Zobrazeno 1 - 10
of 99
pro vyhledávání: '"Ake T Lu"'
Autor:
Victoria J Sugrue, Joseph Alan Zoller, Pritika Narayan, Ake T Lu, Oscar J Ortega-Recalde, Matthew J Grant, C Simon Bawden, Skye R Rudiger, Amin Haghani, Donna M Bond, Reuben R Hore, Michael Garratt, Karen E Sears, Nan Wang, Xiangdong William Yang, Russell G Snell, Timothy A Hore, Steve Horvath
Publikováno v:
eLife, Vol 12 (2023)
Externí odkaz:
https://doaj.org/article/3a91ff2b152a430ebb04aa6413d17d2f
Autor:
Khyobeni Mozhui, Ake T Lu, Caesar Z Li, Amin Haghani, Jose Vladimir Sandoval-Sierra, Yibo Wu, Robert W Williams, Steve Horvath
Publikováno v:
eLife, Vol 11 (2022)
Changes in DNA methylation (DNAm) are linked to aging. Here, we profile highly conserved CpGs in 339 predominantly female mice belonging to the BXD family for which we have deep longevity and genomic data. We use a ‘pan-mammalian’ microarray that
Externí odkaz:
https://doaj.org/article/88f2f437c3004166bdc61a9aa1f6079f
Autor:
Fernanda Morales Berstein, Daniel L McCartney, Ake T Lu, Konstantinos K Tsilidis, Emmanouil Bouras, Philip Haycock, Kimberley Burrows, Amanda I Phipps, Daniel D Buchanan, Iona Cheng, the PRACTICAL consortium, Richard M Martin, George Davey Smith, Caroline L Relton, Steve Horvath, Riccardo E Marioni, Tom G Richardson, Rebecca C Richmond
Publikováno v:
eLife, Vol 11 (2022)
Background: Epigenetic clocks have been associated with cancer risk in several observational studies. Nevertheless, it is unclear whether they play a causal role in cancer risk or if they act as a non-causal biomarker. Methods: We conducted a two-sam
Externí odkaz:
https://doaj.org/article/4e1402d624c84c12b18465047e355ffa
Autor:
Victoria J Sugrue, Joseph Alan Zoller, Pritika Narayan, Ake T Lu, Oscar J Ortega-Recalde, Matthew J Grant, C Simon Bawden, Skye R Rudiger, Amin Haghani, Donna M Bond, Reuben R Hore, Michael Garratt, Karen E Sears, Nan Wang, Xiangdong William Yang, Russell G Snell, Timothy A Hore, Steve Horvath
Publikováno v:
eLife, Vol 10 (2021)
In mammals, females generally live longer than males. Nevertheless, the mechanisms underpinning sex-dependent longevity are currently unclear. Epigenetic clocks are powerful biological biomarkers capable of precisely estimating chronological age and
Externí odkaz:
https://doaj.org/article/901ed9d95cff4307a781c381e14cdfb3
Autor:
Jude Gibson, Tom C Russ, Toni-Kim Clarke, David M Howard, Robert F Hillary, Kathryn L Evans, Rosie M Walker, Mairead L Bermingham, Stewart W Morris, Archie Campbell, Caroline Hayward, Alison D Murray, David J Porteous, Steve Horvath, Ake T Lu, Andrew M McIntosh, Heather C Whalley, Riccardo E Marioni
Publikováno v:
PLoS Genetics, Vol 15, Iss 11, p e1008104 (2019)
'Epigenetic age acceleration' is a valuable biomarker of ageing, predictive of morbidity and mortality, but for which the underlying biological mechanisms are not well established. Two commonly used measures, derived from DNA methylation, are Horvath
Externí odkaz:
https://doaj.org/article/a3ae5f4eb91544119f3e3c5d7fd25cbe
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract We describe a framework that addresses concern that the rate of change in any aging biomarker displays a trivial inverse relation with maximum lifespan. We apply this framework to methylation data from the Mammalian Methylation Consortium. W
Externí odkaz:
https://doaj.org/article/3de765c1ee08412390200b12883bb164
Autor:
Joshua Zhang, Mary E. Sehl, Roger Shih, Elizabeth Crabb Breen, Fengxue Li, Ake T. Lu, Jay H. Bream, Priya Duggal, Jeremy Martinson, Steven M. Wolinsky, Otoniel Martinez-Maza, Christina M. Ramirez, Steve Horvath, Beth D. Jamieson
Publikováno v:
Frontiers in Bioinformatics, Vol 4 (2024)
Introduction: Highly active antiretroviral therapy (HAART) helps improve some measures of accelerated epigenetic aging in persons living with HIV (PLWH), but its overall impact on the epigenome is not fully understood.Methods: In this study, we analy
Externí odkaz:
https://doaj.org/article/b3905060df8f42c5b15b836f9f6b4669
Autor:
Kim M. Parsons, Amin Haghani, Joseph A. Zoller, Ake T. Lu, Zhe Fei, Steven H. Ferguson, Eva Garde, M. Bradley Hanson, Candice K. Emmons, Craig O. Matkin, Brent G. Young, William R. Koski, Steve Horvath
Publikováno v:
Molecular Ecology Resources.
Autor:
Eric Dec, James Clement, Kaiyang Cheng, George M. Church, Michael B. Fossel, David H. Rehkopf, Luis Rosero-Bixby, Michael S. Kobor, David TS. Lin, Ake T. Lu, Zhe Fei, Wei Guo, Yap Ching Chew, Xiaojing Yang, Sulistyo E. Dwi Putra, Alex P. Reiner, Adolfo Correa, Adrian Vilalta, Chiara Pirazzini, Giuseppe Passarino, Daniela Monti, Beatrice Arosio, Paolo Garagnani, Claudio Franceschi, Steve Horvath
Publikováno v:
GeroScience.
Claims surrounding exceptional longevity are sometimes disputed or dismissed for lack of credible evidence. Here, we present three DNA methylation-based age estimators (epigenetic clocks) for verifying age claims of centenarians. The three centenaria
Autor:
Elena Bernabeu, Daniel L McCartney, Danni A Gadd, Robert F Hillary, Ake T Lu, Lee Murphy, Nicola Wrobel, Archie Campbell, Sarah E Harris, David Liewald, Caroline Hayward, Cathie Sudlow, Simon R Cox, Kathryn L Evans, Steve Horvath, Andrew M McIntosh, Matthew R Robinson, Catalina A Vallejos, Riccardo E Marioni
Publikováno v:
Bernabeu, E, McCartney, D L, Gadd, D, Hillary, R, Lu, A T, Murphy, L, Wrobel, N, Campbell, A, Harris, S E, Liewald, D C, Hayward, C, Sudlow, C L M, Cox, S R, Evans, K L, Horvath, S, McIntosh, A M, Robinson, M R, Vallejos, C A & Marioni, R E 2023, ' Refining epigenetic prediction of chronological and biological age ', Genome Medicine, vol. 15, no. 1, 12 . https://doi.org/10.1186/s13073-023-01161-y
Background Epigenetic clocks can track both chronological age (cAge) and biological age (bAge). The latter is typically defined by physiological biomarkers and risk of adverse health outcomes, including all-cause mortality. As cohort sample sizes inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01d5814cca16d7ebc88338f68a25d155
https://www.pure.ed.ac.uk/ws/files/330163640/s13073_023_01161_y.pdf
https://www.pure.ed.ac.uk/ws/files/330163640/s13073_023_01161_y.pdf