Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Aki, Cynthia"'
Publikováno v:
Tetrahedron Letters. 50:5005-5008
Novel highly substituted hydroxy thiophene motifs were designed and synthesized as viable amido phenol and sulfonamido phenol bioisosteres. Hydroxy group-directed regioselective bromination and palladium-catalyzed amination of thienyl bromide via Buc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d8a411bbaf1f6045c2cfed9235f60872
https://doi.org/10.1016/j.tetlet.2009.06.085
https://doi.org/10.1016/j.tetlet.2009.06.085
Autor:
Jay S. Fine, James Fossetta, Minglang Wu, Waldemar Gonsiorek, Carol Terminelli, Richard W. Bond, Daniel Lundell, J. Robert Merritt, Aki Cynthia J, Jianhua Chao, Zhenmin He, R. William Hipkin, James Jakway, Younong Yu, Taveras Arthur G, Diane Rindgen, Gaifa Lai, Rosemary Mayer-Ezel, Xuedong Fan, Michael P. Dwyer, Chao Jianping, Hongchen Qiu, Biju J. Purakkattle, Hong Bian
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:1318-1322
Comprehensive SAR studies were undertaken in the 3,4-diaminocyclobut-3-ene-1,2-dione class of CXCR2/CXCR1 receptor antagonists to explore the role of the heterocycle on chemokine receptor binding affinities, functional activity, as well as oral expos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b68dac44b7899c04fed455963d2ae1a
https://doi.org/10.1016/j.bmcl.2008.01.024
https://doi.org/10.1016/j.bmcl.2008.01.024
Publikováno v:
Tetrahedron Letters. 48:791-794
A two-step convenient sequence for the synthesis of previously inaccessible mono-Boc-protected bis-N-heterocyclic alkyl substituted ether derivatives 4 is described. Mitsunobu protocol was applied to the preparation of pyridinyl ether precursor 5. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3223433e0a2606068323c98eabbfe50d
https://doi.org/10.1016/j.tetlet.2006.11.161
https://doi.org/10.1016/j.tetlet.2006.11.161
Autor:
Kaiser Bernd, Aki Cynthia J, Rosemary Mayer-Ezel, Chao Jianping, R. William Hipkin, Richard W. Bond, Taveras Arthur G, Daniel Lundell, Jianhua Chao, Laura L. Rokosz, Purakkattle J. Biju, James Jakway, Viyyoor M. Girijavallabhan, Jay S. Fine, Tara M. Stauffer, James Fossetta, Wei Wang, Ge Li, Hong Bian, J. Robert Merritt, Waldemar Gonsiorek, Xuedong Fan, Baldwin John J, Michael P. Dwyer, Carol Terminelli, Younong Yu, Diane Rindgen, Lynne E. Ozgur
Publikováno v:
Journal of Medicinal Chemistry. 49:7603-7606
Structure-activity studies on lead cyclobutenedione 3 led to the discovery of 4 (SCH 527123), a potent, orally bioavailable CXCR2/CXCR1 receptor antagonist with excellent cell-based activity. Compound 4 displayed good oral bioavailability in rat and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::227efbb06ddac971383b73c48f410aca
https://doi.org/10.1021/jm0609622
https://doi.org/10.1021/jm0609622
Autor:
Lalwani Tarik, Patricia C. Weber, Paul Kirschmeier, Mark E. Snow, Ming Liu, Amin A. Nomeir, Linda James, Viyyoor M. Girijavallabhan, William T. Windsor, Robert Patton, Aki Cynthia J, Corey Strickland, Frank Hollinger, Doll Ronald J, Chao Jianping, Taveras Arthur G
Publikováno v:
Journal of Medicinal Chemistry. 45:3854-3864
The 10-bromobenzocycloheptapyridyl farnesyl transferase inhibitor (FTI) Sch-66336 (1) is currently under clinical evaluation for the treatment of human cancers. During structure-activity relationship development leading to 1, 10-bromobenzocycloheptap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::519d505c7e685bc629614c709a3c3cf5
https://doi.org/10.1021/jm010463v
https://doi.org/10.1021/jm010463v
Autor:
Xuedong Fan, Michael P. Dwyer, James Jakway, Aki Cynthia J, Daniel Lundell, Diane Rindgen, Jay S. Fine, Taveras Arthur G, J. Robert Merritt, Younong Yu, Biju J. Purakkattle, Chao Jianping, Jonathan E. Phillips, Michael Minnicozzi, James Fosetta, Jianhua Chao, William Hipkin
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(13)
A novel series of cyclobutenedione centered C(4)-alkyl substituted furanyl analogs was developed as potent CXCR2 and CXCR1 antagonists. Compound 16 exhibits potent inhibitory activities against IL-8 binding to the receptors (CXCR2 Ki=1 nM, IC(50)=1.3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::520a0b8485fa54c20ee44e1739b30137
https://pubmed.ncbi.nlm.nih.gov/17459706
https://pubmed.ncbi.nlm.nih.gov/17459706
Autor:
Aki, Cynthia, Chao, Jianping, Ferreira, Johan A., Dwyer, Michael P., Yu, Younong, Chao, Jianhua, Merritt, Robert J., Lai, Gaifa, Wu, Minglang, Hipkin, R. William, Fan, Xuedong, Gonsiorek, Waldemar, Fosseta, James, Rindgen, Diane, Fine, Jay, Lundell, Daniel, Taveras, Arthur G., Biju, Purakkattle
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 1 August 2009 19(15):4446-4449
Autor:
Yu, Younong, Dwyer, Michael P., Chao, Jianping, Aki, Cynthia, Chao, Jianhua, Purakkattle, Biju, Rindgen, Diane, Bond, Richard, Mayer-Ezel, Rosemary, Jakway, James, Qiu, Hongchen, Hipkin, R. William, Fossetta, James, Gonsiorek, Waldemar, Bian, Hong, Fan, Xuedong, Terminelli, Carol, Fine, Jay, Lundell, Daniel, Merritt, J. Robert, He, Zhenmin, Lai, Gaifa, Wu, Minglang, Taveras, Arthur
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 2008 18(4):1318-1322
Autor:
Chao, Jianhua, Taveras, Arthur G., Chao, Jianping, Aki, Cynthia, Dwyer, Michael, Yu, Younong, Purakkattle, Biju, Rindgen, Diane, Jakway, James, Hipkin, William, Fosetta, James, Fan, Xuedong, Lundell, Daniel, Fine, Jay, Minnicozzi, Michael, Phillips, Jonathan, Merritt, J. Robert
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 2007 17(13):3778-3783
Publikováno v:
Tetrahedron Letters. 48:2435
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::51db2add8f7170e2e31130afa0b95e27
https://doi.org/10.1016/j.tetlet.2007.01.136
https://doi.org/10.1016/j.tetlet.2007.01.136