Association of Left Ventricular Systolic Dysfunction Among Carriers of Truncating Variants in Filamin C With Frequent Ventricular Arrhythmia and End-stage Heart Failure

Autor: Akhtar, MM, Lorenzini, M, Pavlou, M, Ochoa, JP, O'Mahony, C, Restrepo-Cordoba, MA, Segura-Rodriguez, D, Bermudez-Jimenez, F, Molina, P, Cuenca, S, Ader, F, Larranaga-Moreira, JM, Sabater-Molina, M, Garcia-Alvarez, MI, Arantzamendi, LG, Truszkowska, G, Ortiz-Genga, M, Ruiz, IS, Nielsen, SK, Rasmussen, TB, Mezcua, AR, Alvarez-Rubio, J, Eiskjaer, H, Gautel, M, Garcia-Pinilla, JM, Ripoll-Vera, T, Mogensen, J, Freire, JL, Rodriguez-Palomares, JF, Pena-Pena, ML, Rangel-Sousa, D, Palomino-Doza, J, Achaga, XA, Bilinska, Z, Golvano, EZ, Climent, V, Penalver, MN, Barriales-Villa, R, Charron, P, Yotti, R, Zorio, E, Jimenez-Jaimez, J, Garcia-Pavia, P, Elliott, PM, European Genetic Cardiomyopathies

Publikováno v: JAMA Cardiology
r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
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r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe

IMPORTANCE Truncating variants in the gene encoding filamin C (FLNCtv) are associated with arrhythmogenic and dilated cardiomyopathies with a reportedly high risk of ventricular arrhythmia. OBJECTIVE To determine the frequency of and risk factors ass

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::b6042053eec522b6ee37eb71853f459a
https://jamanetwork.com/journals/jamacardiology/article-abstract/2779769

Prevalence of TTR variants detected by whole-exome sequencing in hypertrophic cardiomyopathy

Autor: Lopes, LR, Futema, M, Akhtar, MM, Lorenzini, M, Pittman, A, Syrris, P, Elliott, PM

Background: A proportion of patients with hypertrophic cardiomyopathy (HCM) have a diagnosis of cardiac amyloidosis. Hereditary transthyretin amyloid cardiomyopathy (ATTRv-CM) is caused by mutations in the TTR gene. Our aim was to study the prevalenc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::7dab9ef21c50a7269414112a8e047bd9

CpG islands under selective pressure are enriched with H3K4me3, H3K27ac and H3K36me3 histone modifications. Akhtar MM, Scala G, Cocozza S, Miele G, Monticelli A

Autor: Akhtar MM, Scala G, Cocozza S, Miele G, Monticelli A.

Publikováno v: BMC evolutionary biology (Online) (2013).
info:cnr-pdr/source/autori:Akhtar MM, Scala G, Cocozza S, Miele G, Monticelli A./titolo:CpG islands under selective pressure are enriched with H3K4me3, H3K27ac and H3K36me3 histone modifications. Akhtar MM, Scala G, Cocozza S, Miele G, Monticelli A./doi:/rivista:BMC evolutionary biology (Online)/anno:2013/pagina_da:/pagina_a:/intervallo_pagine:/volume

BACKGROUND: Histone modification is an epigenetic mechanism that influences gene regulation in eukaryotes. In particular, histone modifications in CpG islands (CGIs) are associated with different chromatin states and with transcription activity. Chan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=cnr_________::2ee6f15b5e9c2955baa4d66382576548
https://publications.cnr.it/doc/275480

Pharmacokinetic profile of novel multi-layer stable effervescent tablet: a cross-over study with an established European brand in healthy young male adults.

Autor: Dani DH; Faculty of Pharmacy, Hamdard University Islamabad Campus, Islamabad, Pakistan. dr.danish@live.com., Shyum Naqvi SB; Faculty of Pharmacy, Hamdard University-Main Campus, Karachi, Pakistan., Akram M; Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Karachi, Pakistan., Ullah M; Faculty of Pharmacy, Hamdard University Islamabad Campus, Islamabad, Pakistan., Khaliq SA; Faculty of Pharmacy, Hamdard University-Main Campus, Karachi, Pakistan., Akhtar MM; Faculty of Pharmacy, Hamdard University Islamabad Campus, Islamabad, Pakistan., Abdullah O; Faculty of Pharmacy, Hamdard University Islamabad Campus, Islamabad, Pakistan., Badshah SF; Department of Pharmacy, Faculty of Medical and Health Sciences, University of Poonch, Rawalakot, Pakistan., Bourhia M; Swalife Biotech Ltd Unit 3D North Point House, North Point Business Park, Cork, Ireland. m.bourhia@uiz.ac.ma., Shazly GA; Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, 11451, Saudi Arabia., Bin Jardan YA; Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, 11451, Saudi Arabia., Fazil S; Department of Chemistry, University of Poonch Rawalakot, Rawalakot, Pakistan.

Publikováno v: BMC pharmacology & toxicology [BMC Pharmacol Toxicol] 2024 Nov 05; Vol. 25 (1), pp. 83. Date of Electronic Publication: 2024 Nov 05.

N-phenyl and N-benzyl substituted succinimides: Preclinical evaluation for their antihypertensive effect and underlying mechanism.

Autor: Qayyum MI; Department of Pharmacy, University of Peshawar, Peshawar, 25120, Pakistan; Department of Pharmacy, Faculty of Medical and Health Sciences, University of the Poonch, Rawalakot, AJ&K, Pakistan. Electronic address: minhasimran123@gmail.com., Ullah S; Department of Pharmacy, University of Peshawar, Peshawar, 25120, Pakistan. Electronic address: samiullah@uop.edu.pk., Rashid U; Department of Chemistry, COMSATS University Islamabad, Abbottabad Campus, 22060, Abbottabad, Pakistan. Electronic address: umerrashid@cuiatd.edu.pk., Sadiq A; Department of Pharmacy, University of Malakand, Chakdara, 18000 Dir (L), KP, Pakistan. Electronic address: sadiquom@yahoo.com., Mahnashi MH; Department of Pharmaceutical Chemistry, College of Pharmacy, Najran University, Najran, Saudi Arabia. Electronic address: matermaha@gmail.com., Khalil SUK; Department of Pharmacy, Abasyn University, Peshawar, Pakistan. Electronic address: saif.ullah1@abasyn.edu.pk., Akhtar MM; Hamdard Institute of Pharmaceutical Sciences, Hamdard University Islamabad Campus, Islamabad, Pakistan. Electronic address: akhtar.masoom@gmail.com.

Publikováno v: European journal of pharmacology [Eur J Pharmacol] 2024 Feb 05; Vol. 964, pp. 176195. Date of Electronic Publication: 2023 Dec 23.