Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Akemi Mizutani"'
Autor:
Yoshiaki Watanabe, Haruhiko Sato, Hidetomo Kitamura, Tomoya Kotake, Yoshikazu Nishimura, Masaru Shimizu, Takashi Emura, Kotaro Ogawa, Toru Esaki, Toshito Nakagawa, Akemi Mizutani, Yoshiyuki Furuta, Shinichi Arai, Hiroshi Noda, Masateru Ohta, Tatsuya Tamura, Yoshiaki Isshiki
Publikováno v:
Journal of Medicinal Chemistry. 63:5089-5099
We have previously shown that the oral administration of the small molecule hPTHR1 agonist PCO371 and its lead compound, 1 (CH5447240) results in PTH-like calcemic and hypophostemic activity in thyroparathyroidectomized rats. However, 1 was converted
Autor:
Hitoshi Yoshino, Muraoka Terushige, Kazutaka Tachibana, Akemi Mizutani, Takashi Emura, Takuya Shiraishi, Akie Honma
Publikováno v:
Synlett. 2011:1117-1120
Short-step and scalable transformations from 2,6-dibromopyridine to 6-bromopyridine-2-sulfonamide by means of halogen―metal exchange and subsequent reaction with sulfuryl chloride followed by amidation are established. Application of the method for
Publikováno v:
Tetrahedron. 51:6419-6430
Deoxygenation of the 1,2-glycol (±)-5 was achieved at the position adjacent to the heterocycle through the cyclic carbonate (±)-14, providing the monohydroxy compound 6. This new method of regioselective deoxygenation was employed for the first syn
Autor:
Muraoka Terushige, Akemi Mizutani, Hitoshi Yoshino, Takashi Emura, Kazutaka Tachibana, Akie Honma, Takuya Shiraishi
Publikováno v:
ChemInform. 42
A scalable one-pot transformation via halogen—metal exchange allows the preparation of various title compounds and analogues as important intermediates in drug synthesis.
Autor:
Akemi Mizutani, Masatoshi Morisue, Takehiko Iida, Shigeyuki Shimizu, Michiko Tachinaka, Taisuke Itaya, Yasushi Sugimoto
Publikováno v:
Chemical and Pharmaceutical Bulletin. 41:252-261
(R)-[2-Carboxy-2-[(methoxycarbonyl)amino]ethyl]triphenylphosphonium chloride (1) was converted by treatment with anion exchange resin (HCO-3) into the inner salt 13h, which gave a better yield (43%) than 1 in the Wittig reaction with benzaldehyde to
Publikováno v:
ChemInform. 23
The phosphonium chloride 6 having an optically active amino acid moiety was synthesized from (S)-serine benzylester tosylate (2b) through a six-step route. The utility of 6 as a reagent for the Witting reaction was exemplified in the olefination with
Autor:
Akemi Mizutani, Masatoshi Morisue, Takehiko Iida, Shigeyuki Shimizu, Michiko Tachinaka, Taisuke Itaya, Yasushi Sugimoto
Publikováno v:
ChemInform. 25
(R)-[2-Carboxy-2-[(methoxycarbonyl)amino]ethyl]triphenylphosphonium chloride (1) was converted by treatment with anion exchange resin (HCO-3) into the inner salt 13h, which gave a better yield (43%) than 1 in the Wittig reaction with benzaldehyde to
Publikováno v:
ChemInform. 26
Deoxygenation of the 1,2-glycol (±)-5 was achieved at the position adjacent to the heterocycle through the cyclic carbonate (±)-14, providing the monohydroxy compound 6. This new method of regioselective deoxygenation was employed for the first syn
Publikováno v:
Chemical and Pharmaceutical Bulletin. 39:1407-1414
The phosphonium chloride 6 having an optically active amino acid moiety was synthesized from (S)-serine benzylester tosylate (2b) through a six-step route. The utility of 6 as a reagent for the Witting reaction was exemplified in the olefination with
Autor:
Taisuke Itaya, Akemi Mizutani
Publikováno v:
Tetrahedron Letters. 26:347-350
The Wittig reaction of 1-benzyl-7-formylwye (12) with (R)-[2-carboxy-2-[(methoxycarbonyl)amino]ethyl]triphenylphosphonium chloride (8) followed by successive methylation and reduction gave (-)-wybutine [(S)-1a].