Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Ake P. Elhammer"'
Autor:
Ake P. Elhammer, Peter Wuts, Lloyd J Simons, Brian P. Metzger, Rachel C Sterling, Jerry L. Slightom
Publikováno v:
ACS Medicinal Chemistry Letters. 6:645-649
The natural product aureobasidin A (AbA) is a potent, well-tolerated antifungal agent with robust efficacy in animals. Although native AbA is active against a number of fungi, it has little activity against Aspergillus fumigatus, an important human p
Publikováno v:
Gene. 431:67-79
The gene (aba1) encoding the NRPS complex responsible for the synthesis of the cyclic peptide antibiotic Aureobasidin A (AbA) in Aureobasidium pullulans BP-1938, was cloned using a combination of PCR and library screening approaches. The aba1 gene wa
Publikováno v:
FEBS Journal. 274:6037-6045
UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferases (GalNAc transferases), which initiate mucin-type O-glycan biosynthesis, have broad acceptor substrate specificities, and it is still unclear how they recognize peptides with different sequence
Publikováno v:
Cell Research. 11:28-36
PSGL-1, a specific ligand for P-, E- and L-selectin, was isolated from in vivo [3H]-glucosamine labeled HL-60 cells by a combination of wheat germ agglutinin-agarose and P- or E-selectin-agarose chromatography. N-linked oligosaccharides were released
Publikováno v:
Glycoconjugate Journal. 16:171-180
The in vitro and in vivo specificity of the family of peptide:N-acetylgalactosaminyltransferases (GalNAcT) is analyzed on the basis of the reactivity and/or inhibitory activity of peptides and protein segments. The transferases appear to be multi-sub
Publikováno v:
Glycoconjugate Journal. 15:975-985
P-selectin glypoprotein ligand-1, PSGL-1, a specific ligand for P-, E-, and L-selectin, was isolated from in vivo [3H]-glucosamine labeled HL-60 cells by a combination of wheat germ agglutinin and platelet P-selectin- or E-selectin receptor globulin-
Publikováno v:
The Journal of Cell Biology
Cell–cell and cell–matrix interactions play central roles in biological development, such as during fertilization, implantation, placenta formation, embryogenesis, cell differentiation, migration, and organ formation. These types of interactions
Publikováno v:
Analytical Biochemistry. 239:20-24
A rapid and simple method for quantitating the reaction product of UDP-GalNAc:polypeptide, N -acetylgalactosaminyltransferase (GalNAc-transferase) by scintillation proximity assay (SPA) was developed. The assay quantitates the radioactivity incorpora
Autor:
Li Ma, Paul A. Aeed, Jian-Guo Geng, Paul S. Kaytes, Ake P. Elhammer, Darwin Asa, Loretta Raycroft
Publikováno v:
Journal of Biological Chemistry. 270:11662-11670
P- and E-selectins belong to a family of Ca(2+)-dependent lectins and function as receptors for myeloid leukocytes. We have described a panel of monoclonal antibodies which recognize a sialoglycoprotein from human neutrophils and HL-60 promyelocytic
Publikováno v:
Fibrinolysis. 8:31-41
The asparagine-linked oligosaccharides on a recombinant tissue-type plasminogen activator analog, lacking the epidermal growth factor-like and kringle 1 domains (FK 2 P), synthesized by Chinese hamster ovary cells, have been characterized. In vivo [