Zobrazeno 1 - 10
of 1 384
pro vyhledávání: '"Akemichi"'
Autor:
Tomoya Nakamachi, Hirokazu Ohtaki, Tamotsu Seki, Sachiko Yofu, Nobuyuki Kagami, Hitoshi Hashimoto, Norihito Shintani, Akemichi Baba, Laszlo Mark, Ingela Lanekoff, Peter Kiss, Jozsef Farkas, Dora Reglodi, Seiji Shioda
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Dry eye disease is a complex condition with limited treatments. Here the authors show that mice lacking a multi-functional peptide PACAP develop dry eye-like signs that can be topically treated with PACAP peptide that stimulates tearing in mice, sugg
Externí odkaz:
https://doaj.org/article/d48095ef948f429dba72a08d3786bfe1
Autor:
Yukio Ago, Ryota Araki, Koji Yano, Toshiyuki Kawasaki, Shigeyuki Chaki, Atsuro Nakazato, Hirotaka Onoe, Hitoshi Hashimoto, Akemichi Baba, Kazuhiro Takuma, Toshio Matsuda
Publikováno v:
Journal of Pharmacological Sciences, Vol 118, Iss 2, Pp 295-298 (2012)
Isolation-induced abnormal behaviors are useful animal models for assessing potential anti-psychotic drugs. This study examined the effect of MGS0028, a selective metabotropic glutamate 2/3 receptor agonist, on abnormal behaviors such as hyperactivit
Externí odkaz:
https://doaj.org/article/4e2d714e64ac47989531a1512ba36cf8
Autor:
Michiyoshi Hatanaka, Norihiro Shibata, Norihito Shintani, Ryota Haba, Atsuko Hayata, Hitoshi Hashimoto, Akemichi Baba
Publikováno v:
Journal of Pharmacological Sciences, Vol 113, Iss 1, Pp 89-93 (2010)
The chemoattractant receptor–homologous molecule expressed on T-helper type 2 cells (CRTH2) is the most recently identified prostaglandin (PG) receptor for both PGD2 and 15-deoxy-Δ12,14-PGJ2 (15d-PGJ2). We examined the mechanism by which 15d-PGJ2
Externí odkaz:
https://doaj.org/article/1a96c98a8f5a4be98b11bb9b8172e711
Autor:
Ken-ichi Hamagami, Yusuke Sakurai, Norihito Shintani, Naoko Higuchi, Kazuya Ikeda, Hitoshi Hashimoto, Akinobu Suzuki, Hiroshi Kiyama, Akemichi Baba
Publikováno v:
Journal of Pharmacological Sciences, Vol 110, Iss 4, Pp 451-458 (2009)
Abstract.: Development of human chronic pancreatitis is associated with intrapancreatic accumulation of pituitary adenylate cyclase–activating polypeptide (PACAP) accompanied with an altered inflammatory response (Michalski et al., Am J Physiol Gas
Externí odkaz:
https://doaj.org/article/2b18a706089741fc9e8ad2b2eb59ce64
Publikováno v:
Journal of Pharmacological Sciences, Vol 110, Iss 2, Pp 218-222 (2009)
Abstract.: The involvement of Ca2+ entry via the Na+/Ca2+ exchanger (NCX) in myogenic constriction of rat posterior cerebral arteries was investigated. RT-PCR identified mRNA for NCX1, 2, and 3 in the arteries. Na+ removal increased [Ca2+]i, which wa
Externí odkaz:
https://doaj.org/article/e7b1089f279541f687b88fb77b039b44
Autor:
Rie Tsuchida, Masahiro Kubo, Mariko Kuroda, Yasuhiro Shibasaki, Norihito Shintani, Michikazu Abe, Katalin Köves, Hitoshi Hashimoto, Akemichi Baba
Publikováno v:
Journal of Pharmacological Sciences, Vol 109, Iss 3, Pp 396-402 (2009)
It has been demonstrated that treatment of hyperactive mice with psychostimulants produced a calming effect depending on serotonergic neurotransmission. Our previous study also showed that hyperactivity in mice lacking pituitary adenylate cyclase–a
Externí odkaz:
https://doaj.org/article/fc7e4a9bf616418d8f0af5dfac3fd551
Publikováno v:
Journal of Pharmacological Sciences, Vol 106, Iss 1, Pp 15-21 (2008)
Repeated administration of psychostimulants elicits a progressive enhancement of locomotor activity known as behavioral sensitization. Central dopamine (DA) neurons play key roles as the neural substrates mediating behavioral sensitization, but the r
Externí odkaz:
https://doaj.org/article/d57e9f7a35f748f5aa6a93583d0c8ee6
Autor:
Shuhei Tomimoto, Tatsuya Ojika, Norihito Shintani, Hitoshi Hashimoto, Ken-ichi Hamagami, Kazuya Ikeda, Masanori Nakata, Toshihiko Yada, Yusuke Sakurai, Takeshi Shimada, Yoshiko Morita, Chie Ishida, Akemichi Baba
Publikováno v:
Journal of Pharmacological Sciences, Vol 107, Iss 1, Pp 41-48 (2008)
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a neuropeptide implicated in several metabolic functions, including insulin secretion and sympathoadrenal activation. To clarify the roles of PACAP in maintenance of whole-body glucose and
Externí odkaz:
https://doaj.org/article/3f4ce9701bc4438abd0e8dc41757167d
Autor:
Yuko Takayasu, Junko Nakaki, Toshiyuki Kawasaki, Ken Koda, Yukio Ago, Akemichi Baba, Toshio Matsuda
Publikováno v:
Journal of Pharmacological Sciences, Vol 103, Iss 4, Pp 434-437 (2007)
Edaravone, a radical scavenger, prevents ischemia/reperfusion injury in the brain, but the detailed mechanism is not known. This study examines the effect of edaravone on mitochondrial permeability transition pore (PTP) in rat brain. Edaravone at 10
Externí odkaz:
https://doaj.org/article/4125f4d8f97d46c3994a5492133fb268
Autor:
Yukio Ago, Keiko Takahashi, Shigeo Nakamura, Hitoshi Hashimoto, Akemichi Baba, Toshio Matsuda
Publikováno v:
Journal of Pharmacological Sciences, Vol 104, Iss 2, Pp 153-158 (2007)
The behavior of isolation-reared mice has not yet been studied in the staircase test. The present study examined the effects of anxiolytic or anxiogenic agents and isolation rearing on the behavior of ddY (outbred) strain mice in the staircase test.
Externí odkaz:
https://doaj.org/article/105dff00308b4bfda2572e55fa03a88d