Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Akash K. Kaushik"'
Autor:
Pravat Kumar Parida, Mauricio Marquez-Palencia, Akash K. Kaushik, Kangsan Kim, Vidhya Nair, Jessica Sudderth, Hieu Vu, Lauren Zacharias, Ralph DeBerardinis, Srinivas Malladi
Publikováno v:
STAR Protocols, Vol 3, Iss 2, Pp 101345- (2022)
Summary: Analyzing the metabolic dependencies of tumor cells is vital for cancer diagnosis and treatment. Here, we describe a protocol for 13C-stable glucose and glutamine isotope tracing in mice HER2+ breast cancer brain metastatic lesions. We descr
Externí odkaz:
https://doaj.org/article/e0b5c74ee75b49fa8e475f282fe365d9
Autor:
Anindita Ravindran, Kimiko L. Krieger, Akash K. Kaushik, Hélène Hovington, Sadia Mehdi, Danthasinghe Waduge Badrajee Piyarathna, Vasanta Putluri, Paul Basil, Uttam Rasaily, Franklin Gu, Truong Dang, Jong Min Choi, Rajni Sonavane, Sung Yun Jung, Lisha Wang, Rohit Mehra, Nancy L. Weigel, Nagireddy Putluri, David R. Rowley, Ganesh S. Palapattu, Chantal Guillemette, Louis Lacombe, Éric Lévesque, Arun Sreekumar
Publikováno v:
Cells, Vol 11, Iss 15, p 2329 (2022)
Prostate cancer (PCa) is the second most diagnosed cancer in the United States and is associated with metabolic reprogramming and significant disparities in clinical outcomes among African American (AA) men. While the cause is likely multi-factorial,
Externí odkaz:
https://doaj.org/article/21fa31e76e474fb6b719fbe7d3615cfd
Autor:
Akash K. Kaushik, Ali Shojaie, Katrin Panzitt, Rajni Sonavane, Harene Venghatakrishnan, Mohan Manikkam, Alexander Zaslavsky, Vasanta Putluri, Vihas T. Vasu, Yiqing Zhang, Ayesha S. Khan, Stacy Lloyd, Adam T. Szafran, Subhamoy Dasgupta, David A. Bader, Fabio Stossi, Hangwen Li, Susmita Samanta, Xuhong Cao, Efrosini Tsouko, Shixia Huang, Daniel E. Frigo, Lawrence Chan, Dean P. Edwards, Benny A. Kaipparettu, Nicholas Mitsiades, Nancy L. Weigel, Michael Mancini, Sean E. McGuire, Rohit Mehra, Michael M. Ittmann, Arul M. Chinnaiyan, Nagireddy Putluri, Ganesh S. Palapattu, George Michailidis, Arun Sreekumar
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
The molecular alterations driving anti-androgen resistance in prostate cancer are unclear. Here, the authors show, using a network-based approach, that inhibition of the hexosamine biosynthetic pathway is necessary to develop resistance and that incr
Externí odkaz:
https://doaj.org/article/928bd0a4d45444ac89e49f796339b9e4
Autor:
Akash K. Kaushik, Amy Tarangelo, Lindsey K. Boroughs, Mukundan Ragavan, Yuanyuan Zhang, Cheng-Yang Wu, Xiangyi Li, Kristen Ahumada, Jui-Chung Chiang, Vanina T. Tcheuyap, Faeze Saatchi, Quyen N. Do, Cissy Yong, Tracy Rosales, Christina Stevens, Aparna D. Rao, Brandon Faubert, Panayotis Pachnis, Lauren G. Zacharias, Hieu Vu, Feng Cai, Thomas P. Mathews, Giannicola Genovese, Barbara S. Slusher, Payal Kapur, Xiankai Sun, Matthew Merritt, James Brugarolas, Ralph J. DeBerardinis
Publikováno v:
Science advances. 8(50)
Targeting metabolic vulnerabilities has been proposed as a therapeutic strategy in renal cell carcinoma (RCC). Here, we analyzed the metabolism of patient-derived xenografts (tumorgrafts) from diverse subtypes of RCC. Tumorgrafts from VHL -mutant cle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc0a4bd0299ff1de7f2a294b731843bb
https://pubmed.ncbi.nlm.nih.gov/36525494
https://pubmed.ncbi.nlm.nih.gov/36525494
Autor:
Panayotis Pachnis, Zheng Wu, Brandon Faubert, Alpaslan Tasdogan, Wen Gu, Spencer Shelton, Ashley Solmonson, Aparna D. Rao, Akash K. Kaushik, Thomas J. Rogers, Jessalyn M. Ubellacker, Collette A. LaVigne, Chendong Yang, Bookyung Ko, Vijayashree Ramesh, Jessica Sudderth, Lauren G. Zacharias, Misty S. Martin-Sandoval, Duyen Do, Thomas P. Mathews, Zhiyu Zhao, Prashant Mishra, Sean J. Morrison, Ralph J. DeBerardinis
Publikováno v:
Science advances. 8(35)
In mice and humans with cancer, intravenous 13 C-glucose infusion results in 13 C labeling of tumor tricarboxylic acid (TCA) cycle intermediates, indicating that pyruvate oxidation in the TCA cycle occurs in tumors. The TCA cycle is usually coupled t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0af7fc1ab75f656b5635de09b67667ac
