Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Akhiad Bercovich"'
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-18 (2023)
Abstract We describe MCProj—an algorithm for analyzing query scRNA-seq data by projections over reference single-cell atlases. We represent the reference as a manifold of annotated metacell gene expression distributions. We then interpret query met
Externí odkaz:
https://doaj.org/article/c47689d1b8134d5d99489d00c41277ce
Publikováno v:
Genome Biology, Vol 23, Iss 1, Pp 1-18 (2022)
Abstract Scaling scRNA-seq to profile millions of cells is crucial for constructing high-resolution maps of transcriptional manifolds. Current analysis strategies, in particular dimensionality reduction and two-phase clustering, offer only limited sc
Externí odkaz:
https://doaj.org/article/2a1a5c68c836425e8a389cfa95ae0b8e
Autor:
Tzah Feldman, Akhiad Bercovich, Yoni Moskovitz, Noa Chapal-Ilani, Amanda Mitchell, Jessie J. F. Medeiros, Tamir Biezuner, Nathali Kaushansky, Mark D. Minden, Vikas Gupta, Michael Milyavsky, Zvi Livneh, Amos Tanay, Liran I. Shlush
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
The mutational mechanisms that produce insertions and deletions that lead to clonal hematopoiesis are poorly understood. Here the authors show evidence that frequent deletions that are relevant to myeloid malignancies could be produced by PARP1-depen
Externí odkaz:
https://doaj.org/article/5cd49203803b4c6e921be0f40f64c457
Autor:
Yael Baran, Akhiad Bercovich, Arnau Sebe-Pedros, Yaniv Lubling, Amir Giladi, Elad Chomsky, Zohar Meir, Michael Hoichman, Aviezer Lifshitz, Amos Tanay
Publikováno v:
Genome Biology, Vol 20, Iss 1, Pp 1-19 (2019)
Abstract scRNA-seq profiles each represent a highly partial sample of mRNA molecules from a unique cell that can never be resampled, and robust analysis must separate the sampling effect from biological variance. We describe a methodology for partiti
Externí odkaz:
https://doaj.org/article/9753d7773ac942dbb045658e3b7d0981
Autor:
N. Zioni, A. Akhiad Bercovich, N. Chapal-Ilani, Tal Bacharach, N. Rappoport, A. Solomon, R. Avraham, E. Kopitman, Z. Porat, M. Sacma, G. Hartmut, M. Scheller, C. Muller-Tidow, D. Lipka, E. Shlush, M. Minden, N. Kaushansky, Liran I. Shlush
Publikováno v:
Nature Communications. 14
Both fatty bone marrow (FBM) and somatic mutations in hematopoietic stem cells (HSCs), also termed clonal hematopoiesis (CH) accumulate with human aging. However it remains unclear whether FBM can modify the evolution of CH. To address this question,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4580081a942846d0db2269e6856312c6
https://doi.org/10.1038/s41467-023-36906-1
https://doi.org/10.1038/s41467-023-36906-1
We describe MCProj - an algorithm for analyzing query scRNA-seq data by projections over reference single cell atlases. We represent the reference as a manifold consisting of annotated metacell gene expression distributions. We then infer query metac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32b283723bbf067f3b81f09e8d382aea
https://doi.org/10.1101/2022.12.01.518678
https://doi.org/10.1101/2022.12.01.518678
Autor:
Amos Tanay, Zvi Livneh, Vikas Gupta, Mark D. Minden, Jessie J. F. Medeiros, Nathali Kaushansky, Liran I. Shlush, Tzah Feldman, Amanda Mitchell, Michael Milyavsky, Yoni Moskovitz, Tamir Biezuner, Noa Chapal-Ilani, Akhiad Bercovich
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
Nature Communications
The mutational mechanisms underlying recurrent deletions in clonal hematopoiesis are not entirely clear. In the current study we inspect the genomic regions around recurrent deletions in myeloid malignancies, and identify microhomology-based signatur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::584d2822f7612580ca0d4036323b9ce2
https://doaj.org/article/5cd49203803b4c6e921be0f40f64c457
https://doaj.org/article/5cd49203803b4c6e921be0f40f64c457
Autor:
Sander I. van Kasteren, Luuk Reinalda, Eyal David, Hanjie Li, Linda Y. Y. Chen, Anne van der Leun, Amos Tanay, Ido Amit, Mireille Toebes, Ton N. Schumacher, Akhiad Bercovich, Yaniv Lubling, Mirjam E. Hoekstra, Colinda L.G.J. Scheele, Jacco van Rheenen, Daniela S. Thommen, Michel J. van de Graaff
Publikováno v:
Nature Chemical Biology
Nature Chemical Biology, 17, 1139-1147
Nature Chemical Biology, 17, 1139-1147
The functional activity and differentiation potential of cells are determined by their interactions with surrounding cells. Approaches that allow unbiased characterization of cell states while at the same time providing spatial information are of maj
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f05bfda6555a45061a841f6c33d6ae7
https://hdl.handle.net/1887/3242834
https://hdl.handle.net/1887/3242834
Publikováno v:
Genome Biology
Scaling scRNA-seq to profile millions of cells is crucial for constructing high-resolution maps of transcriptional manifolds. Current analysis strategies, in particular dimensionality reduction and two-phase clustering, offer only limited scaling and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48ce47021b674cb22fbe9935c03e7976
https://pubmed.ncbi.nlm.nih.gov/35440087
https://pubmed.ncbi.nlm.nih.gov/35440087
Autor:
Anne van der Leun, Mirjam Hoekstra, Luuk Reinalda, Colinda Scheele, Mireille Toebes, Michel van de Graaff, Hanjie Li, Akhiad Bercovich, Yaniv Lubling, Eyal David, Daniela Thommen, Amos Tanay, Jacco van Rheenen, Ido Amit, Sander van Kasteren, Ton Schumacher
The functional activity and differentiation potential of cells is determined by their interaction with surrounding cells. Approaches that allow the unbiased characterization of cell states while at the same time providing spatial information are of m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90934c0ff5ec70f6a1d2d54c6f3daffb
https://doi.org/10.1101/2020.10.02.291096
https://doi.org/10.1101/2020.10.02.291096