Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Akbar Z. Shyadehi"'
1
Synthesis of tritium-labelled metabolites of ibuprofen
Autor: John J. Harding, Akbar Z. Shyadehi
Publikováno v: Journal of Labelled Compounds and Radiopharmaceuticals. 42:207-213
The two major metabolites of ibuprofen, 2-[4-(2-carboxypropyl)phenyl]propionic acid and 2-[4-(2-methyl-2-hydroxypropyl)phenyl]propionic acid, were labelled with tritium. The hydroxy-metabolite containing tritium at α- and β-carbons of the propionic
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c3c86d3907f39a2af543d74a74b73c54
https://doi.org/10.1002/(sici)1099-1344(199903)42:3<207::aid-jlcr210>3.0.co
Zobrazit plný text záznamu
2
The Mechanism of the Acyl-Carbon Bond Cleavage Reaction Catalyzed by Recombinant Sterol 14α-Demethylase of Candida albicans (Other Names Are: Lanosterol 14α-Demethylase, P-45014DM, and CYP51)
Autor: Steven L. Kelly, D. L. Corina, J. Neville Wright, David C. Lamb, Diane E. Kelly, Akbar Z. Shyadehi, Wolf-Hagen Schunck, Muhammad Akhtar
Publikováno v: Journal of Biological Chemistry. 271:12445-12450
The Candida albicans sterol 14 alpha-demethylase gene (P-45014DM, CYP51) was transferred to the yeast plasmid YEp51 placing it under the control of the GAL10 promoter. The resulting construct (YEp51:CYP51) when transformed into the yeast strain GRF18
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f5becb780fa4949e6cc6d67e67c9136
https://doi.org/10.1074/jbc.271.21.12445
Zobrazit plný text záznamu
3
Mechanism of the Acyl-Carbon Cleavage and Related Reactions Catalyzed by Multifunctional P-450s: Studies on Cytochrome P-45017.alpha
Autor: D. L. Corina, Muhammad Akhtar, J. Neville Wright, Akbar Z. Shyadehi, Sharon L. Miller
Publikováno v: Biochemistry. 33:4410-4418
It is now well-known that conventional cytochrome P-450s catalyze hydroxylation reactions using an iron mono-oxygen species, the structure of which, as inferred from chemical model studies, may be drrepresented by the following canonical forms: FeV==
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ced414c3d4452aea6e406d7ad3b14369
https://doi.org/10.1021/bi00180a039
Zobrazit plný text záznamu
4
Incorporation of label from18O2into acetate during side-chain cleavage catalysed by cytochrome P-45017α(17α-hydroxylase-17,20-lyase)
Autor: Akbar Z. Shyadehi, Muhammad Akhtar, Sharon L. Miller, J. Neville Wright, D. L. Corina
Publikováno v: J. Chem. Soc., Perkin Trans. 1. :263-267
Samples of pregnenolone and 17α-hydroxypregnenolone deuteriated at the C-21 methyl group have been prepared and subjected to side-chain cleavage with a pig testes microsomal preparation under 18O2. 17α-Hydroxypregnenolone was exclusively cleaved to
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::db819bd271c8f029bfbd25ccad72e978
https://doi.org/10.1039/p19940000263
Zobrazit plný text záznamu
5
Investigations of ibuprofen and paracetamol binding to lens proteins to explore their protective role against cataract
Autor: John J. Harding, Akbar Z. Shyadehi
Publikováno v: Biochemical Pharmacology. 42:2077-2084
There is evidence that ibuprofen and paracetamol can act as anti-cataract drugs. [14C]-Ibuprofen labelled at the methyl group of the propanoic acid moiety was synthesized. The labelled ibuprofen was found to bind non-covalently to alpha-crystallin bu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03ab191ba60c9030c4dea2bb8852c345
https://doi.org/10.1016/0006-2952(91)90341-2
Zobrazit plný text záznamu
6
Protective effects of ibuprofen and its major metabolites against in vitro inactivation of catalase and fumarase: relevance to cataract
Autor: John J. Harding, Akbar Z. Shyadehi
Publikováno v: Biochimica et biophysica acta. 1587(1)
Ibuprofen and its major metabolites were incubated with catalase and fumarase, in the presence of protein-modifying biomolecules, to explore the mode of action of ibuprofen in protection against cataract. Both 2 and 10 mM ibuprofen/metabolites protec
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eea5b9b281a77f8c4206feecc4b94aa5
https://pubmed.ncbi.nlm.nih.gov/12009421
Zobrazit plný text záznamu
7
The mutation T315A in Candida albicans sterol 14alpha-demethylase causes reduced enzyme activity and fluconazole resistance through reduced affinity
Autor: Muhammed Akhtar, Wolf-Hagen Schunck, Akbar Z. Shyadehi, David C. Lamb, Brian C. Baldwin, Diane E. Kelly, Steven L. Kelly, David J. Lowe
Publikováno v: The Journal of biological chemistry. 272(9)
Sterol 14alpha-demethylase (P45051) is the target for azole antifungal compounds, and resistance to these drugs and agrochemicals is of significant practical importance. We undertook site-directed mutagenesis of the Candida albicans P45051 heterologo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::728af1412b86cd97624474907efe8686
https://pubmed.ncbi.nlm.nih.gov/9038178
Zobrazit plný text záznamu
8
Mechanistic kinship between hydroxylation and desaturation reactions: acyl-carbon bond cleavage promoted by pig and human CYP17 (P-450(17)alpha; 17 alpha-hydroxylase-17,20-lyase)
Autor: Akbar Z. Shyadehi, J N Wright, M. E. Akhtar, Muhammad Akhtar, Peter Lee-Robichaud
Publikováno v: Biochemistry. 34(43)
Using homogeneous pig and recombinant human CYP17, the mechanism of the acyl-carbon bond fission involved in the direct cleavage of pregnenolone was studied. It was found that the formation of androsta-5,16-dien-3 beta-ol (5,16-diene) and androst-5-e
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0411f3d9e612867f24cfb2b2212be02e
https://pubmed.ncbi.nlm.nih.gov/7578007
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje