováno v: Nutrition & Metabolism
Nutrition & Metabolism, Vol 9, Iss 1, p 4 (2012)

Background The prevalence of gastroesophageal reflux disease (GERD) has been increasing worldwide. Abdominal obesity or visceral fat accumulation rather than simple obesity is associated with GERD. Previous reports demonstrated the association betwee

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d46567fc432b4a8f174b45e8694a6f60

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