https://pubmed.ncbi.nlm.nih.gov/36044570
https://pubmed.ncbi.nlm.nih.gov/36044570
Autor:
Qing Zhang, Juan Liu, Jason W. Locasale, Kevin R. Mott, Ralph J. DeBerardinis, Charles M. Perou, Hieu Sy Vu, Akash K. Kaushik, Chengheng Liao, Cheng Fan, Cherise Ryan Glodowski, Samuel K. McBrayer
Metabolic dysregulation, although a prominent feature in breast cancer, remains undercharacterized in patient tumors. By performing untargeted metabolomics analyses on triple-negative breast cancer (TNBC) and Estrogen Receptor (ER) positive patient b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef0ef6efb49f5f33cbaf9c2bfa727383
https://doi.org/10.21203/rs.3.rs-117384/v2
https://doi.org/10.21203/rs.3.rs-117384/v2
Autor:
Jiyeon Kim, Feng Cai, Bookyung Ko, Chendong Yang, Hyun Min Lee, Nefertiti Muhammad, Kailong Li, Mohamed Haloul, Wen Gu, Brandon Faubert, Akash K. Kaushik, Ling Cai, Sahba Kasiri, Ummay Marriam, Kien Nham, Luc Girard, Hui Wang, Xiankai Sun, James Kim, John D. Minna, Keziban Unsal-Kacmaz, Ralph J. DeBerardinis
In non–small cell lung cancer (NSCLC), concurrent mutations in the oncogeneKRASand the tumor suppressorSTK11encoding the kinase LKB1 result in aggressive tumors prone to metastasis but with liabilities arising from reprogrammed metabolism. We previ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c72bce83370ee6f88613297452b1b970
Autor:
Hollis Notgrass, Hua Zhong, Andrea Pavia-Jimenez, Vanina Tcheuyap, Ming Gao, Vitaly Margulis, Roy Elias, Ivan Pedrosa, Aditi Mulgaonkar, Oscar Reig Torras, Nirmish Singla, Christina Stevens, Zora Modrusan, Layton Woolford, Brandi L. Cantarel, Xiankai Sun, Marianna Dakanali, Ralph J. DeBerardinis, Somasekar Seshagiri, Kavitha Priya Kettimuthu, Allison Joyce, Jeffrey A. Cadeddu, Noelle S. Williams, Akash K. Kaushik, Orhan K. Öz, Payal Kapur, Alana Christie, Lindsey K. Boroughs, James Brugarolas
Publikováno v:
Cell reports
SUMMARY Renal cell carcinoma (RCC) encompasses a heterogenous group of tumors, but representative preclinical models are lacking. We previously showed that patient-derived tumorgraft (TG) models recapitulate the biology and treatment responsiveness.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d0aed6967cf60b9ef3fc21badc5d602
https://doi.org/10.1016/j.celrep.2021.110055
https://doi.org/10.1016/j.celrep.2021.110055
Autor:
Efrosini Tsouko, Ali Shojaie, Ayesha S. Khan, David A. Bader, Harene Venghatakrishnan, Dean P. Edwards, Ganesh S. Palapattu, Daniel E. Frigo, Vihas T. Vasu, Sean E. McGuire, Rajni Sonavane, Lawrence Chan, Yiqing Zhang, Alexander Zaslavsky, Fabio Stossi, Nagireddy Putluri, Katrin Panzitt, Mohan Manikkam, Nancy L. Weigel, Akash K. Kaushik, Michael Ittmann, Arun Sreekumar, Adam T. Szafran, Nicholas Mitsiades, Stacy M. Lloyd, Xuhong Cao, Benny Abraham Kaipparettu, Arul M. Chinnaiyan, Michael A. Mancini, Subhamoy Dasgupta, Susmita Samanta, Vasanta Putluri, Shixia Huang, George Michailidis, Hangwen Li, Rohit Mehra
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Nature Communications
Nature Communications
The precise molecular alterations driving castration-resistant prostate cancer (CRPC) are not clearly understood. Using a novel network-based integrative approach, here, we show distinct alterations in the hexosamine biosynthetic pathway (HBP) to be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d1b364a8583c64ef551af7dbe0a5e8a
https://doaj.org/article/928bd0a4d45444ac89e49f796339b9e4
https://doaj.org/article/928bd0a4d45444ac89e49f796339b9e4
Autor:
Layton Woolford, Ralph J. DeBerardinis, James Brugarolas, Mukundan Ragavan, Cissy Yong, Christina Stevens, Matthew E. Merritt, Hieu Sy Vu, Panayotis Pachnis, Brandon Faubert, Aparna Rao, Akash K. Kaushik, Lauren G. Zacharias
Publikováno v:
Cancer Research. 80:245-245
Renal cell carcinoma (RCC) is one of the top 10 diagnosed cancers in the United States, and it accounts for about 64,000 deaths every year. In recent years, combinations of surgery and targeted therapies have significantly improved patient outcomes;
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c81a421cd6a3f3f717843bf06e58ef31
https://doi.org/10.1158/1538-7445.am2020-245
https://doi.org/10.1158/1538-7445.am2020-245