Zobrazeno 1 - 6 of 6 pro vyhledávání: '"Akash Raju"'
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Akademický článek
Inhibition of autophagy and MEK promotes ferroptosis in Lkb1-deficient Kras-driven lung tumors
Autor: Vrushank Bhatt, Taijin Lan, Wenping Wang, Jerry Kong, Eduardo Cararo Lopes, Jianming Wang, Khoosheh Khayati, Akash Raju, Michael Rangel, Enrique Lopez, Zhixian Sherrie Hu, Xuefei Luo, Xiaoyang Su, Jyoti Malhotra, Wenwei Hu, Sharon R. Pine, Eileen White, Jessie Yanxiang Guo
Publikováno v: Cell Death and Disease, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract LKB1 and KRAS are the third most frequent co-mutations detected in non-small cell lung cancer (NSCLC) and cause aggressive tumor growth. Unfortunately, treatment with RAS-RAF-MEK-ERK pathway inhibitors has minimal therapeutic efficacy in LKB
Externí odkaz: https://doaj.org/article/5290d1394aaa48838b42a4b8a39fdce8
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2
Abstract 272: Autophagy and MEK inhibition promotes ferroptosis in liver kinase B1 (Lkb1)-deficient Kras-driven lung tumors
Autor: Vrushank Bhatt, Taijin Lan, Wenping Wang, Jerry Kong, Eduardo Cararo Lopes, Khoosheh Khayati, Jianming Wang, Akash Raju, Michael Rangel, Enrique Lopez, Zhixian Sherrie Hu, Xuefei Luo, Xiaoyang Su, Jyoti Malhotra, Wenwei Hu, Sharon R. Pine, Eileen White, Jessie Yanxiang Guo
Publikováno v: Cancer Research. 83:272-272
Tumor suppressor Liver Kinase B1 (LKB1) activates 5’-adenosine monophosphate protein kinase (AMPK) and maintains energy homeostasis in response to energy crises. LKB1 and KRAS are the third most frequent co-mutations detected in non-small cell lung
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::da3d26320b0a8b3462e401c119fc0cd0
https://doi.org/10.1158/1538-7445.am2023-272
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4
Abstract 88: Autophagy inhibition sensitizes liver kinase b1 (LKB1)-deficient kras-driven lung tumors to MEK inhibitor trametinib
Autor: Vrushank Dharmesh Bhatt, Taijin Lan, Wenping Wang, Khoosheh Khayati, Eduardo Cararo-Lopes, Jianming Wang, Jerry Kong, Akash Raju, Xuefei Luo, Wenwei Hu, Xiaoyang Su, Eileen White, Jessie Yanxiang Guo
Publikováno v: Cancer Research. 81:88-88
Tumor suppressor Liver Kinase B1 (LKB1) activates 5'-adenosine monophosphate protein kinase (AMPK) and maintains energy homeostasis in response to energy crises. LKB1 and KRAS are the third most frequent co-mutations detected in non-small cell lung c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::62819d0552b48fda972ed6da553cea65
https://doi.org/10.1158/1538-7445.am2021-88
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5
Abstract 5710: Autophagy inhibition sensitizes Liver Kinase B1 (LKB1) - deficient Kras-driven lung tumors to MEK inhibitor Trametinib
Autor: Khoosheh Khayati, Jessie Yanxiang Guo, Jerry Kong, Akash Raju, Vrushank Bhatt, Xiaoyang Su, Zhixian Hu
Publikováno v: Cancer Research. 80:5710-5710
Tumor suppressor liver kinase B1 (LKB1) activates 5'-adenosine monophosphate protein kinase (AMPK) and plays an essential role in maintaining energy homeostasis. LKB1 mutations are the third most frequent mutation detected in non-small cell lung canc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::228cb3482751b574a6eb97cfeef409e9
https://doi.org/10.1158/1538-7445.am2020-5710
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